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:100730,,(LDL2C)(AS)(CHD),LDL2CCHD(NCEP)LDL2C,LDL2CLDLLDL,(d)1.0061.063kg/LLDL(CE)(PL)(Pro)(TG)38%22%21%11%8%LDL3,LDLLDL(26nm),(1.041.06kg/L),LDL(small,denseLDL),BLDL;LDL(27nm),(1.021.03kg/L),LDL(large,buoyantLDL),ALDL;LDL[1]LDLCHD,LDL,LDLAS,HDLTGLDL2CLDL2CapoB,LDL,LDL,11:(CDC)LDL2C(Beta2quantification,2),NCEP[2,3]HDL2CVLDL(d1.006kg/L),d1.006kg/L(Chol),HDL2C:[LDL2C]=[d1.006kg/LChol]-[HDL2C]LDL2C,(a)[Lp(a)](IDL),LDL2C2,21Friedewald:LDL2C,VLDL(VLDL2C/TG=0.2,mg/dl),:(1)LDL2C=TC-HDL2C-TG/2.2(mmol/L)(2)LDL2C=TC-HDL2C-TG/5(mg/dl)LDL2CTCTGHDL2CFriedewaldLDL2C9.5%,TCTGHDL2C[2],,Friedewald:(1)CM(2)TG4.52mmol/L(400mg/dl)(3)[(HLP)][3]Planella[4]apoBTCTGLDL2C,TG,Planella:LDL2C=0.41TC-0.32TG+1.70apoB-0.27(TCTGmmol/L,apoBg/L)LDL2C1.45%,Friedewald(2.97%),2,296.8%,Friede2wald(93.0%)TG,Friedewald823ChinJMedLabSci,November1998,Vol21,No.6©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.apoB,31:2(PVS)LDL,CholHDL2CVLDL2C,TCCholLDL2CPVS,,pH38PVSChol,PVSPVSLDL2C[5]IDLLp(a)Lp(a)LDL,Lp(a)30%,Lp(a),LDL2CLp(a)0.3(mg/L)LDL2C,LDL2CLp(a),Lp(a),LDL2C[6]TG(4.52mmol/L),LDLReferenceDiagnosticsLDL2C,37C10,,LDLTCLDL2CLDL2C[7],,(CV2.5%),Friedewald(r=0.942),2TG,4.(ImmunoseparationMethod):Leary[8]1993,GenzymeDiagnos2ticsLDL2CSigma200lPEGapoEapoA30l(200nm),510,HDL(apoA/E)IDL(apoE)VLDL(apoE)CM(apoA/E);120012000g(2200g)5;,;,LDL2C[2,810](CV3%),,LDL2C2,TG,,,,LDL2C25%,50%75%Levinson[11],TG4.52mmol/LTG1.702.83mmol/L,FriedewaldLDL2CTG4.52mmol/LLDL2C,HLPLDL2C51(Homogeneousassay):LDL2C,,,,(1)[1214]:,:11HDLCMVLDL,Chol,,H2O2,LDL2(2DSBmT),LDLChol,Trinder,Chol,LDL2C[12,13](Daiichi)DA26101GenzymeDiagnosticsN2genousTMLDL2C(3l),(CV2.5%),4.52mmol/L,90%110%,2(r=0.9580.992),VitCTCTG14.7mmol/L,20.5mmol/L,LDL2C12(DS500)MgCl2EMSEMOPS,2CHERCHOD42AAPOE2923199811216©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.POPMOPS2DSMg2+,CMVLDL2(POE2POP)HDLLDL2C[14]TG0.322.6mmol/L2,15.5mmol/L,0.005mmol/L,97%105%,0.6812.9mmol/L,LDL2C10%7.8%,(2)[15]:BoehringerMannheimPAMPSLDL1HDLCMVLDL(TG)2[(PAMPS)],Mg2+,LDLPAMPSLDL2,LDL2C2(r=0.97),CV0.9%5.7%(LDL2C1.258.40mmol/L),1.310.4mmol/L,CV4.7%,,TG4.52mmol/L,31Technicon(3)PEG:PEG(CHER/PEG,CHOD/PEG)1LDL,HDLVLDLCM,Chol,H2O22,LDL2C,LDL2C(Kyowa)61:,,()HDL,Lp(a)VLDLLDL,LDL,TC,LDL2C[16]HelenaREPLDL2C,VLDL2CHDL2CLp(a)2C,LDL2C,Lp(a),TG4.52mmol/LLDL2C10.4mmol/L,0.065mmol/LLDL2CCV1.3%2.7%,CV3.7%,2(r=0.998),6.0%LDL2C13.3%,NCEP12.0%LDL2CLDL2C,LDL2CLDL2C,LDL2C11:LDL2C(CVb)(CVa),LDL2CCVb6%11%(8.2%),CVa3%7%(4%)NCEPLDL2C,12%;CV4%,4%(2)21:LDL2C,LDL2CLDL2C1,NCEPCDC2,2CDC(NISTSRM1951a,CAPRM026)CDC,(CRMLN)(LSP)CDC,,(LDL),,CDCLDL2C,LDL2C(1.6%),LDL2C,,LDL2C[17],,,LDL2C033ChinJMedLabSci,November1998,Vol21,No.6©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,LDL2CLDL2C,,;LDL2C31:NCEPLDL2C,LDL2C,LDL2C,NCEPCDC2,Friedewald(PVS)LDL2C,,,TC,LDL2C,LDL2C,:1HokansonJE,AustinMA,BrunzellJD.Measurementandclinicalsignificanceoflow2densitylipoproteinsubclasses.In:RifaiN,War2nickGR,DominiczakMH,eds.Handbookoflipoproteintesting.WashingtonDC:AACCPress,1997.2672282.2BachorikPS.Measurementoflow2densitylipoproteincholesterol.In:RifaiN,WarnickGR,DominiczakMH,eds.Handbookoflipoproteintesting.WashingtonDC:AACCPress,1997.1452160.3BachorikPS,RossJW.NationalCholesterolEducationProgramrecommendationsformeasurementoflow2densitylipoproteincholes2terol:executivesummary.ClinChem,1995,41:141421420.4PlanellaT,CortesM,Martinez2BruC,etal.CalculationofLDL2cholesterolbyusingapolipoproteinBforclassificationofnonchy2lomicronemicdyslipemia.ClinChem,1997,43:8082815.51()1,1995,18:381238216,,,1(a)1,1995,23:421242317LawlorJ,PelczarD,SaneR.PerformancecharacteristicsoftheLi2pidirectmagneticLDLcholesterolreagent.ClinChem,1997,43:2622270.8LearyET,TjerslandG,WarnickGR.EvaluationoftheGenzymeimmunoseparationreagentfordirectquantitationofLDLcholes2terol.ClinChem,1993,39:112421131.9MaitraA,HiranySV,JialalI.Comparisonoftwoassaysformea2suringLDLcholesterol.ClinChem,1997,43:104021047.10PisaniT,GebskiCP,LearyET,etal.Accuratedirectdetermina2tionoflow2densitylipoproteincholesterolusinganimmunosepara2tionreagentandenzymaticcholesterolassay.ArchPatholLabMed,1995,119:112721135.11LevinsonSS,MaciejkoJJ.DirectmeasurementofLDLcholesterol.ClinChem,1996,42:7802781.12NakomuraM,TaniguchiY,YamamotoM,etal.HomogeneousassayofserumLDL2cholesterolonanautomaticanalyzer.ClinChem,1997,43:2602261.13HalloranP,PisaniT,LongS.AhomogeneousassayforthedirectmeasurementofLDL2cholesterolinserum.ClinChem,1997,43:2542258.14SugiuchiH,IrieT,UjiY,etal.Homogeneousassayformeasuringlow2densitylipoproteicholesterolinserumwithtrilockcopolymerand2cyclodextrinsulfate.ClinChem,1998,44:5222531.15FujitaS,MoriwakiK,KatayamaY,etal.Evaluationofahomoge2neousassaymethodforserumLDL2cholesterol.ClinChem,1997,43:2632267.16WarnickGR,LearyET,GoetschJ.ElectrophoreticquantitationofLDL2cholesterolusingtheHelenaREP.ClinChem,1993,39:112221126.17,11,1998,21:132151(:1997212215:1998206209)(:)19799,,,,,1664,7100,28100,18261:050017,361:(0311)604412126984;:(0311)6059153;http:©1995-2005Tsing