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12PMMA(polymethylmethacrylate)ArtecollAffirmIPL(intensivepulselight)ELOSERF(radiofrequency)5PMMA/ArtecollArtecollPMMAArtecollArtecoll.0412078Artecoll://://:Nowadays,moreandmoredermalfillersareusedinestheticalfieldsuchaswrinklereductionandcontourrefining.Amongthem,Artecoll,whichisfrequentlyusedinourdepartment,isoneofthemosttypicalpermanentinjectabledermalfillers.There’sanurgentdemmandforustoinvestigatetheefficacyandsafetyretrospectively.Besidesdermalfillers,therearenumerousmethodstodealwiththeagingprocess,includingthenon-invasivemethodsthathadbeenwidelyusedsuchasmonopolarradiofrequency,intensivepulselightetc.Inmanycases,patientswhohavepreviouslybeeninjectedwithdermalfillerwillhavethechancestoundergothosenon-invasivetreatment.Nevertheless,thecomplicationofArtecolliscloselyrelatedtothesmoothsurfaceofPMMAmicrospheres.Multipuletreatmentoffillerimplantationandthose(polymethylmethacrylate/PMMA)asaninjectabledermalfiller.Method:1.AretrospectivereviewoftheliteratureandevaluationofourclinicalexperiencewithArtecollimplantationwereperformed.TheinformationofpatientswhounderwentArtecollimplantationbetweenDecember,2004,andAugust,2007werereviewedviacompletionofthesurvey.Variablesincludingclinicaleffect,complications,etc.werestatisticallyanalysedthen.2.1.InvitroUsingAffirmdirectlyonArtecoll,thenobservetheintegrityandthesurfacetoseeifthereisanychangethroughmicroscope.2.2.Usingpigandguineapigastheshort-termandlong-termmodelsrespectivelyforArtecoll.Injectthedermalfillerfirstandthenlasertreatmentsaredone.Observetheskinsamplethroughlightmicroscope,scanningelectronicmicroscopeandtransmissionelectronicmicroscopetoseewhetherthereareanystructuralchanges,theinfiltrationofinflammatory:1.Allpatientshadapositiveeffectofdifferentdegreeimmediately;Theeffectiverateswere:100%.Thecomprehensivelyscorewas3.78(1week),2.91(3months),2.81(12months),2.79(24months).Andtheireffectiverateswere:99.5%,92.2%,91.4%,90.6%.Noseverecomplicationssuchasgranuloma,allergicreaction,orinfectionwerefoundaftertheinjection.2.Throughthemicroscopicobservationofinvitroexperimentandtheanimalpatterns,nodistortionorruptureofthemicrospherewerefoundafterthelasertreatment.NounevensurfacewasfoundinthePMMAmicrosphereeither.Themicroshperewassurroundedbytheinflammatorycells.Theinfiltrationwasmildtointermediatewithfewforeignbodygiantcellsevenafterseveraltreatmentsoflaser.Therewasnomacrophageseen.Butthecollagenregenerationwasdistinguishableafterthelasertreatment.Noobviousstructuralchangewasfoundeventually.Conclusion:Artecollisasafeandeffectivepermanentinjectabledermalfillerforwrinklereductionandcontourrefining.KEYWORDS:polymethylmethacrylate,artecoll,injectabledermalfiller,laser,radiofrequency,intensivepulselight[1][2][3][4]semipermanent[5][6][7]12345[8]RF(IPL)[1011][12][11][13]ArtecollPMMA3.50.3[8]FDAArtecollPMMA30-40m27[9]1997[14]GottfriedLemperleArtecollPMMA[9]Morhenn[15][16]PMMA[7]ArtecollPMMAArtecollArtecollArtecollArtecoll://:13612244GlobalAestheticImprovementScale[10]18.GlobalAestheticImprovementScale4321075%50%,75%25%,50%0%,25%=4+3+2/100%1.1.4SPSS10.0PP0.051.1.5tunneltechnique5191.21.2.146331224()P0.051P0.05312241χ2=620.38P0.0012416664.15%SPSS10.01-4.1312243923421098175626413712111291086858202282728000004634183603142973.830.433.780.502.910.932.820.922.790.93%10099.592.291.490.61.2.21-7214.527101111651-3A201.2.213.4.6222.2.12.1.125kgSCXK()2007-0013350g()10SCXK()2004-20052.1.2HafodBioscienceB.V.Artecoll20800.3%0.52.1.3EELOSPolarisE900nmIPLLumenisOneAffirmCynosurePHILIP()CM—120QUANTA-2002.1.4ArtecollAffirm,PMMA2.1.52.1.5.1ArtecollArtecoll231271413HEPMMAArtecoll2.1.5.2IPLEAffirmIPL:640nm25J/cm2,3E30J/cm2RF100J/cm3Affirm5.0J/cm2IPLEAffirm11.5Affirm211.52IPL+EAffirm2.1.5.3ArtecollIPL+EIPL+EAffirmAffirm21271411.5ArtecollIPL+EAffirm2.1.5.4ArtecollIPL+EAffirm1ArtecollIPL+EAffirm3PMMA2.1.62%PBS24PBS104241%PBS24PBS10430%50%70%1070%3%480%95%100%100%1010618112618216183766048LKBV.:.2.1.72%PBS24PBS1041%PBS24PBS10430%50%70%80%95%100%100%1010HITACHIHCP2BAL-TEC2.1.8180%90%95%100%20.10.2cm2540456065153051021153100