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(,643000):(VPA)(SE):60SE30,10mg,(1.52.0)g/(kgmin);(1015)mg/kg,35min,(0.51)mg/(kgh),:83.3%,66.7%,(P0.05)(29.0110.84)s[(34.9310.54)s](P0.05):VPA,,;R742.1A100420188(2009)0820782202doi:10.3969/j.issn.100420188.2009.08.008SafetyandtherapeuticeffectsofsodiumvalproateonepilepticstateYANGJian2mingDepartmentofNeurology,FourthPeople’sHospitalofZigongCity,Zigong,Sichuan,643000,China.AbstractObjective:Toassesseffectsandsafetyofrapidintravenouslyguttaeofsodiumvalproateonepilepticstate(SE).Methods:60casesofSEpatientswererandomlydividedintotreatmentgroupandcontrolgroup(n=30).Incontrolgroup,diazepamwasfirstlygivenbyintravenousinjectionat10mg,andthenitwasgivencontinuouslybyintravenousdripat(1.52.0)g/(kgmin).Intreatmentgroup,intravenousinjectionofsodiumvalproatewasfirstlyadministeredat(1015)mg/kgwithin35minutes,andthenitwasadministeredcontinuouslybyintravenouslyguttaeat(0.51.0)mg/(kgh)whichwasadjustedaccordingtothepatients’state.Results:Theoverallefficiencyoftreatmentgroupwas83.3%andwassignificantlyhigherthanthatofcontrolgroup(66.7%)(P0.05).Thetotalcontroltimeoftreatmentgroupwas(29.0110.84)secondsandwassignificantlyshorterthanthatofcontrolgroup[(34.9310.54)seconds](P0.05).Conclusion:RapidintravenouslyguttaeofsodiumvalproatearesafeandhasstrongandquickefficacyonSE.Keywords:sodiumvalproate;epilepticstate(SE),30min1SE2.5%14.0%38.0%,22.0%,;,;;11.12004320085SE60,,,3017,13,1872,46;16,14,1576,49(P0.05)SE230h,14.3h,15,242,15;232,7SE428h,13.3h,14,645,12,252,5SE(P0.05)1.2:5,3,1,2,3,6,10;:3,4,2,2,4,2,2,11(P0.05)1.3,10mg,(1.52.0)g/(kgmin),,(0.10.5)g/(kgmin),,3g/(kgmin)(1015)mg/kg,35min,(0.51)mg/(kgh)48h,28720091981.4:,;:,,;:,21.5,PEMS,P0.0522.183.3%,66.7%,(P0.05);24h22,19,[(29.0110.84)s];[(34.9310.54)s];(P0.05);(P0.05),121n(min)(s)30255329.0110.845302022634.9310.5410:,P0.052()n(%)3025583.330201066.7:,P0.052.2,350,515,6,3,2;,4,,1,1,3,22,2,-,75mg/L3,,83.3%1996FDAVPASE,20mg/min4VPA,VPASE3,55,VPA,6mg/(kgmin)46,45mg/kg6,66%100%5,7SE5min,[(50100)mg/L],,,100%,(50100)mg/L,816h,,,,,,,VPA,,,,30VPA,(56)mg/(kgmin),1VPA,,,,3,,,,,14h,30h,,,,,,,,1.[M].7.:,2004:2442245.2.[J].,2000,8(18):4351.3WHELESSJW,VENKATARAMANV.Safetyofhighintravenousvalproateloadinginepilepsypatients[J].JEpilepsy,1998,11:3192324.4RAMSAYRE,CANTRELLD,COLLINSSD,etal.SafetyandtoleranceofrapidlyinfusedDepacon:arandomizedtrialinsubjectswithepilepsy[J].EpilepsyRes,2003,52:1892201.5HODGESBM,MAZURJE.Intravenousinstatusepilepticus[J].AnnPharmacother,2001,35:146521470.6VENKATARAMANV,WHELESSJW.Safetyofrapidintravenousinfusionofvalprateloadingdosesinepilepsypatients[J].EpilepsyRes,1999,35:1472153.7SINHAS,NARITOKUDK.Intravenousvalproateiswelltoleratedinunstablepatientswithstatusepilepticus[J].Neurology,2000,55:7222724.:20092072023872009198