新型qtrap～tm四极杆-线性离子阱串联质谱仪

33037167133:E-mail:[e-mail];Tel:[phone];Fax:[phone]QTRAPTM2333(100050)QTRAPTM-;-(QTRAP),20(),HPLCLC-MS,(MS/MS),MS/MS,(QqQ)MS/MS,(PROS)()(PRES)(NLS)MS/MS,,,MS23D(MSn),,,(1/3)(QqTOF)MS/MS,,(CID),;,PRESNLS(MRM),,,,,,AppliedBiosystems/MDSSciex()QTRAPTM-LC-MS/MS2002(QpQ)(API2000,API4000)(Q3)(LIT),(ESI)(APCI)HPLCQ3;,MS/MS,,,MS/MS,QTRAPTM,,IDA(InformationDependantAc2quistion),QTRAPTM1QTRAPTMRF/DC(/)(Q1q2Q3),(Q3)(LIT),Hager1,OrificeSkim2mer,Q0Q0,,Q1(MS1),,;q2,,(N2)q2;Q3(LIT)LIT,,Z-,,9,,3D,,,,QTRAPTM(1)1QTRAPTM-,,(PROS)(PRES)(NLS)(MRMSRM);(MS3),,(EMS)(EPI)Q3(ERMS)(TDF);(IDA)3D,(1/3),QTRAP,1QTRAPTM1QTRAPTMQ1q2Q3Q1Q2/MS3/////////HagerQTRAPTM2QTRAPQ3RF/DC(),MS/MS,3D(Q0)RF,,,20QTRAP,,MRM,3D,(LIT)1,,QTRAP3,,,,,,QTRAPLC-MS/MS4,,,Q3,,MS3QTRAP,,,QTRAPLC-MS/MS2QTRAPTM-LC-MS/MS,,012002,211QTRAPLC-MS/MSMS/MSIDA,,Hopfgartner5,(ESI),IDA,,QTRAP,QTRAP,MS/MS,3DMS3,NLSPRES(EPI),pg,,IDA,EPI(SRM)QTRAPLiuDQQTRAPLC-MS/MSgemfibrozilpropranolol6IDA,MSNLS,(MS2)MS3,gemfibrozil5,NLSPRESMRM,3D,propra2nolol,MRMEPI,LC2MS/MSGC2MSHPLC2DAD(GUS)Marquet7QTRAPLC2MS/MS,IDAGUS,EMS,,Q3;EPI,LC2MS/MS8,QTRAPLC-MS,,,IDA,011mg/L,QTRAPLC2MS/MS,GUS8,20039QTRAPLC2MS/MS,(ABP),MRM,r=0.9985,6125200ngmL216125ngmL21,API3000(210ngmL21),IDAABPEMSNLSPRES,EPIPROS,212,QTRAP,(LIT),D2OCD3OD,H/D9H/D,,H/DQTRAPTMLC-MS/MS,,12()10001001fmol/L,123D,Hager10,HPLC,,,,,11MS/MSSandra113D,(MS2),3D,,MS3LC2MS/MSIDA,,QTRAP213,AutoSpecUlti2ma2Tof(,2Tof),LCQ3D(),1215,MS/MSLC2MSn,()QTRAP(),QTRAPMS/MS,EMSEPIERMSIDA,3D,MS/MS,QTRAPMS/MS(PROS)MS/MS,EPI3DMS2,,,QTRAPMS/MS,,,D(2),D,,RDA,ESI2MSn,,[M2CH3]+[M2CH4]+,QTRAPMS/MS,(16Da),[M2CH4]+[M2CH3]+[M2CH4]+(2),,;,[M2CH32H]+2,QTRAPLC2MS/MS,,()1HagerJW.Anewlineariontrapmassspectrometer.RapidCommun.MassSpectrom.,2002,16:5125262HagerJW,YvesLeBlancJC.ProductionscanningusingaQ-q-Qlineariontrap(QTRAPTM)massspectrometer.RapidCommun.MassSpectrom.,2003,17:105610643HagerJW.Productionspectralsimplificationusingtime-de2layedfragmentioncapturewithtandemlineariontraps.RapidCommun.MassSpectrom.,2003,17:138913984HagerJW,YvesLeBlancJC.High-performanceliquidchro2matography-tandemmassspectrometrywithanewquadrupole/lineariontrapinstrument.J.Chromatogr.A,2003,1020:395HopfgartnerG,HusserCandZellM.Rapidscreeningandchar2acterizationofdrugmetabolitesusinganewquadrupole-lineariontrapmassspectrometerl.J.MassSpectrom.,2003,38:1381506XiaYQ,MillerJD,BakhtiarR,FranklinRB,LiuDQ.Useofaquadrupolelineariontrapmassspectrometerinmetaboliteiden2tificationandbioanalysis.RapidCommun.MassS0ectrom.,2003,17:113711457Marquetp,Saint-MarcouxF,GambleTN,LeblancJC.Compar2isonofapreliminaryprocedureforthegeneralunknownscreen2ingofdrugsandtoxiccompoundsusingaquadrupole-linearion-trapmassspectrometerwithaliquidchromatography-massspectrometryreferencetechnique.J.Chromatogr.B2003,789(1):9188Jin-pingQiao,ZeperAbliz3,Feng-mingChu,Pei-lingHou,Li-yanZhao,MinXia,YanChangandZong-ruGuo.Microdialysiscombinedwithliquidchromatography-tandemmassspectrometryforthedeterminationof6-aminobutylph2thalideanditsmainmetaboliteinthebrainofawakefreely-21movingrats.J.Chromatogr.b.,2004,805:93999MaoD,DingCF,DouglasDJ.Hydrogen/deuteriumexchangeofmyoglobinionsinalinearquadrupoleiontrap.RapidCommun.MassSpectrom.,2002,16:1941194510YvesLeBlancJC,HanerJW,PatriciaIlisiuAM,HunterC,ZhongF,ChuIvan.Uniquescanningcapabilitiesofanewhy2bridlineariontrapmassspectrometer(QTRAP)usedforhighsensitivityproteomicsapplications.Proteomics.2003,3:85986911SandraK,DevreeseB,andBeeumenJV.TheQ-TrapMassSpectrometer,aNovelToolintheStudyofProteinGlycosyla2tion.J.Am.Soc.MassSpectrom.,2004,15:41342312FengLiang,Li-junLi,ZeperAbliz3,Yun-chongYang,Jian-gongShi.Structuralcharacterizationofsteroidalsapoinsbyelectrosprayionizationandfast-atombombardmenttandemmassspectrometry.RapidCommun.MassSpectrom.2002,16(12):1168117313YunXiang,ZeperAbliz3,Li-junLi,Xue-shiHuangandShi-shanYu.SstudyonStructuralCharacteristicFeaturesofPhenanthriondolizidineAlkaloidsbyFastAtomBombardmentwithTandemMassSpectrometry.RapidCommun.MassSpec2trom.,2002,16(17):1668167414LijieCui,-ZeperAbliz3,MinXia,LiyanZhao,SongGao,WenyiHe,YunXiang,Fengliang,andShishanYu.on-lineIdentificationofPhenanthroindolizidineAlkaloidsinaCrudeExtractfronTylophoraatrofolliculatabyLiquidChromatographyCombinedwithTandemMassSpectrometry.RapidCommun.MassSpectrom.2004,18:18419015YongzhenLiu,FengLiang,LijieCui,MinXia,LiyanZhao,YongchunYang,JiangongShi,andZeperAbliz3.Multi-stageMassSpectrometryofFurostanolSaponinsCombinedwithElectroaprayIonizationinPositiveandNegativeIonModes.RapidCommun.MassSpectrom.2004,18:235238Principleandapplicationsofanewquadrupole-lineariontrapmassspectrometer(QTRAPTM)ZeperAbliz3LiBinAblajanKeyumQiaoJingping(InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050)AbstractPrincipleandcharacteristicsofanewquadrupole-lineariontrapmassspectrometer(QTRAPTM)werere2viewed,anditsapplicationsindifferentfields,suchasscreeningandandalyzingofdrugmetabolites,peptideandproteinsequenceanalysis,andstructuralcharacterizationofnaturalproducts,werealsodescribed.K