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CommonLC/MSDContaminantsLastupdated:12/6/00MassIonizationModeCompound(s)Source(s)Remedy102ESIPosTriethylamine(TEA)CommonLCbuffer,verypersistent.Tubing,column,etc.PassivateLCwith5-10%aceticacidinmobilephase.Note:IfTEAisusedregularly,itisbettertohavePEEKtubing&columnsdedicatedforTEAuse.113ESINegTrifluoroaceticacid(TFA)CommonLCbufferusedinESIPosmode.WillseeacetateanionasabackgroundcontaminateinESINegmode.RinseLCsystem.IfneedtocontinuetouseTFAasbuffer,don’tscandownto113.114ESIPos??PlasticN2gastubing.UsetheteflonN2gastubingsuppliedwiththesystem.116ESIPosDetergentCDSbottles.RinseCDSbottleswithsolventbeforeaddingcalibrant149ESIPosAPCIPosRedBloomAlgaeWaterpurificationsystem;watersolventbottleRunwaterpurificationsystemfor30minutesbeforetakingwater;boilwater;bakesolventbottleinmufflefurnaceat400C.150,392APCIPosESIPosPhthalatesPlastics.Rinseplasticwarewithisopropylalcohol.Minimizeuseoflowdensitypolypropyleneplasticware.UseNalgeneorteflonplasticware.256,284ESIPos??Altechnylonfilters.Don’tusenylonfilterstofiltersolvents.311,352,640ESIPos??ColumnbleedFromnon-AgilentODcolumnsunderacidicconditions.331ESIPosEthylenepropyleneSealsinCDSvalves.Youshouldonlyseethiscontaminateionduringtuning.ReplacecalibrantinCDSbottleswithacetonitrilesolventandthenselectFlushCalibrantSystemfromInstrumentmenuinMSDTuneviewtoflushthecalibrantsystemovernight(min.8hours).341,360,689,699ESIPos??Binarypump(unknowncontaminant)Pumpwasreplacedtofixproblem453,472ESIPos??Binarypump.(unknowncontaminant)Pumpwasreplacedtofixproblem431,481,531,581,631,681ESIPosFluorinatedpolymerNewstylepumpseals(p/n5063-6589)+usingACN/waterasmobilephase.SeeMSNews#114.Ifpossible,switchtoMeOH/waterorIPA/waterasmobilephase,orreplacepumpsealswithyellowpolypropyleneseals(p/n0905-1420)122,123.9,132,134,144.9,146.9,258,815ESIPos??WaterReplacefiltersonMilliQsystem.MayalsobeleechingfromtubinginMilliQsystem.Apparently,high-endsystemusescleaner(teflon)tubing.536,610APCIPos??BrokeninsulatorsinAPCIVaporizerTrytobakevaporizerat500Covernight.Ifthatdoesn’thelp,replacevaporizer.