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©2002-2010EditorialDepartmentofChineseJournalofRespiratoryandCriticalCareMedicine.Allrightsreserved.㚎䱤⧗㦠⮙ⱘ䆞ᮁ⊏⭫ಙܟ᳞ࠚੜ؏ӪӖ༰ؘ೫ܟՊྤၝ܋ࢳ(౨ں200040)(PC)HIV,PC5%10%HIV,PC:Crohns15%PC,PC[1],[2]PC,50%,378,,,(),,,20%,4:A(vargrubii,)D(varneoformans,)BCADBC(vargattii,),,,[3]A[4]:,[5]1.:,,,,,,,2.:,,,PC,,PC,,(ARF),Bernicker[6]42HIV,18PC,12%(5/18)ARF1.:PC,:(1):,X(2):,PancoastsHorners[7,8](3):,(ARF),AIDS,(PCP)[9],,:,30%50%[10]ARF,ARF100%,2d[11],HIVCD4100/mL[2],AIDS(ART),,(IRIS)[2]Chang[12]13PC16,41.259.8,20.8d38.7d,8%44%,2.:PC,[10,12-14]66%,,530mm,,[14]23.88%,,80%,7012010191ChinJRespirCritCareMed,January2010,Vol.9,No.1©2002-2010EditorialDepartmentofChineseJournalofRespiratoryandCriticalCareMedicine.Allrightsreserved.(1):,25%,:(TBLB)(BAL)(),2537,37,,,,HE,,,,[15],,,,,,,1,,,,(PAS),Grocott(GMC),(MC)(2):,(CSF)BALF,(LA),,,,[16],,(3)CSF:CSF,,,,,,,,,,[17-20]1.:(1):,,36(A)(2):200400mg/d612(A),200400mg/d612(B)(3):0.71mgkg-1d-15-(5-FC)100mgkg-1d-12,400mg/d10,200mg/d612(A)2.(1):200400mg/d612(2):200400mg/d(A)400mg/d(C)400mg/d5-FC150mgkg-1d-110(C)B0.71mgkg-1d-1(B3mgkg-1d-1)5-FC100mgkg-1d-12,400mg/d10,200mg/d612(B)HIV,CD4200/mL6HIV,6,,AIDS,PCPC,,PC,খ㗗᭛⤂1JarvisJN,HarrisonTS.Pulmonarycryptococcosis.SeminRespirCritCareMed,2008,29:141-150.2MarroniM,PericoliniE,CenciE,etal.Functionaldefectofnaturalimmunesysteminanapparentimmunocompetentpatientwithpulmonarycryptococcosis.JInfect,2007,54:e5-8.3WarnockDW.Trendsintheepidemiologyofinvasivefungalinfections.NipponIshinkinGakkaiZasshi,2007,48:1-12.4ChenJ,VarmaA,DiazMR,etal.Cryptococcusneoformansstrainsandinfectioninapparentlyimmunocompetentpatients,China.EmergInfectDis,2008,14:755-762.5KhawcharoenpornT,ApisarnthanarakA,MundyLM.Non-neoformanscryptococcalinfections:asystematicreview.Infection,2007,35:51-58.6BernickerEH,AtmarRL,SchaffnerDL,etal.Unanticipateddiagnosesfoundatautopsyinanurbanpublicteachinghospital.AmJMedSci,1996,311:215-220.7MitchellDH,SorrellTC.PancoastssyndromeduetopulmonaryinfectionwithCryptococcusneoformansvarietygattii.ClinInfectDis,1992,14:1142-1144.8LehmannP,FMorganRJ,FreimerEH.InfectionwithCryptococcusneoformansvar.gattiileadingtoapulmonarycryptococcomaandmeningitis.JInfect,1984,9:301-306.9VilchezRA,LindenP,LacomisJ,etal.Acuterespiratoryfailureassociatedwithpulmonarycryptococcosisinnon-aidspatients.Chest,2001,119:1865-1869.10NadrousHF,AntoniosVS,TerrellCL,etal.Pulmonarycryptococcosisinnonimmunocompromisedpatients.Chest,2003,124:2143-2147.11LortholaryO,NunezH,BraunerMW,etal.Pulmonarycryptococcosis.SeminRespirCritCareMed,2004,25:145-157.8012010191ChinJRespirCritCareMed,January2010,Vol.9,No.1©2002-2010EditorialDepartmentofChineseJournalofRespiratoryandCriticalCareMedicine.Allrightsreserved.:comparisonofclinicalandradiographiccharacteristicsinimmunocompetentandimmunocompromisedpatients.Chest,2006,129:333-340.13YangCJ,HwangJJ,WangTH,etal.Clinicalandradiographicpresentationsofpulmonarycryptococcosisinimmunocompetentpatients.ScandJInfectDis,2006,38:788-793.14LindellRM,HartmanTE,NadrousHF,etal.Pulmonarycryptococcosis:CTfindingsinimmunocompetentpatients.Radiology,2005,236:326-331.15..,2005,27:244-246.16BaddleyJW,PerfectJR,OsterRA,etal.PulmonarycryptococcosisinpatientswithoutHIVinfection:factorsassociatedwithdisseminateddisease.EurJClinMicrobiolInfectDis,2008,27:937-943.17JarvisJN,DromerF,HarrisonTS,etal.Managingcryptococcosisintheimmunocompromisedhost.CurrOpinInfectDis,2008,21:596-603.18SaagMS,GraybillRJ,LarsenRA,etal.Practiceguidelinesforthemanagementofcryptococcaldisease.InfectiousDiseasesSocietyofAmerica.ClinInfectDis,2000,30:710-718.19AbergJA.Pulmonarycryptococcosisinnormalhosts:treatorobserve?Chest,2003,124:2049-2051.20ThurskyKA,PlayfordEG,SeymourJF,etal.Recommendationsforthetreatmentofestablishedfungalinfections.InternMedJ,2008,38:496-520.(:2009-04-08)ᴀߞৃⳈՓ⫼㣅᭛㓽ݭⱘᐌ⫼䆡∛AaDO2:-AHR:AIDS:ALI:APACHE:APTT:ARDS:ATS:BiPAP:BAL:BALF:BCG:BP:CAP:COPD:CVP:DLCO:DIC:ECG:ELISA:ERS:ESR:FVC:FEV1:1FDA:FiO2:GINA:GOLD:HAP:Hb:HE:-HIV:HR:ICU:IFN:IL:IPF:MIC:MODS:NPPV:NSCLC:OSAHS:P:PaO2/FiO2:PBS:PEEP:PaO2:PaCO2:Plt:PPD:%pred:RBC:R:RT-PCR:SaO2:SCLC:TBLB:VT:WBC:9012010191ChinJRespirCritCareMed,January2010,Vol.9,No.1