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Mar.200420(2)197204(ChineseJournalofNeuroanatomy)TRP(,,710032),,,;,[1]ö,Ca2+2,,(voltage2gatedcalciumchannel,VGCC),NMDAN,,,(ligand2gatedcalciumchannel,LGCC),,(receptor2activatedcalciumchan2nel,RACC)C(phospholipaseC,PLC)GPLCCPLC4,52(PIP2)(inosital1,4,52thisphosphate,IP3)(diacylglycerol,DAG),IP3ö(storedepletion),C(proteinkinaseC,PKC)RACC,(store2operatedcalciumchannel,SOCC)(receptor2operatedcalciumchannel,ROCC)[224],,(1)RACC,,T,RACC,SOCC,ROCCRACCTRP(transientreceptorpotential),PLC,RACCTRP,1.TRPTRP1975Minke[5],(transientreceptorpotential),,,,[6],,,,,[7]1989Montell[8]TRP,,TRP40%,TRP(TRP2like,TRPL)TRPTRPL,TRPL,;[9],TRPTRPL;,,TRP2.TRPTRPTRPL,EST,RT2PCR,TRPöTRPL(TRPC127)[10216],VRVRL[17,18],(ECaCöCaT1)(melastatin)[19,20]TRP,,,,20TRP,,,Harteneck[21]TRP:(STRPC)(LTRPC)TRP(OTRPC)TRPC127STRPC(STRPC127),VRVRLECaCöCaT1OTRPC(OTRPC123),melastatinLTRPC,MontellTRP,STRPCOTRPCLTRPCTRPC(TRPC127)TRPV(TRPV126)TRPM(TRPM128)[22],Ccanonicalclas2sical,TRPöTRPL;Vvanilloid,TRPV1vanil2loid();Mmelastatin,TRPM1TRPVTRPMTRP,,TRP,TRPTRP,(remoteTRPsub2families):TRPN,TRPPTRPMLTRPN,,TRPN,2000,TRPP,3,TRPMLIV,,TRP21TRPG,,IP3DAGIP3,(AA)(LA),TRPTRP(SOCE),(SOCC);DAGTRP(ROCE),(ROCC)3.TRPTRP,,,24(ankyrin),,TRPTRP,,öIP3,PKAöPKC,PDZTRP(TRPMs),C,TRP3TRPTRPC,TRP:TRPVC,TRPMN,TRPNTRP,N29;TRPPTRPML,TRP,,,TRP,(voltage2gatedionchannels,VGICs)A,TRP,VGICsA89120220043,TRP,TRP,TRPVGICs,2TRPCLUSTALWTRPC2,TRPC2TRP()d,hm(drosophila)(human)(mouse)4.TRP4.1,G(Gt),Gt(phosphodiesterase,PDE)cGMPGMP,cGMP,PLC,PLC,GqPLC,PIP2IP3DAGTRPöTRPL(1),TRPöTRPL?,,IP3IP3RTRPTRPLsf9,thapsigargin(Ca2+2ATP,SOCC)[23,24],,thapsigargin[25],IP3[26],DAG,rdgA,,Raghu[27]rdgAtrptrplrdgArdgADAG,DAG,rdgADAGTRPöTR2PLTRPTRPL,,DAGDAGPKC,PKC,[28],DAGDAG,TRPTRPL,PLC[29]DAG,DAGPIP2TRP[30],PIP2,PLCPIP2,PIP2DAGTRP,991:TRP4.2TRPCTRPCTRPVTRPM,TRPCTRPöTRPLPLC,SOCCROCC,TRPV,;TRPM,ADP(TRPM2)Mg2+öATP(TRPM7),TRPC,,TRPC,TRPC1TRPC2TR2PC4ö5TRPC3ö6ö74.2.1TRPC1TRPC1TRP,TRP40%,,[10]TPRC1COSCHO,thapsigargin[12,31],HSG(),(store2operatedcalciumentry,SOCE),SOCETRPC1cDNA[32]TR2PC1HSGSOCE,Vaca[33]TRPC1CHOSOCE,IP3öIP3RCa2+öCaMTRPC1SOCE,TRPC1,,,DAGOAGPKC[34],,Hoffmann[35],DAGTRPC14.2.2TRPC2TRPC2TRPC,1172,,TRP[11]NII(typeIIpolycystickidneydiseasegene),NTRPC2:,[11,36],,TR2PC2COSSOCE[11],TRPC2,[16]4.2.3TRPC4ö5TRPC1,,TRPC5mRNA[15],TRPC4,,[14],TRPC4ö5,()[37],TRPC5[15]TRPC4TRPC5HEK,GTPCSIP3thapsigargin,SOCC[14],TRPC4TRPC5HEK,G,[37]4.2.4TRPC3ö6ö7,(1ms),[35],TRPC3TRPC6,TRPC3,TRPC6[12,13],TRPC6[38]TRPC7,[16]TRPC,DAG[16,35]DAGN,TRPC6N54DAG[39]DAGTRPC3ö6ö7,,SOCC,Kiselyov[40],TRPC3TRPC3HEK,,carbachol(M),thapsigargin;,TRPC3IP3hep2arinIP3IP3,IP3RTRPC3IP3,IP3run2downTRPC3IP3RTRPC3,N[41]PLCIP3IP3R,2,IP3RTRP,TRPCCIP3R,TRPCPLC(IP3DAG)TRPC3ö6ö7,,?,Vazquez[42]TRPC3,TRPC3:,IP3R,;TRPC3,IP3R,00220220043DAG,,,TRPC,TRP,TRPCPLC,(),,,TRP,,5.TRP,TRPTRP,[21],,[43],TRP;öö,;TRP,5.1TRPCTRPCTRPöTRPL,(DAG),PLCRACC,TRPC4,TRPC4,(SOCE),NO,[44],SOCE,,[45]TRPC4,NO,,TRPC4TRPC4GABATRPC452HT2aR,,GABA,[46],TRPC6,TRPC6A1[38]TR2PC2,,[47]TRPC2,TRPC2,,[48],TRPC,TRPC3(BD2NF)[49];TRPC4PC12Cajal[50,51]5.2TRPVTRPV1,,,(pH5.9)(43),,TRPV1pH(ATP)()[17,52]TRPV1,,,[52,53]TRPV2TRPV3TRPV1,,TRPV1TRPV2TRPV35239[18,52,54]TRPV4OSM29,,,[52]TRPV4,,TRPV4MerkelMeissnerPenicillate,TRPV4,[55],TRPV,TRPV4TRPV123,TRPV4(27),[56]TRPV5TRPV6,[57],,,[52,57]102:TRP3TRPTRP(S12S6)N2C2,S5S6,N(ankyrin),C2TRP,EWKFARorVWKYQRTRP25,TRPVTRPV124,,,,(15),TRPM8ANKTM1[51]TRPM810%,828ANKTM1TRPTRPN4%,TRPV1,17,,,,5.3TRPMTRPMTRPM,(MLSN2S)[20],(MLSN2L)[58]MLSN2SMLSN2L,TRPM8TRPM5,[59],[60]TRPM,TRPM2ö6ö7,C[21,43]TRPM2,mRNA,TRPM2NAD+ADP,[61]TRPM7Mg2+öATP[62]DT240BTRPM7,TRPM7[62],TRPM,TRPM5[63],TRPM6,[64],TRPM8,[65]TRP,TRPSOCCROCC,,PLCTRPöTRPLPDZ(scaffoldprotein)INAD,TRPC1TRPC4caveolinNa+öH+(NHERF),,,,,,,,,,TRP,,TRP,,TRP,(2003-05-23)[1]BerridgeMJ,LippP,BootmanMD.Theversatilityanduniver2salityofcalciumsignalling.NatRevMolCellBiol,2000;1:1122120220220043[2]PutneyJWJr,BroadLM,BraunFJetal.Mechanismsofca2pacitativecalciumentry.JCellSci,2001;114:222322229[3]VenkatachalamK,vanRossumDB,PattersonRLetal.Thecellularandmolecularbasisofstore2operatedcalciumentry.NatCellBiol,2002;4:E263-E272[4]HofmannT,SchaeferM,SchultzGetal.Transientreceptorpotentialchannelsasmolecularsubstratesofreceptor2mediatedcationentry.JMolMed,2000;78:14-25[5]MinkeB,WuC,PakWL.InductionofphotoreceptorvoltagenoiseinthedarkinDrosophilamutant.Nature,1975;258:84-87[6]Suss2TobyE,SelingerZ,MinkeB.Lanthanumreducestheex2citationefficiencyinflyphotoreceptors.JGenPhysiol,1991;98:849-868[7]ReussH,MojetMH,ChybSetal.Invivoanalysisofthedrosophilalight2sensitivechannels,TRPandTRPL.Neuron,1997;19:1249-1259[8]MontellC,RubinGM.MolecularcharacterizationoftheDrosophilatrplocus:aputativeintegralmembraneproteinre2quiredforphototransduction.Neuron,1989;2:1313-1323[9]LeungHT,GengC,PakWL.Phenotypesoftrplmutantsandinteractionsbetweenthetransientreceptorpotential(TRP)andTRP2likechannelsinDrosophila.JNeurosci,2000;20:6797-6803[10]WesPD,ChevesichJ,JerominAetal.TRPC1,ahumanho2mologofaDrosophilastore2operatedchannel.ProcNatlAcadSciUSA,1995;92:9652-9656[11]VannierB,PeytonM,BoulayGetal.Mousetrp2,t