产品名:6-Aminonicotinamide修订日期:6/30/2016产品说明书化学性质产品名:6-Aminonicotinamide//struct//CasNo.:329-89-5分子量:137.1分子式:C6H7N3O别名:6-AN,NSC21206,SR4388化学名:6-amino-3-pyridinecarboxamideSMILES:Nc1ccc(cn1)C(=O)N溶解性:SolubleinDMSO储存条件:Storeat-20°C一般建议:Forobtainingahighersolubility,pleasewarmthetubeat37°Candshakeitintheultrasonicbathforawhile.Stocksolutioncanbestoredbelow-20°Cforseveralmonths.运输条件:Evaluationsamplesolution:shipwithblueiceAllotheravailablesize:shipwithRT,orblueiceuponrequest生物活性靶点:Metabolism信号通路:Dehydrogenase产品描述:Ki:0.46μM6-Aminonicotinamideisa6-phosphogluconatedehydrogenaseinhibitor.6-Phosphogluconatedehydrogenase,anenzymeinthepentosephosphatepathway,canproduceribulose5-phosphatefrom6-phosphogluconate.6-Phosphogluconatedehydrogenaseisalsoanoxidativecarboxylasecatalyzingthedecarboxylatingreductionof6-phosphogluconateintoribulose5-phosphateinthepresenceofNADP.Invitro:6-Aminonicotinamidecouldbemetabolizedto6-amino-NAD(P+),acompetitiveinhibitorofNAD(P+)-requiringprocesses,especiallythepentosephosphatepathwayenzyme,6-phosphogluconatedehydrogenase.Moreove,6-aminonicotinamideasasingleagentcouldcauseasignificantinhibitionofglycolyticfluxbuthadnoeffectonthepentosephosphatepathway.31P-NMRstudiesofperifusedRIF-1cellsindicatedthat4hofexposureto6-aminonicotinamidewasenoughtocausesignificantaccumulationof6-phosphogluconate,thesubstrateforthisenzyme[1].Invivo:Theinfluenceof6-aminonicotinamideontheG-6-P-DH-and6-PG-DH-levelsofthepentosephosphatepathwayinthekidneywasinvestigated.Followingi.p.administrationof6-aminonicotinamideat6mg/kg,the6-PG-levelrosefromavaluelessthan10nmoles/gto1000nmoles/gfreshweightwithin24h.Inaddition,attheendoftheassay,after7days,a6-PG-concentrationofabout150nmoles/gfreshweightwasstillseen.Moreove,theG-6-Plevelsimultaneouslyrosewiththe6-PG-leveltoabout150%ofthecontrollevelandreturnedtonormalonthe5thday[2].Clinicaltrial:Sofar,noclinicalstudyhasbeenconducted.参考文献:特别声明产品仅用于研究,不针对患者销售,望谅解。每个产品具体的储存和使用信息显示在产品说明书中。ApexBio产品在推荐的条件下是稳定的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的,运输温度不同于长期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后,按照产品说明书上的要求进行储存。ApexBioTechnology