3D-ASL脑灌注成像技术临床应用及研究进展

301PLAGH301医院放射科娄昕2014年4月11日郑州301PLAGH3DASL技术简介3DASL临床应用3DASL研究进展301PLAGH采用可弥散的示踪剂进行成像的方法15O-WaterPETXenonCTASLMRI99Tc-HMPAOSPECT（Microsphere-liketracers）采用不可弥散的示踪剂进行成像的方法CTPDSCMRI301PLAGH采用可弥散的示踪剂进行成像的方法15O-WaterPET放射性损伤、成本高XenonCT放射性损伤、舒适性差ASLMRI99Tc-HMPAOSPECT（Microsphere-liketracers）放射性损伤、半定量采用不可弥散的示踪剂进行成像的方法CTPDSCMRI301PLAGHPulsedASL(PASL)脉冲式ContinuousASL(CASL)连续式Pseudo-continuousASL(PCASL)准连续式SNRACCURACYSARPASL+++++CASL+++++++PCASL++++++++301PLAGH3DASL传统ASL采用EPI采集，磁敏感伪影明显2D采集，成像范围有限对运动伪影敏感采用FSE采集，有效克服磁敏感伪影3D采集，大范围成像Spiral采集高效快速，有效克服运动伪影图像信噪比明显提高图像质量不稳定301PLAGH3DASL临床应用3DASL技术简介3DASL研究进展301PLAGH脑膜瘤海绵状血管瘤301病例301PLAGH星形细胞瘤,WHOII级星形细胞瘤,WHOIII级301病例301PLAGH50岁，男性，脑干占位病变，平扫T2与T1加权像301病例301PLAGHCBF=109CBF=49DSC灌注3DASL301PLAGH51岁，男性，右顶叶占位病变术后，T2WI与DWI301病例301PLAGH术后增强DSC灌注301PLAGHCBF=85CBF=41DSC灌注3DASL301PLAGH治疗前治疗后49岁男性，右侧肢体力弱301病例301PLAGH3DASL显示溶栓治疗后过度灌注301PLAGHMELAS脑梗死LouX,MaL,etal.DifferentialDiagnosisofMELASandIschemicStrokeusing3DPseudocontinuousArterialSpinLabeling.ISMRMScientificMeeting,Italy,2014301病例301PLAGH3DASL临床应用3DASL技术简介3DASL研究进展301PLAGHN=8healthyvolunteers(7M,1F,27-41Y)PCASL,BS,3DspiralFSE3Scanson2scanners,10-15daysapartPLD=2.5SPLD=1.5S1sttest(scanner1)2ndtest(scanner2)3rdtest(scanner1)100806040200100806040200PLD=1.5SPLD=2.5S100806040200PLD=1.5SPLD=2.5SSubject1Subject2Subject3100806040200PLD=1.5SPLD=2.5SSubject4301PLAGHWuB,LouX*,WuXH,MaL.Intra-andinter-scannerreliabilityandreproducibilityof3Dwhole-brainpseudo-continuousarterialspin-labelingMRperfusionon3T.JMagnResonImaging.2014;39(2):402-9.301PLAGHHuangDD,WuB,ShiKN,MaLLouX*.ReliabilityofThree-dimensionalpseudo-continuousarterialspinlabellingMRimagingformeasuringvisualcortexperfusionontwo3Tscanners.PLOSONE.2013;8(11):e79471HuangDD,LouX*,MaL,etc.RSNA,2013,Oralpresentation301PLAGH301PLAGH16.5651.0442.2943.12PLD=1.5SPLD=2.5S301病例301PLAGHLouX,MaL.Can3DpCASLbeanotherpredictortoevaluatethecollateralPerfusioninPatientswithsevereintracranialarterialstenosis?ISMRMScientificMeeting,Italy,2014301病例301PLAGHHernandezDa,etc.Pseudocontinuousarterialspinlabelingquantifiesrelativecerebralbloodflowinacutestroke.Stroke.2012;43:753–8.WangDJ,etc.Thevalueofarterialspin-labeledperfusionimaginginacuteischemicstroke:comparisonwithdynamicsusceptibilitycontrast-enhancedMRI.Stroke.2012;43:1018–24.BokkersRPH,etc.Whole-brainarterialspinlabelingperfusionMRIinpatientswithacutestroke.Stroke.2012;43:1290–4.有很好的一致性CBF的侧值无明显差异ASL更有利于显示治疗后的过度灌注(luxuryperfusion)301PLAGHMusiekES,etc.DirectcomparisonoffluorodeoxyglucosepositronemissiontomographyandarterialspinlabelingmagneticresonanceimaginginAlzheimer'sdisease.AlzheimersDement.2012;8:51-9.301PLAGH脑发育过程中全脑CBF的变化脑发育过程中扣带回和枕叶的变化301PLAGHASL技术进行脑灌注成像准确无创在ASL技术中PCASL序列SNR高，SAR较低PCASL序列的可重复性好PCASL序列扫描参数选择中PLD是关键ASL临床应用范围广泛301PLAGH灌注成像在食物、药物药代动力学方面的应用Stateandtrait(phenotype/genotype)effects状态与特质（表型与基因型）效应对CBF的影响Perfusion-basedfMRI301PLAGH