CD40在T细胞介导的免疫反应中的作用

1007－8738201212－1341－03CD40-CD40L100700[e-mail]40CD40CD40L。CD40-CD40LTTCD8+TCD8+TCD4+T。CD40-CD40LTB、、B、CD4+CD25+Treg。CD40-CD40L、。CD40CD40LR392．11ACD4020q11-13Mr40000～500001cDNA831bp27762、22193。NGFR、TNFR、FasCD95TCD27TNFRNGFR1。CD40B、、、、、、、、、。CD40B、、。CD40gp39CD154Xq24-27Mr390002cDNA1783bp26122、24215。CD40L3Mr31000、18000140001。CD40-αtumornecrosisfactor-αTNF-α、-βtransforminggrowthfactor-βTGF-βTNF。CD40LCD4+TBCD8+T、、/、、、、B、、、。CD40L、、CD40L。CD40L。1CD40-CD40LCD40LCD4+CD8+TCD40LCD8+TCD40。CD40-CD40LCD4+TBB、APCT2。CD40-CD40LTAPCAPCCD40LCD40APCT、3。CD40-CD40L。CD40-CD40LCD40CD404。CD40-CD40L。CD40CD40LT。CD40CD40L、、5。2CD40-CD40L2．1TCD40-CD40LTAPCMHC/TTCD40LTCD40LAPCCD40APCB7-1B7-2T。CD40-CD40LAICDAPC。CD40APCT1431ISSN1007－8738ChinJCellMolImmunol20122812DOI:10.13423/j.cnki.cjcmi.006615。CD40-CD40LCD4+TCD25、CD40LIL-2IL-2CTLTTh1Th1IL-2、IFN-γCD40CD4+TCD8+CTLCD40LAPCCD40APC6。CD4+TCD8+TCD40CD40LAPC。CD40CD8+TTCD4+TCD8+TCD40CD4CD40CD8+T7。2．2T1-1-PD-L1CD8+TCD40-CD40LCD8+TCD8+TCD40CD8+T、TT-bet8。CD40CD4+TCD8+CTLCD40LAPCCD40APC9。IL-17CD4+TDCCD40-CD40LIL-17CD4+。CD40DCTh17CD40-CD40LIL-17CD40-CD40LTIL-6Th17、10。2．3TB16gp100TTgp100TB16gp100CD40mAbIL-2TadoptivelytransferedTcells。CD40CD80/CD86TCD40mAbIL-12T11。3CD40-CD40L3．1B、TB、CD40。BCD40LB、、B。CD4+TCD40LBCD40CD40-CD40LCD40-CD40LBBTD-AgTD-Ag、、Ig、、B。CD40mAbB12。TCD40LCD40+。FasFAS/APO。B。BBBCRBCRBBCRB9。3．2BZheng13CD40BCD40-BCD4+CD25+TregDCCD40-BTregDCTreg。CD40-BDCCD4+CD25+TregHLA-DRCD80B7-1、CD86B7-2。CD4+CD25+TregCD40-BIL-2。BTRag2－/－BAPCT。CD4+TBBCD40-CD40LCD40LCD4+TCD40BTB。APCBT14。3．3BBTD、CD40CD40LIgM、IgG、IgAIgE。IL-10CD40BIg。CD40-CD40LTB。CD4+TCD40CD40LTTBIgG、IgM、IgA。B、BCD40TCD40L。CD40LB。N-B、15。2431ISSN1007－8738ChinJCellMolImmunol201228124CD40-CD40L。、IgM、、、、、GVHD。1FoyTMAruffoABajorathJetal．ImmuneregulationbyCD40anditsligandGP39J．AnnuRevImmunol199614591－617．2SunYPengDLecandaJetal．InvivogenetransferofCD40ligandintocoloncancercellsinduceslocalproductionofcytokinesandchemokinestumoreradicationandprotectiveantitumorimmunityJ．GeneTherapy20007171467－1476．3CostelloRTGastautJAOliveD．WhatistherealroleofCD40incancerimmunotherapyJImmunolToday19992011488－493．4KarimiMHPourfathollahAA．CD40andtoleranceinductionJ．IranJAllergyAsthmaImmunol20121111－13．5KawabeTMatsushimaMHashimotoNetal．CD40/CD40ligandinteractionsinimmuneresponsesandpulmonaryimmunityJ．NagoyaJMedSci2011733－469－78．6JohnsonSZhanYSutherlandRMetal．SelectedToll-likereceptorligandsandvirusespromotehelper-independentcytotoxicTcellprimingbyupregulatingCD40LondendriticcellsJ．Immunity2009302218－227．7BourgeoisCRochaBTanchotC．AroleforCD40expressiononCD8+TcellsinthegenerationofCD8+TcellmemoryJ．Science200229755892060－2063．8BhadraRGigleyJPKhanIA．CuttingedgeCD40-CD40ligandpathwayplaysacriticalCD8-intrinsicand-extrinsicroleduringrescueofexhaustedCD8TcellsJ．JImmunol201118794421－4425．9KehryMR．CD40-mediatedsignalinginBcellsBalancingcellsurviv-algrowthanddeathJ．JImmunol199615672345－2348．10IezziGSondereggerIAmpenbergerFetal．CD40-CD40Lcross-talkintegratesstrongantigenicsignalsandmicrobialstimulitoinducedevelopmentofIL-17-producingCD4+TcellsJ．ProcNatlAcadSciUSA20091063876－881．11LiuCLewisCMLouYetal．AgonisticantibodytoCD40booststheantitumoractivityofadoptivelytransferredTcellsinvivoJ．JImmunother2012353276－282．12EricksonLDDurellBGVogelLAetal．Short-circuitinglong-livedhumoralimmunitybytheheightenedengagementofCD40J．JClinInvest2002109613－620．13ZhengJLiuYLauYLetal．CD40-activatedBcellsaremorepotentthanimmaturedendriticcellstoinduceandexpandCD4+regulatoryTcellsJ．CellMolImmunol20107144－50．14Rodriguez-PintoDMorenoJ．BcellscanprimenaiveCD4+Tcellsinvivointheabsenceofotherprofessionalantigen-presentingcellsinaCD154-CD40-dependentmannerJ．EurJImmunol20053541097－1105．15NadeauPJRoyAGervais-St-AmourCetal．ModulationofCD40-acti-vatedBlymphocytesbyN-acetylcysteineinvolvesdecreasedphosphorylationofSTAT3J．MolImmunol2012494檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾582－592．1340。3．5γ5129I≥55%CV≤5%≤80cpm。60s。3．6、4℃。1－20℃。3．76。。4。、。1．M．4．201069－70．2．M．2．201095－96．3．M．198551．4．M．2．2005184－185．5．M．4．201077．6．M．7．200851．3431ISSN1007－8738ChinJCellMolImmunol20122812