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,,,,MEDICALAPPLICATIONOFNANO-MATERIALSöJIANGHui2qing,CHENYi2fei.DepartmentofBurnandPlas2ticSurgery,NanjingGeneralHospitalofNanjingMilitaryCommand.NanjingJiangsu,P.R.China210002AbstractObjectiveToreviewtheresearchprogressandmedicalapplicationofnano2materials.MethodsTheliteraturereviewandcomprehensiveanalysis,methodswereusedinthisstudy.ResultsTheNanotechnologyisatypicalcrossingknowledge.Itcouldbeextensivelyappliedinthefieldsofnovelbiomaterials,effectivetransmissionofbioactivefactor;thedetectionoffunctionsforallvitalorgansystems,vascularcirculationcondition,thecontrolofrepairofburntraumawoundswillbemonitoredbythevariedmethodsofnanotechnologycombinedwithmolecularbiologicalengineering.ConclusionTheapplicationofNanotechnologywillplayimportantrolesinclinicalmedicine,woundrepairandbasicresearchforthetraditionalChinesemedicine.KeywordsNanomaterialsGenetherapyBio2medicalengineering20022(NationalNanotechnologyInitiative)21,,,,1100nm(10-910-7m),,,,,,,;,,,,,[1]21,,:(,210002),1,,,,,,,,,3mm,DNA(),DNA(),DNADNA,,DNADNA5342002166,,,[2]2(),,,,,,,,[3]31nm,,,,,,,,,,Kupffer,,,,100150nm,,Kupffer,,,,[4],,,,[5],(),,,,,,[6]4,DNA,,(),DNA,DNA50200nm,,,DNA[7]5,,,,,520mm[8],:,,,,,,,,[9]6,,,,Bonfield(1994),,[10],,71100m2,,2nm,,,10nm,,,[11],,8S-(clystallinesurfacelaysers,slayer,S2),S2,2.53510nm,28nm634ChineseJReparativeandReconstructiveSurgery,2002,Vol16(6),:S2S2;(,A),S2,,[12]9,,1cm2100,,100nm,12Lm,60Lm,,,,,,,,,,500,,,,[13]1991:,,21[14],,21101KeahlerT.Nanotechnology:Basicconceptsanddefinitions.ClinChem,1994;40(9):17972BukanovNO,DemidovVV,Nielsen,etal.PD2Loop:AcomplexofduplexDNAwithanoligonucleotide.ProcNarlSciUSA,1998;95(10):55163DavisSS.Biomedicalapplicationsofnanotechnology2implicationsfordrugtargetingandgenetherapy.TrendsBiotechnol,1997;15(6):2174PermiakovNK,AnanianMA,SorokovoiVI,etal.Scanningprobe2microscopyandmedico2biologicalnanotechnology:Historyandprospects.ArkhPotol,1998;60(5):95,,,..,2001;14(5):4396,,..,2001;15(6):3857SchofieldJP,CaskeyCT.Non2viralapproachestogenetherapy.BrMedBul,1995;51(1):568,,,..,2001;15(5):2809MurphyJ,CarrB,AtkinsonT.Nanotechnologyinmedicineandthebiosciences.TrendsBiotechnol,1994;12(8):28910,..,2001;12(4);20011..,1999;25(1):3012SleytrUB,PumD,SaraM.AdvancesinS2Layernanotechnologyandbiomimetics.AdvBiophs,1997;34:7113,..:,1994:10911014,..,1999;22(6):340(:2001207218:2002201230),1982,250,,,,,,:CN21-1160öR,:ISSN1001-1358:(399),:BM6787:,:8-162,16,64,6130,37180(),:79,:110005:024-23388257,:024-23389318:Ekxbjblin@yahoo.com.cn20022092257342002166