在放射治疗计划中应用蒙特卡罗剂量计算方法研究

20101171··【】。，。，，。，，。【】；；：R811.1：A：1674-4659（2010）01-0009-02ApplicationofMonteCarloDoseCalculationMethodintheRadiotherapyPlanningJINHaoyu1,ZHOULinghong2,CHENChaomin2(1DepartmentofMedicalInstruments,GuangdongFoodandDrugVocationalCollege,Guangzhou510520;2SchoolofBiomedicalEngineering,SouthernMedicalUniversity,Guangzhou510515)【Abstract】ObjectiveToverifythefeasibilityofapplicationofMonteCarlodosecalculationmethodintheradiotherapyplanning.MethodsWecompletedaradiotherapyplanningforaclinicalesophagustumorcase,andthedosecalculationwasaccomplishedbytheMonteCarlovirtualsourcemodel(VSM).ResultsThehighdoseareaisveryconformaltothePTV,andtheradiationinthekeyorganisverylittle.ConclusionTheresultsofdosevaluationindicatesthatthedosedistributionscalculatedbyVSMaccordwiththeprinciplesofradiotherapy.BecauseofVSM'saccuracy,itcantotallytaketheplaceofanalyticmodelswhichareappliedintheradiotherapyplanningsystemswidely.【Keywords】Radiotherapy;Dosecalculation;MonteCarlo1，2，2（1，510520；2，510515）（MonteCarlo，MC），。[1]，。1，BEAM/EGSnrc[2]，[1]，、，（、），。，。1.1，。、。，，。，，，，，，。1.2CT。5mm，450mm，512×512。，35，12。[3]CT，。X，Y，Z。，（voxel）。X、Y、Z5mm。，，、、、：2009-10-13：（2005B30301017）。：（1975－），，，，，。·9·20101171、。1.3，：45、90、135、240300。0.8，1。0。，，。，1，0。3001。130021.41cm（63.5cm），。21，，。，，。，。2。－（dose-volumehistogram，DVH）。6000cGy，100％。3CT。，（plantargetvolume，PTV），，30％，（3000cGy），，，。3CT4－－4。，。，100%90%，100%，，。OAR，NOR-MAL，PTV。3－1979Shipley，[4-6]。DVH，，，[7]，，DVH，，。34：，，。，，，，。[1]，，，.[J].,2006,27(21)：2002-2004.[2]RogersDWO,FaddegonBA,DingGX,etal.BEAM:AMonteCarlocodetosimulateradiotherapytreatmentunits[J].MedPhys,1995,22(3):503-524.[3]MaCM,RogersDWO,WaltersB.DOSXYZnrcUsersManual[R].NRCReportPIRS509b,2001.[4]Austin-SeynourMM,ChebGTY.Dosevolumehistogramanaysisofliv-erradiationtolerance[J].IntJRadiatOncolBiolPhys,1986,12(1):31-35.[5]LawrenceTS,TesserRJ,TenHRK.Anapplicationofdosevolumehistogramstotreatmentofintrahepaticmalignancieswithradiationtherapy[J].IntJRadiatOncolBiolPhys,1990,19:1041-1047.[6]DrzymalaRE,MohanR,BrewsterL,etal.Dose-volumehistograms[J].IntJRadiatOncolBiolPhys,1991,21:71-78.[7]HakenRKT,KesderM.UseofDVHs,TCPs,andNTCPsinTreatmentPlanning[M].//SternickES(ed).TheTheoryandPracticeofIntensity-ModulatedRadiationTherapy.ChapterH.Madison,WI,AdvancedMedicalPublishing,1997.（：）·10·