左旋肉碱的生理功能及在功能性食品中的应用-杨静

21Vol．2No．120121AgriculturalEngineeringJan．20122011-12-102012-01-12、。[e-mail]310058。。R151A2095-1795201201-0054-06PhysiologicalFunctionandApplicationofL-CarnitineinFunctionalFoodYangJingBiologicalSystemsEngineering＆FoodScienceCollegeZhejiangUniversistyHangzhou310029ChinaAbstractL-carnitineisanaturalsubstanceforhuman’sbodywhichcanspeedupthemetabolismsintransferringfattyacidsintoenergyandthiswaysupportsloseweightandrelativefunctions．InthispaperchemicalstructuresphysiologicalfunctionsandapplicationofL-carnitineinfunctionalfoodweresummarized．KeywordsL-carnitineChemicalStructurePhysiologicalfunctionsApplicationinfunctionalfood0L-carnitine、BT。。。50mg500mg。。、。、、。1-56-10。、、。11.1L、DDLLDLL。LDD。3--a--3R---3--4-β--γ-93R---3-hy-droxy-4-trimethylammoniobutanoateC7H15O3N162.2210～212℃αD20=－29.5～32.00200℃0.1H2O111。1Fig．1StrucuresofL-carnitinepHpH3～61200℃。、12。1.2、、。2①。、。20g。。2100mgkg。、。②。L-、、C、、B6、、513。13-14。、S-ε-4152。2Fig．2BiosynthesisofL-carnitineinvivo216-18。2.1CoACoA19CoACoA。CoACoA20-21。ACoACoACoAⅠⅡCoA223。3Fig．3L-Carnitinecarryfatacylintomitochondria2.2β-。23-24。β-25。1626。2.3。。27。。552.423。。、28。2.5、。29、。。2.619。2030。、19。26。。、31。3、。、。。、、、32-37。。3.1、“”。5%～25%38。。39。β-。4041。、、、14。3.2、42。15%。。43。。70～90mgkgGB14880-199422。3.365。。、—。。44。3.4FDAADI20mgkg·d－11200mg13。。。。50mg20mg。5mg。3.5β-。20%。。L-7.5～10g、、。、。45。3.6metabolicsyndromeMSII46-47。。。48249+、、50。3.7。。511073。。28。4、。、。。。1．-J．200621618-23．75HuMenghongWangYouji．TheprospectofL-carnitineasaaddi-tiveinfishdietsJ．ModernFisheriesInformation200621618-23．2．L-J．20061227-31．3．L-J．2006271056-58．LiHaijunShaoQingjunNieYuemei．ApplicationofL-carnitineinmarinelivesJ．FeedIndustry2006271056-58．4．L-J．200535519-21．5．、L-J．2005417-19．6．J．20052691225-1226．7．J．200711654-655．8．CJ．20052111640．9．J．200518S156．10．-J．2005276433-435．WangLuWangKepingYuChangqingetal．L-carnitineeffectsonanemiainuremicpatientstreatedwitherythropoietinJ．JournalofDalianMedicalUniversity2005276433-435．11．L-J．2006313136-139．WangYuanyangZhaoYanhua．CurrentsituationaboutthestudyofL-carnitineanditsapplicationJ．FoodScienceandTechnolo-gy2006313136-139．12．J．2005384-85．13．J．20051037-39．14GoudriaanJRDenBoerMARensenPCetal．CD36defi-ciencyinmiceimpairslipoproteinlipase-mediatedtriglycerideclear-anceJ．JLipidRes2005462175-2181．15．J．201117152356-23572360．FanJingjingLvChaoTengWenjiaoetal．DevelopmentofthestudiesonrelationshipsbetweenL-carnitineandmetabolicsyndromeJ．MedicalRecapitulate201117152356-23572360．16BremerJ．CarnitinemetabolismandfunctionsJ．PhysiolRev1983631420-1480．17KanekoTYoshidaR．OntheabsoluteconfigurationofL-carnitineJ．BullChemSocJpn1962351153-1155．18．D．2006．JiangHeng．ProtectiveeffectsofL-carnitineonthecisplatin-in-ducedkidneydamageinratsD．ChongqingThirdMilitaryMedicalUniversity2006．19JiHBradleyTM．AtalanticsalmonsalmonsalarfedL-carnitineexhibitalteredintermdiarymetabolismandreducedtissuelipidbutnochangeingrowthrateJ．JournalofNutrition199612681937-1950．20JeltjeRGoudriaanMarionAMdenBoerPatrickCNRensenetal．CD36deficiencyinmiceimpairslipoproteinlipase-mediatedtriglycerideclearanceJ．TheJournalofLipidResearch2005462175-2181．21．L-J．2005941-43．LiuXiaogengWangSiqing．ProgressinstudiesandapplicationofL-carnitineJ．JournalofCereals＆Oils2005941-43．22．J．2005137556-558．23BrassEPBeyerinckRA．Effectsofpropionateandcarnitineonthehepaticoxidationofshort-andmedium-chainlengthfattyacidsJ．BiochemJ1988250819-825．24ColquhounA．Inductionofapoptosisbypolyunsaturatedfattyacidsanditsrelationshiptofattyacidinhibitionofcarnitinepalmitoyltrans-feraseIactivityinHep2cellsJ．BiochemMolBiolInt199845331-333．25HelmsR．EnhancedlipidutilizationininfantsreceivingoralL-cam-itineduringlong-termparenternutritionJ．JPediat1986109984．26．、J．200635427-2836．MaLiMaJianfeiDingHongetal．EffectsofL-carnitineonproliferationapoptosisandfibronectinsecretionofhumanperito-nealmesothelialcellsunderhighglucoseconditionJ．JournalofChinaMedicalUniversity200635427-2836．27．J．2011117740-742．ZhouXiaoyanChenJingLiuChangxiuetal．Empiricalstudyonanti-fatigueeffectofL-CarnitineJ．JournalofTropicalMedi-cine2011117740-742．28．J．2005219994-995．29KanterMMWilliamsMH．AntioxidantscarnitineandcholinesasputativeergogenicaidsJ．IntJNutr199556120-131．30．J．20051110761-764．LiZhengChenGuowuShangXuejunetal．Acontrolledran-domizedtrialoftheuseofcombinedL-carnitineandacetyl-L-carni-tinetreatmentinmenwitholigoasthenozoospermiaJ．NationalJournalofAndrology20051110761-764．31．L-J．2006625-27．32．L-J．201026283-96．ZhangBaohua．TheinfluenceofL-carnitineonthebodyshapeofwomenJ．JournalofShanxiDatongUniversityNaturalScienceEdition201026283-96．33．85J．20071316-8．HuangZongxiuLinJianLinChunfang．AssessmentofL-carni-tine＇sweightcontrolfunctioninobesepopulationJ．PreventiveMedicineTribune20071316-8．34．－J．20042624-26．35．、L－J．20109129-31．FanXueYanZheng．TheeffectoforganicchromiumL-carnitineandaerobicsexerciseonthelipidmetabolismofratswithhighfatdi-etJ．JournalofNanjingInstituteofPhysicalEducationNaturalScience20109129-31．36．2J．2000213215-218．LiYanbingLiangYiquanQinWanwenetal．L-carnitineino-verweighttypy2diabetesmellitusJ．JournalofSunYat-SenUn