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3220103JournalofHydroecologyVol.3,No.2Mar.,2010:2009-10-21:(PC20081050);(2009B030600006):E-mail:fangzhq@scnu.edu.cn:,1983,,,,E-mail:hanjian251314@163.comPFOSPFOA,(,510631):(PFOS)(PFOA)(POPs),PFOSPFOAPFOSPFOA,PFOSPFOA,PFOSPFOA:;;;:X52:A:1674-3075(2010)02-0099-07,,,,;(persistentorganicpollutants,POPs),(peifluorooctanesulfonate,PFOS)(perfluorooctanoicacid,PFOA),,,,,,(EPA)(POPs),(Perfluoroalkyl,2007)(UNEP)(PFOS),,,11.1PFOSPFOS,(PFOSF),,,,//1.2PFOAPFOA,(perfluorinatedalcohol),PFOA;(Fluorotelomer)PFOAPFOA,,(polytetraflu2oroethylene,PTFE,)1.32006,8()EPAPFOA,PFOA,2015PFOA3M2002PFOS,20074PFOS22.1PFOSPFOANobuyo2shi(2005),(,),,PFOAPFOS2Hansen(2002)40,PFOS;PFOS1754ng/L,,75144ng/L,3M4(),PFOA,PFOA,PFOS(Saitoetal,2003)SO(2004)()PFOS0.093.100.0212.000.04730.00ng/L,PFOA0.735.50.24160.24320pg/mL,;,PFOS,0.9099ng/L,PFOA0.8513ng/L;PFOS0.0114ng/L,PFOA2.0260ng/L,(Soetal,2007);(2004)PFOS,PFOSPFOA,PFOS/PFOA37.8ng/L298ng/L,PFOSPFOA(,2006);(2007)PFOSPFOA,0.068.04ng/L0.022.68ng/L;Houde(2006),PFCs0.010.4ng/g;(2006)/-PFOSPFOA,180818g/g,PFOS/PFOAPFOS(693700ng/g)PFOA(112500ng/g),PFOSPFOA(Moriwakietal,2003)(2007)200626PFOSPFOA,PFOSPFOA2.0ng/L(0.446.2ng/L)3.6ng/L(1.622.4ng/L),()PFOS/PFOA2,PFOS/PFOA;PFOS/PFOA;PFOS/PFOA,,(DeSilvaetal,2006)2.22.2.1Kannan(2002)175,,PFOS(61ng/g)PFOA(95ng/g);PFOA878ng/g,PFOS1301100ng/g,,PFOS,27,PFOS(0.31319ng/g),,(Gulkowskaetal,2006)PFOSPFOA,PFOS,()(0.280109)ng/g,(20.23.9)ng/g,40%PFOA,PFOS,,(2.60.3)ng/gPFOS,(0.4910)N-EtPFOSAPFOSAPFOS,(Tomyetal,2004)PFOSPFOA,PFOS0013220103,PFOAPFOS;PFOS/PFOA(Kannanetal,2005)2.2.2PFOA,();();300g/kg(Begleyetal,2005)PFOS/PFOA,PFOS3220ng/kg.d,PFOA1130ng/kg.d,,(Trudeletal,2008)2.2.3PFOSPFOAHeuvel(1991)14CPFOA,PFOA(91%,1d;6%,15d);PFOA(,);,PFOA1%;,PFOA;,PFOA-,PFOA,,PFOA,,PFOA,PFOA33.1PFOS/PFOA,PFOA,(LD50)500mg/kg250500mg/kg(GlazaSM)Olson&Andersen(1983)FischerPFOAPFOA,PFOS,LD5020mg/kg,LC50512mg/L(1h),,,3.2PFOS/PFOAPFOA39d(Pimephalespromelas),,,PFOA,(Oakesetal,2004)1mg/LPFOS2PFOS(21d,95%)0.23mg/L0.3mg/LPFOS21d,,11-;0.03mg/L24d,PFOS(),PFOS23,(Ankleyetal,2005)Liu(2007),PFOSPFOAFTOH(426282),,(vitellogenin,VTG),;(estrogenrecep2tor,ER)VTG,;,VTGVTGER,PFOAVTGER,(Yanhongetal,2007)3.3PFOS/PFOAPFOA(5mg/kg,117d),(Wolfetal,2007)4dPFOS(0.10.5135mg/L),3,,3mg/L5mg/L(hhex,10120102,PFOSPFOApax8),(cyp19acyp19b)(Shietal,2008)3.4PFOS/PFOAWistar,PFOS[Ca2+]i,[Ca2+]iPFOS(r=01929,P0105)(,2005)PFOS,WistarPFOS,50100200mg/kg,24h(Glu-IRPC),(P0.01)(,2004)Glu(EAAR),Ca2+,Ca2+,,PFOS;,PFOS/PFOA,(Johanssonetal,2008)3.5PFOS/PFOAYang(2000)C57BL/6PFOA,,,90%,CD4+CD8+;50%,PFOA;,PFOA,;,10d5d,,,(Yangetal,2001)Zheng(2009)PFOS(052040mg/kgd)C57BL/67d,,,,;2,,NK-cell3.6PFOS/PFOAPFOA,PFOA,50010638,(Keerthietal,2006),PFOS240480,PFOA290320,(Yeungetal,2007)PFOAHepG2,50400mol/LPFOAHepG21h,DNA100400mol/LPFOAHepG224h,100400mol/LPFOA3h,8-OHdG(,2005)3.7PFOS/PFOAPFOS/PFOA,PFOSPFOA,PFOAPFOS(Kannanetal,2005)PFOA,PFOS,,Cyp17a1PFOS,PFOA4;Cyp3a11/18PFOS,PFOA;Cyp2j4PFOS/PFOA,PFOS/PFOA(Keerthietal,2006),PFOS,PFOA,,,PFOS5mg/kgdPFOA,Acaa1PFOSPFOA2(Huetal,2005),PFOS,;PFOS,PFOAG-(Huetal,2002;Huetal,2003),PFOSPFOA,20132201033.8Perfluorinatedorganiccompounds(PFCs),PFOSPFOA,PFBAPFDAPFNAPFTAPFDoAPFHxSPFBSFTOHBao(2009)8PFCs,,PFOS/PFOA,PFDAPFNAPFTAPFDoAPFHxSPFBS;Li(2008),PFOS(5.7464.2ng/mL),PFDAPFOSA;Wei(2009)PFOAPFNAPFDAPFDoAPFOSFTOH(82),,,PFNA,,PFNA;,Bcl-2PFNA(Fangetal,2009)POPs4,,,,(),,,PFOS/PFOA,,,,,,,,PFOS/PFOA,PFOS/PFOA,(),,,PFOS/PFOA,,(,2007;,2007),:(1)PFOS/PFOA,;(2),;(3),;(4),,,;(5),,,,,,,,:,,.2007.185nm[J].,28(4):772-776.,,.2006./-[J].,25(6):674-677.,,,.2006.PFOSPFOA[J].,15(3):486-489.,,,.2004.PFOS[J].,24(2):166-169.,.2004.[J].,18(4):232-233.,,,.2007.[J].,27(3):480-486.,,,.2005.[J].,19(3):225-226.,,,.2007.PFOSPFOA[J].,28(9):2068-2073.,,,.2007.[J].,2930120102,PFOSPFOA(8):588-594.,.2005.HepG2DNA[J].,19(3):216-217.AnkleyGT,KuehlDW,KahlMD,etal.2005.Reproductiveanddevelopmentaltoxicityandbioconcentrationofperfluo2rooctanesulfonateinapartiallife2cycletestwiththefatheadminnow(Pimephalespromelas)[J].EnvironToxicolChem,24(9):2316-2324.BaoJ,JinY,LiuW,etal.2009.PerfluorinatedcompoundsinsedimentsfromtheDaliaoRiversystemofnortheastChina.Chemosphere,77(5):652-657.BegleyTH,WhiteK,HonigfortP,etal.2005.Perfluorochem2icals:potentialsourcesofandmigrationfromfoodpacka2ging[J].FoodAdditContam,22(10):1023-1031.ChunshengLiu,YongbingDu,BingshengZhou.2007.Evalua2tionofestrogenicactivitiesandmechanismofactionofper2fluorinatedchemicalsdeterminedbyvitellogenininductioninprimaryculturedtilapiahepatocytes[J].AquaticToxicolo2gy,85:267-277.DeSilvaAO,MaburySA.2006.Isomerdistributionofperfluo2rocarboxylatesinhumanblood:Potentialcorrelationtosource[J].EnvironmentalScienceandTechnology,40(9):2903-2909.FangX,FengY,ShiZ,etal.2009.AlterationsofCytokinesandMAPKSignalingPathwaysareRelatedtotheImmunotoxicEffectofPerfluorononanoicAcid[J].ToxicologicalSci2ences,108(2):367-37.GlazaSM.AcuteoraltoxicitystudyofT26669inrats[Z].Cor2ningHazaltonInc,CHW61001760.GulkowskaA,JiangQ,SoMK,etal.2006.PersistentPerflu2orinatedAcidsinSeafoodCollectedfromTwoCitiesofChi2na[J].EnvironSciTechnol,40:3736-3741.H