蛹虫草化学成分及药理作用研究进展-万朋

2015496SH．J．TCMJun．2015Vol．49No．6DOI10．16305/j．1007-1334．2015．06．033112132013【】。、、、、、。【】ResearchprogressofcomponentandpharmacologicaleffectsofCordycepsMilitarisWANPengGAOJun-taoLUShi-jieJilinMedicalCollegeAbstractThispapersummarizestheresearchdevelopmentonthechemicalcompositionpharmacologicaleffectsofCordycepsMilitaris．ThemainingredientsofCordycepsMilitarisarenucleosideacidpolysaccharidecaterpillarfunguscordycepinsterolsaminoacidsandtraceelementsetc．andtheirpharmacologicaleffectsarewidely．TheeffectsofCordycepsMilitarisonthenervoussystemcirculatorysystemandimmunesystemareremarkable．KeywordsCordycepsMilitariscordycepicacidcordycepinpharmacologicalacitonreviewWL20130120130412002XH。[e-mail]、、。。、1。2。。。11．1、、3’-、3’-3’-、3-4。1．2。CMPS。CMPS5。、、、6-7。1．3、、、8。。9。1．410。HPLC-ESI-MS、11。、、。12。1．5D2。13-14。1．6ICP-AESP、KMg、Ca、Zn、Fe、Na、CrCu、Mn、Ni、AsP·59·2015496SH．J．TCMJun．2015Vol．49No．6Ni、Ca、Fe、Cu、Mn、Zn、K、Co、Cr15。1．7、、、、、、、、、、、、、、、、、、。16。22．1、、。。β-17。γ--418。2．2。SOD19。、57．14%E20。A1/A221。2．3D-22。、、、23。CFe2+24。2．4。20ml/kg20mg/kg25。2．5ATP。、、、26。2．6B16-BL6LLCHT1080CW27。28。DNARNA、29。S180LewisLewis30。31。3、、、。。、。、。1PatersonRR．CordycepsAtraditionalChinesemedicineandanotherfungaltherapeuticbiofactoryJ．Phytochemistry20086971469-1495．2．J．200216450-53．3．J．2002282168-172．4HsuTHShiaoLHHsiehCYetal．AcomparisonofthechemicalcompositionandbioactiveingredientsoftheChinesemedicinalmushroomDongChongXiaCaoitscounterfeitandmimicandfermentedmyceliumofCordycepssinensisJ．FoodChemistry2002784463-469．5．J．2000175361．6ZhangJYuYZhangZetal．EffectofpolysaccharidefromculturedCordycepssinensisonimmunefunctionandanti-oxidationactivityofmiceexposedto60CoJ．IntImmunopharmacol201111122251-2257．7YanFZhangYWangBB．EffectsofpolysaccharidesfromCordycepssinensismyceliumonphysicalfatigueinmiceJ．BangladeshJPharmacol201273217-221．·69·2015496SH．J．TCMJun．2015Vol．49No．68．J．200635144-46．9．J．200113296-97．10．J．2004273215-217．11．HPLC-ESI-MSJ．2004298762-764．12TsaiYJLinLCTsaiTH．PharmacokineticsofadenosineandcordycepinabioactiveconstituentofCordycepssinensisinratJ．JAgricFoodChem20105884638-4643．13RaoYKChouCHTzengYM．AsimpleandrapidmethodforidentificationanddeterminationofcordycepininCordycepsmilitarisbycapillaryelectrophoresisJ．AnalyticaChimicaActa20065662253-258．14．RP-HPLCJ．2001184297-299．15．J．2013302779-781．16．J．2003136105-107．17KoBSLuYJYaoWLetal．CordycepinregulatesGSK-3b/b-cateninsignalinginhumanleukemiacellsJ．PLoSOne20138e76320-76326．18WangMMengXYangRetal．CordycepsmilitarispolysaccharidescanimprovetheimmuneefficacyofNewcastlediseasevaccineinchickenJ．IntJBiolMacromol2013598178-183．19QiWWangPJGuoWJetal．ThemechanismofCordycepssinensisandstrontiuminpreventionofosteoporosisinratsJ．BiolTraceElemRes20111431302-309．20QiWYanYBLeiWetal．PreventionofdisuseosteoporosisinratsbyCordycepssinensisextractJ．OsteoporosInt20122392347-2357．21WonKJLeeSCLeeCKetal．Cordycepinattenuatesneointimalformationbyinhibitingreactiveoxygenspecies-mediatedresponsesinvascularsmoothmusclecellsinratsJ．JPharmacolSci20091093403-412．22PengYChenQYangTetal．CulturedmyceliumCordycepssinensisprotectsliversinusoidalendothelialcellsinacuteliverinjuredmiceJ．MolBiolRep20144131815-1827．23ChaJYAhnHYChoYSetal．Protectiveeffectofcordycepin-enrichedCordycepsmilitarisonalcoholichepatotoxicityinSprague-DawleyratsJ．FoodChemToxicol2013601052-57．24LiuZLiPZhaoDetal．ProtectiveeffectofextractofCordycepssinensisinmiddlecerebralarteryocclusion-inducedfocalcerebralischemiainratsJ．BehavBrainFunct20106661-63．25．J．1987226-9．26．M．2005．27YoshikawaNNishiuchiAKuboEetal．CordycepssinensisactsasanadenosineA3receptoragonistonmousemelanomaandlungcarcinomacellsandhumanfibrosarcomaandcoloncarcinomacellsJ．PharmacolPharm2011132266-270．28ZhouXMeyerCUSchmidtkePetal．Effectofcordycepinoninterleukin-10productionsofhumanperipheralbloodmononuclearcellsJ．EuropJPharmac20024532-3309-317．29TuliHSSharmaAKSandhuSSetal．CordycepinabioactivemetabolitewiththerapeuticpotentialJ．LifeSci20139323863-869．30ThakurAHuiRHongyanZetal．Pro-apoptoticeffectsofPaecilomyceshepialiaCordycepssinensisextractonhumanlungadenocarcinomaA549cellsinvitroJ．JCancerResTher201174421-426．31ParkSEYooHSJinCYetal．InductionofapoptosisandinhibitionoftelomeraseactivityinhumanlungcarcinomacellsbythewaterextractofCordycepsmilitarisJ．FoodChemToxicol．20094771667-1675．:2015-03-16·79·