针刺治疗缺血性中风

Acupuncture针刺或者翻译成针灸IschemicStroke缺血性中风第一批五篇文章（英文）1.NeuralRegenRes.2015Dec;10(12):1997-2003.doi:10.4103/1673-5374.172318.Acupunctureforischemicstroke:cerebellaractivationmaybeacentralmechanismfollowingDeqi.译文：针刺治疗缺血性中风：小脑激活可能是继DeQi之后的另一个中央机制LiMK(1),LiYJ(2),ZhangGF(3),ChenJQ(4),ZhangJP(1),QiJ(1),HuangY(1),LaiXS(5),TangCZ(5).Authorinformation:(1)SchoolofChineseMedicine,SouthernMedicalUniversity,Guangzhou,GuangdongProvince,China.(2)FirstClinicalMedicalSchool,SouthernMedicalUniversity,Guangzhou,GuangdongProvince,China.(3)ZhaoqingMedicalCollege,Zhaoqing,GuangdongProvince,China.(4)DepartmentofRehabilitationMedicine,theThirdAffiliatedHospitalofSouthernMedicalUniversity,Guangzhou,GuangdongProvince,China.(5)CollegeofAcupunctureandMassage,GuangzhouUniversityofChineseMedicine,Guangzhou,GuangdongProvince,China.TheneedlingsensationofDeqiduringacupunctureisakeyfactorofinfluencingacupunctureoutcome.RecentstudieshavemainlyfocusedonthebrainfunctioneffectsofDeqiinaphysiologicalstate.Functionalmagneticresonanceimaging(fMRI)ontheeffectsofacupunctureatWaiguan(SJ5)inpathologicalandphysiologicalstatesiscontroversial.Inthisstudy,12patientswithischemicstrokereceivedacupunctureatWaiguan(SJ5)andsimultaneouslyunderwentfMRIscanningofthebrain,withimagingdataoftheactivatedareasobtained.Basedonthepatient'ssensation,imagingdatawereallocatedtoeithertheDeqigroupornon-Deqigroup.IntheDeqigroup,theactivated/deactivatedareasweretheleftsuperiortemporalgyrus(BA39)/rightanteriorlobeofthecerebellumandleftthalamus.Inthenon-Deqigroup,theactivatedareasincludedthemedialfrontalgyrusoftherightfrontallobe(BA11),rightlimbiclobe(BA30,35),andleftfrontallobe(BA47),whiletheonlydeactivatedareawastherightparietallobe(BA40).Comparedwiththenon-Deqigroup,theDeqigroupexhibitedmarkedactivationoftherightanteriorlobeofthecerebellumandrightlimbiclobe(BA30).ThesefindingsconfirmthattheclinicaleffectofDeqiduringacupunctureisbasedonbrainfunctionalchanges.Cerebellaractivationmaybeoneofthecentralmechanismsofacupunctureinthetreatmentofischemicstroke.译文：在针刺治疗过程中对DeQi的针感（needlingsensation）是针刺治疗效果的关键。近期的研究主要是关注在一个生理状态下DQ对脑功能的影响。功能性磁共振成像对于研究外关（穴位可能是）在生理和病理的影响这种方法是有争议的。在本项研究中，12例缺血性中风病人接受对外关的针刺（或者翻译为针灸），同时利用功能性磁共振成像进行脑部扫描，获取激活区域的图像数据。根据病人的反应，成像数据别分成进行DQ针刺和未进行DQ针刺两组。在接受DQ穴位针刺的一组中，激活区域和非激活区域分别位于小脑和左丘脑的左颞回和右前叶。在未接受DQ针刺的一组中，激活区域包括右额叶、右边缘页、左额叶的中央前回，而非激活区域只有右顶页。与非进行DQ针刺治疗的小组相比，进行DQ针刺的小组患者小脑和右边缘页的右前页激活明显。基于脑功能的改变，这些研究证实了对DQ针刺的临床效果。小脑激活可能是对于缺血性中风治疗的针刺的核心机制之一。PMCID:PMC4730825PMID:26889189[PubMed]2.SciRep.2016Jan20;6:19521.doi:10.1038/srep19521.Acupunctureforneurogenesisinexperimentalischemicstroke:asystematicreviewandmeta-analysis.针刺对于实验性缺血性中风的神经再生的系统评价和荟萃分析（或者叫做元分析，一种分析方法）LuL(1,)(2),ZhangXG(2),ZhongLL(1),ChenZX(2),LiY(2),ZhengGQ(2),BianZX(1).Authorinformation:(1)SchoolofChineseMedicine,HongKongBaptistUniversity,HongKongSAR,China.(2)DepartmentofNeurology,theSecondAffiliatedHospitalandYuyingChildren'sHospitalofWenzhouMedicalUniversity,Wenzhou325027,China.Acupuncturehasbeenusedforpatientswithstrokeandpost-strokerehabilitationforthousandsofyears.Previousstudiesreportedthatacupunctureenhancedstrokerecoverythroughneurogenesis.Hence,weconductedasystematicreviewandmeta-analysisforpreclinicalstudiestoassessthecurrentevidenceforacupunctureeffectonneurogenesisintreatingischaemicstroke.Studieswereobtainedfromsixdatabases,includingPubMed,EMBASE,CochraneLibrary,ChineseNationalKnowledgeInfrastructure,VIPinformationdatabase,andChineseBiomedicalLiteratureDatabase,Ultimately,34studiescontaining1617animalswereidentified.NeurogenesismarkersofBrdu,Nestin,PSA-NCAM,NeuNandGFAPwereselectedasmajoroutcomes.Thepooledresultsof15studiesmarkedwithBrdushowedsignificanteffectsofacupunctureforimprovingproliferationwhencomparedwithcontrolgroups(P  0.01);13studiesmarkedwithNestinshowedsignificanteffectsofacupunctureforincreasingproliferationwhencomparedwithcontrolgroups(P  0.01);4studiesmarkedwithPSA-NCAMshowedsignificanteffectsofacupunctureforenhancingmigrationwhencomparedwithcontrolgroups(P  0.01);4studiesmarkedwithNeuNshowedsignificanteffectsofacupunctureforstimulatingdifferentiationwhencomparedwithcontrolgroups(P  0.01).Thefindingssuggestthatacupunctureisaprospectivetherapytargetingneurogenesisforischemicstroke.译文：几千年以来，针灸已经被用来治疗中风和中风的复原。之前的研究表明，针灸能够通过神经再生，加强中风的恢复。因此，我们对临床前研究进行了系统回顾和荟萃分析，来评估目前对于针刺治疗缺血性中风效果的证据。这些研究来自于六个数据库，包括PubMed、EMBSAE(还有其他的一大堆机构，不一一赘述)。神经再生的主要标记物选择Brdu(尿苷)、nesting（巢蛋白）、PSA-NCAM、免疫荧光标记。与对照组对比（P0.01）,标记尿苷的15项研究的汇总结果表明针灸对于提高增殖速度具有显著的效果；与对照组对比（P0.01），标记巢蛋白的13项研究结果表明针灸治疗对于提高增殖速度有显著效果；与对照组对比（P0.01），标记PSA-NCAM4项研究表明，针刺治疗对于提高活动具有显著影响；与对照组对比（P0.01），标记NeuN的4项研究结果表明针灸对刺激分化具有显著效果。这些研究结果表明，针刺是一个对于缺血性中风治疗具有前瞻性的方法。PMCID:PMC4726177PMID:26786869[PubMed-inprocess]3.EvidBasedComplementAlternatMed.2015;2015:164792.doi:10.1155/2015/164792.Epub2015Oct20.TheEffectofAcupunctureontheMotorFunctionandWhiteMatterMicrostructureinIschemicStrokePatients.针刺对于缺血性中风病人运动功能和脑白质微观结构的影响LiY(1),WangY(1),ZhangH(2),WuP(3),HuangW(1).Authorinformation:(1)InstituteofClinicalAnatomy,SchoolofBasicMedicalSciences,SouthernMedicalUniversity,G