第十章《T淋巴细胞》练习题

1第十章《T淋巴细胞》练习题一、单选题1．下列不属于Th1型细胞因子是··············································（）A、IL-2B、IL-4C、TNFD、IFN-γ2．临床上用于鉴别T细胞的表面标志是········································（）A、CD2B、CD3C、CD4D、TCR3．胞质区含有ITAM基序的CD分子是·········································（）A、CD3B、CD4C、CD28D、CD152（CTLA-4）4．HIV包膜蛋白gp120受体是················································（）A、CD2B、CD3C、CD4D、CD85．与MHCⅡ类分子结合的CD分子是··········································（）A、CD3B、CD4C、CD8D、CD286．与MHCⅠ类分子结合的CD分子是··········································（）A、CD3B、CD4C、CD8D、CD287．MHCⅡ类分子与CD4分子结合的结构域是···································（）A、α1结构域B、β1结构域C、α2结构域D、β2结构域8．MHCⅠ类分子与CD8分子结合的结构域是···································（）A、α1结构域B、α2结构域C、α3结构域D、β2结构域9．胞质区含有ITIM，能与CD80/CD86结合的CD分子是··························（）A、CD3B、CD28C、CD152D、CD210．下列不属Th2型细胞因子是···············································（）A、IFN-γB、IL-4C、IL-10D、IL-511．通过分泌IL10和TGF-β对免疫应答发挥负调节的T细胞是·····················（）A、Th1B、Th2C、Th3D、Tr112．主要识别外源性抗原肽-MHCⅡ类分子复合物，受MHCⅡ类分子限制的细胞是····（）A、CD4＋T细胞B、CD8＋T细胞C、T细胞D、T细胞13．主要识别内源性抗原肽-MHCⅠ类分子复合物，受MHCⅠ类分子限制的细胞是···（）A、CD4＋T细胞B、CD8＋T细胞C、T细胞D、T细胞14．关于γδT细胞，描述错误的是··············································（）A、不受MHC限制B、受体缺乏多样性C、多为CD4—CD8—细胞D、主要分布在外周血15．T细胞在胸腺的发育过程中，表达前T细胞受体的细胞称为····················（）A、祖T细胞B、前T细胞C、双阳性细胞D、单阳性细胞16．T细胞在胸腺的发育过程中，进行TCR链基因重排的阶段是···················（）2A、祖T细胞B、前T细胞C、双阳性细胞D、单阳性细胞17．T细胞在胸腺的发育过程中，进行TCR链基因重排的阶段是···················（）A、祖T细胞B、前T细胞C、双阳性细胞D、单阳性细胞18．下列主要辅助B细胞活化，促进B细胞的增殖、分化和抗体生成的T细胞是·······（）A、Th1B、Th2C、Th3D、Tr119．被称为TCR的“共受体”的分化抗原是······································（）A、CD28、CTLA-4B、CD4、CD8C、CD40、CD40LD、CD2、LFA220．下列T细胞的共刺激分子及其配体，配对错误的是····························（）A、CD28与CD80/CD86B、CTLA-4与CD80/CD86C、CD40与CD40LD、LFA-1与LFA-221．下列不属于主要介导黏附作用的T细胞表面分子是···························（）A、CD2B、ICAM-1C、LFA-1D、CTLA-422．下列不能通过FasL/Fas途径诱导靶细胞凋亡的细胞是·························（）A、效应CTLB、NKC、NKTD、Th223．下列细胞间相互作用无MHC限制性的是····································（）A、Th与B细胞B、Th与DC细胞C、NKT与靶细胞D、CTL与肿瘤细胞24．活化后能促进T细胞活化信号的转导，与CD4/CD8胞浆区相联的PTK是·········（）A、p56LckB、p59FynC、ZAP-70D、PLC-γ25．T细胞在胸腺的发育过程中，进行TCR链基因重排的阶段是···················（）A、祖T细胞B、前T细胞C、双阳性细胞D、单阳性细胞26．T细胞在胸腺的发育过程中，最早表达TCR的阶段是··························（）A、祖T细胞B、前T细胞C、双阳性细胞D、单阳性细胞27．T细胞在胸腺的发育中，经阳性选择后······································（）A、祖T细胞发育成前T细胞B、前T细胞发育为双阳性细胞C、双阳性细胞发育成单阳性细胞D、单阳性细胞发育为成熟T细胞28．T细胞在胸腺的发育中，经阴性选择后······································（）A、祖T细胞发育为前T细胞B、前T细胞发育为成双阳性细胞C、双阳性细胞发育为单阳性细胞D、单阳性细胞发育为成熟T细胞29．阳性选择的意义是·······················································（）A、DP分化为SPB、获得MHC限制性C、清除自身反应性T细胞D、A＋B30．关于阳性选择，下列表述错误的是·········································（）A、发生在胸腺的皮质3B、被TCR识别自身抗原肽-自身MHCⅠ/Ⅱ分子复合物位于树突状细胞表面C、与自身抗原肽-自身MHCⅠ/Ⅱ分子复合物适当亲和力结合的DP才能发育成SPD、阳性选择后的SP具有MHC限制性31．关于阴性选择，下列表述错误的是··········································（）A、发生在胸腺的皮质髓质交界处及髓质区B、被TCR识别自身抗原肽-自身MHCⅠ/Ⅱ分子复合物位于树突状细胞表面C、与自身抗原肽-自身MHCⅠ/Ⅱ分子复合物适当亲和力结合的DP才能发育成SPD、经历阴性选择后的T细胞具有自身耐受性32．关于TCR基因重排，下列表述错误的是·····································（）A、TCR链V区基因由V、D、J基因片段重排而成B、TCR链V区由V、J基因片段重排而成C、链基因重排顺序为：D-J连接V-DJ连接D、链基因重排成功的细胞表面表达TCR33．前T细胞受体，下列表述错误的是··········································（）A、由TCR链与pT组成B、识别抗原肽-MHC分子复合物能力弱C、表达在前T细胞阶段D、能抑制同源染色体上TCR链基因重排34．关于TCR共受体，下列表述错误的是·······································（）A、CD4与MHCⅡ类分子结合B、CD8与MHCⅠ类分子结合C、共受体分子的胞浆区具有ITAMD、参与T细胞活化第一信号的转导35．关于CD4＋T细胞，下列表述错误的是·······································（）A、在与APC的相互作用中，受MHCⅡ类分子限制B、其TCR识别的抗原肽由8～10氨基酸残基组成C、活化后，分化为Th1、Th2、Th3等效应细胞D、占T细胞60%～65%36．关于CD8＋T细胞，下列表述错误的是·······································（）A、在与靶细胞的相互作用中，受MHCⅠ类分子限制B、活化后，分化为CTLC、其TCR识别的抗原肽由8～10氨基酸残基组成D、占T细胞60%～65%37．诱导Th0分化为Th1的细胞因子是·········································（）A、IL12、IFN-B、IL4、IL10、TGFC、IL4D、IL6、TGF38．诱导Th0分化为Th2的细胞因子是·········································（）A、IL12、IFN-B、IL4、IL10、TGFC、IL4D、IL6、TGF39．诱导Th0分化为Th3的细胞因子是·········································（）A、IL12、IFN-B、IL4、IL10、TGFC、IL4D、IL6、TGF40．诱导Th0分化为Th17的细胞因子是········································（）4A、IL12、IFN-B、IL4、IL10、TGFC、IL4D、IL6、TGF41．Th3主要产生的细胞因子是···············································（）A、IL2、TNF、IFN-B、IL4、IL5、IL10、IL13C、IL17、IL21、IL22、IL26、TNFD、TGF42．Th17产生的细胞因子有··················································（）A、IL2、TNF、IFN-B、IL4、IL5、IL10、IL13C、IL17、IL21、IL22、IL26、TNFD、TGF43．Th1主要产生的细胞因子主要是···········································（）A、IL2、TNF、IFN-B、IL4、IL5、IL10、IL13C、IL17、IL21、IL22、IL26、TNFD、TGF44．Th2主要产生的细胞因子有···············································（）A、IL2、TNF、IFN-B、IL4、IL5、IL10、IL13C、IL17、IL21、IL22、IL26、TNFD、TGF45．Tfh产生的、在B细胞分化为浆细胞产生抗体和Ig类别转换中发挥重要作用的细胞因子是······································································（）A、IL21B、IFN-C、IL17D、TGF46．Th1产生的对Th2具有抑制作用的细胞因子是·······························（）A、TNFB、IFN-C、IL4D、TGF47．Th2产生的对Th1具有抑制作用的细胞因子是·······························（）A、TNFB、IFN-C、IL4D、TGF二、名词解释TCR-CD3复合物阳性选择阴性选择前T细胞受体三、填空题1．TCR-CD3复合物中，TCR的作用是特异性识别，CD3分子的作用是转导。2．