灵芝预处理对脑缺血再灌注损伤海马神经元的保护

SICENCE新闻发布作者：张旺信稿号：NRR_207_14灵芝预处理对脑缺血再灌注损伤海马神经元的保护药理研究发现，传统中药灵芝具有较强的抗氧化及抗炎作用。为此，来自中国山东省立医院杜怡峰教授所带领的团队设计了预先以灵芝水溶液灌胃治疗大鼠脑缺血再灌注损伤的实验方案，发现灵芝预处理可减少脑缺血再灌注损伤大鼠海马神经元缺失，降低海马和血清中丙二醛水平，提升超氧化物歧化酶水平，同时降低海马组织中炎症相关因子肿瘤坏死因子α和白细胞介素8的表达。表明灵芝通过抗氧化和抗炎作用可对脑缺血再灌注损伤大鼠海马神经元产生保护作用。相关文献发表于《中国神经再生研究（英文版）》杂志2014年8月第15期。免疫组化染色显示，脑缺血再灌注损伤大鼠经3d灵芝水溶液灌胃后，海马组织中肿瘤坏死因子α的表达明显降低Article:Neuroprotectiveeffectofpretreatmentwithganodermalucidumincerebralischemia/reperfusioninjuryinrathippocampus,byWangxinZhang1,2,QiulingZhang2,WenDeng2,YaluLi2,GuoqingXing2,XianjunShi2,YifengDu1(1DepartmentofNeurology,ShandongProvincialHospital,ShandongUniversity,Jinan,ShandongProvince,China;2DepartmentofMedicalPsychology,TaishanMedicalUniversity,Taian,ShandongProvince,China)ZhangWX,ZhangQL,DengW,LiYL,XingGQ,ShiXJ,DuYF.Neuroprotectiveeffectofpretreatmentwithganodermalucidumincerebralischemia/reperfusioninjuryinrathippocampus.NeuralRegenRes.2014;9(15):1446-1452.欲获更多资讯：NeuralRegenResGanodermalucidumpretreatmentagainstcerebralI/RinjuryinthehippocampusGanodermalucidumisatraditionalChinesemedicine,whichhasbeenshowntohavebothanti-oxidativeandanti-inflammatoryeffects.Therefore,Prof.YifengDuandteamfromShandongProvincialHospitalinChinaaimedtoinvestigatetheprotectiveeffectsandmechanismsofpretreatmentwithganodermalucidum(byintragastricadministration)incerebralischemia/reperfusion(I/R)injuryinrats.Theirresultsshowedthatpretreatmentwithganodermalucidumfor3and7daysreducedneuronallossinthehippocampus,diminishedthecontentofmalondialdehydeinthehippocampusandserum,decreasedthelevelsoftumornecrosisfactor-αandinterleukin-8inthehippocampus,andincreasedtheactivityofsuperoxidedismutaseinthehippocampusandserum.TheseresultswhichhavebeenpublishedintheNeuralRegenerationResearch(Vol.9,No.15,2014)suggestthatpretreatmentwithganodermalucidumwasprotectiveagainstcerebralischemia/reperfusioninjurythroughitsanti-oxidativeandanti-inflammatoryactions.SICENCE新闻发布作者：张旺信稿号：NRR_207_14After3-daypretreatmentwithganodermalucidum,theexpressionoftumornecrosisfactor-alphatherathippocampusdeclinedsignificantly.Article:Neuroprotectiveeffectofpretreatmentwithganodermalucidumincerebralischemia/reperfusioninjuryinrathippocampus,byWangxinZhang1,2,QiulingZhang2,WenDeng2,YaluLi2,GuoqingXing2,XianjunShi2,YifengDu1(1DepartmentofNeurology,ShandongProvincialHospital,ShandongUniversity,Jinan,ShandongProvince,China;2DepartmentofMedicalPsychology,TaishanMedicalUniversity,Taian,ShandongProvince,China)ZhangWX,ZhangQL,DengW,LiYL,XingGQ,ShiXJ,DuYF.Neuroprotectiveeffectofpretreatmentwithganodermalucidumincerebralischemia/reperfusioninjuryinrathippocampus.NeuralRegenRes.2014;9(15):1446-1452.