常见肿瘤化疗方案(2004.10.30)一、头颈部癌1、DDP+5-FuCisplatin100mg/m2i.v.(1hinf)d15-Fluorouracil1000mg/m2i.v.(continf)d1-4(5)3~4周重复,也可用于放疗前2、CBP+5-FuCarboplatin300mg/m2i.v.d15-Fluorouracil1000mg/m2i.v.(continf)d1-43~4周重复3、IPIfosfamide(异环磷酰胺)1500mg/m2i.v.(Mesna保护)d1-5Cisplatin10mg/m2i.v.(30mininf)d1-54周重复4、TIPPaclitaxel(紫杉醇)175mg/m2i.v.(3hinf)d1Ifosfamide1000mg/m2i.v.(2h,Mesna保护)d1-3Cisplatin60mg/m2i.v.d13~4周重复5、TICPaclitaxel175mg/m2i.v.(3hinf)d1Ifosfamide1000mg/m2i.v.(2h,Mesna保护)d1-3CarboplatinAUC=6i.v.(30mininf)d13~4周重复6、Docetaxel+CisplatinDocetaxel(多西紫杉醇)100mg/m2i.v.(1hinf)d1Cisplatin75mg/m2i.v.(3hinf)d13周重复7、Docetaxel+Cisplatin+5-Fluororacil(TPF)Docetaxel75mg/m2i.v.d1Cisplatin100mg/m2i.v.d15-Fluorouracil1000mg/m2i.v.(continf)d1-43周重复8、PBFCisplatin100mg/m2i.v.(1hinf)d1Bleomycin(博来霉素)15mgi.v.(bolus)d1followedby16mg/m2i.v.(continf)d1-55-Fluorouracil650mg/m2i.v.(continf)d1-54周重复9、BECCisplatin100mg/m2i.v.(1hinf)d1Epirubicin(表柔比星)70mg/m2i.v.(bolus)d1Bleomycin15mgi.v.(bolus)d1followedby12mg/m2i.v.(continf)d1-54周重复二、乳腺癌1、经典CMFCyclophosphamide(环磷酰胺)100mg/m2p.o.d1-14Methotrexate(氨甲喋呤)40mg/m2i.v.d1,85-Fluorouracil600mg/m2i.v.d1,84周重复2、改良CMFCyclophosphamide600mg/m2i.v.d1Methotrexate40mg/m2i.v.d15-Fluorouracil600mg/m2i.v.d13周重复3、ACDoxorubicin(阿霉素(化疗药物))60mg/m2i.v.d1Cyclophosphamide600mg/m2i.v.d1(,8)3周重复4、ECEpirubicin60mg/m2i.v.d1Cyclophosphamide600mg/m2i.v.d13周重复5、IEIfosfamide2000mg/m2i.v.(Mesna保护)d1,8Epirubicin30mg/m2i.v.d1,83周重复6、AC+TDoxorubicin60mg/m2i.v.d1Cyclophosphamide600mg/m2i.v.d13周重复,共4周期,然后Paclitaxel175mg/m2i.v.(3hinf)d13周重复,共4周期7、CAFCyclophosphamide500mg/m2i.v.d1Doxorubicin50mg/m2i.v.d15-Fluorouracil500mg/m2i.v.d13周重复8、CEFCyclophosphamide500mg/m2i.v.d1Epirubicin100mg/m2i.v.d15-Fluorouracil500mg/m2i.v.d13周重复9、Paclitaxel单药Paclitaxel175或200mg/m2i.v.(3hinf)d13周重复10、TADoxorubicin50mg/m2i.v.d1Paclitaxel220mg/m2i.v.(3hinf)d2(ADM后24h)3周重复11、Docetaxel单药Docetaxel75或100mg/m2i.v.(1hinf)d13周重复或者Docetaxel40mg/m2i.v.(1hinf)qw*4/6w3周重复12、Docetaxel+DoxorubicinDoxorubicin50mg/m2i.v.d1Docetaxel75mg/m2i.v.(1hinf)d13周重复13、Vinorelbine+DoxorubicinDoxorubicin40-50mg/m2i.v.d1Vinorelbine20-25mg/m2i.v.d1,83周重复14、Capecitabine单药Capecitabine2510mg/m2p.o.分两次/天,d1-143周重复15、Trastuzumab单药Trastuzumab4mg/kgi.v.(90mininf)负荷量2mg/kgi.v.(30mininf)维持量,qw三、肺癌(一)小细胞肺癌的化疗(SCLC)1、CAOCyclophosphamide1000mg/m2i.v.d1Doxorubicin(阿奇霉素)50mg/m2i.v.d1Vincristine2mgi.v.d13周重复2、CEVCyclophosphamide1000mg/m2i.v.d1Epirubicin70mg/m2i.v.d1Vincristine2mgi.v.d13周重复3、EPCisplatin80mg/m2i.v.(1hinf)d1Etoposide100mg/m2i.v.(2hinf)d1-33周重复4、ECCarboplatin300mg/m2i.v.d1Etoposide120mg/m2i.v.(2hinf)d1-34周重复5、CAECyclophosphamide1000mg/m2i.v.d1Doxorubicin40-50mg/m2i.v.d1Etoposide100-120mg/m2i.v.(1hinf)d1-33周重复6、VIPEtoposide75mg/m2i.v.d1-4Ifosfamide1200mg/m2i.v.(Mesna保护)d1-4Cisplatin20mg/m2i.v.d1-43周重复7、Topotecan单药Topotecan1.5mg/m2i.v.(30mininf)d1-53周重复8、Paclitaxel+CarboplatinPaclitaxel175mg/m2i.v.(3hinf)d1CarboplatinAUC=7i.v.(30mininf)d13周重复(二)非小细胞肺癌的化疗(NSCLC)1、Docetaxel单药Docetaxel75mg/m2i.v.(1hinf)d13周重复2、Gemcitabine单药Gemcitabine1000-1250mg/m2i.v.(30mininf)d1,8,154周重复3、Vinorelbine单药Vinorelbine30mg/m2i.v.(20mininf)d1,8,154周重复4、NPVinorelbine25mg/m2i.v.d1,8,15Cisplatin100mg/m2i.v.d14周重复5、Paclitaxel+CisplatinPaclitaxel175mg/m2i.v.(3hinf)d1Cisplatin80mg/m2i.v.(1hinf)d13周重复6、Paclitaxel+CarboplatinPaclitaxel225mg/m2i.v.(3hinf)d1CarboplatinAUC=6i.v.d13周重复7、Docetaxel+CisplatinDocetaxel75mg/m2i.v.d1Cisplatin75mg/m2i.v.d13周重复8、Gemcitabine+CisplatinGemcitabine1000mg/m2i.v.(30-60mininf)d1,8,15Cisplatin100mg/m2i.v.(30-60mininf)d14周重复9、EPCisplatin100mg/m2i.v.(30-60mininf)d1Etoposide100mg/m2i.v.(2hinf)d1-33周重复四、食管癌1、DDP+5-FuCisplatin100mg/m2i.v.(2hinf)d15-Fluorouracil1000mg/m2i.v.(continf)d1-53~4周重复2、Paclitaxel+CisptatinPaclitaxel180mg/m2i.v.(3hinf)d1Cisplatin60mg/m2i.v.(3hinf)d13周重复3、TPEPaclitaxel50mg/m2i.v.(1hinf)d1,4Cisplatin15mg/m2i.v.(1hinf)d1,4Etoposide50mg/m2i.v.(continf)d1,4QW*3,休息1周,4周一疗程4、ECFEpirubicin50mg/m2i.v.d1Cisplatin60mg/m2i.v.d15-Fluorouracil200mg/m2i.v.(continf)d1-213周重复五、胃癌1、5-Fu+CF+DDPCisplatin50mg/m2i.v.(1hinf)biwFolinicacid500mg/m2i.v.(2hinf)qw*65-Fluorouracil2000mg/m2i.v.(24hinf)qw*62、ECFEpirubicin50mg/m2i.v.d1Cisplatin60mg/m2i.v.d15-Fluorouracil200mg/m2i.v.(continf)d1-213周重复3、FAMTXMethotrexate1~1.5g/m2i.v.d15-Fluorouracil1500mg/m2i.v.d1Doxorubicin30mg/m2i.v.d15Folinicacid15mg/m2p.o.MTX后24h,q6h*124周重复4、ELFEtoposide120mg/m2i.v.(50mininf)d1-3Folinicacid300mg/m2i.v.(10mininf)d1-35-Fluorouracil500mg/m2i.v.(10mininf)d1-33~4周重复5、TCDocetaxel85mg/m2i.v.(1hinf)d1Cisplatin75mg/m2i.v.(1hinf)d13周重复六、大肠癌1、MayoClinicFolinicacid20mg/m2i.v.(bolus)d1-55-Fluorouracil425mg/m2i.v.(bolus)d1-54周重复2、deGramontFolinicacid200mg/m2i.v.(2hinf)d1-25-Fluorouracil400mg/m2i.v.(bolus)d1-2600mg/m2i.v.(22hinf)d1-22周重复3、IrinotecanMonotherapyIrinotecan125mg/m2i.v.(90mininf)qw*46周重复或者Irinotecan300-350mg/m2i.v.(90mininf)d13周重复4、FOLFORIIrinotecan125mg/m2i.v.(90mininf)qw*4Folinicacid20mg/m2i.v.(bolus)qw*45-Fluorouracil500mg/m2i.v.(bolus)qw*46周重复或者Irinotecan180mg/m2i.v.(90mininf)d1Folinicacid200mg/m2i.v.(2hinf)d1-25-Fluorourac