姜黄素预处理或后处理均可提高氧糖剥夺神经元的抗氧化能力

SICENCE新闻发布作者：巫静娴稿号：NRR_205_14姜黄素预处理或后处理均可提高氧糖剥夺神经元的抗氧化能力氧化应激损伤是加重脑缺血再灌注不可逆损伤的主要因素之一，姜黄素作为抗氧化剂可通过Nrf2依赖的Ⅱ相解毒蛋白发挥神经保护作用。来自中国重庆医科大学巫静娴博士所在团队的研究验证，姜黄素预处理或后处理，均能有效减轻氧糖剥夺大鼠大脑皮质神经元损伤，并且姜黄素还可能通过诱导Nrf2的核转位提高核内Nrf2蛋白的含量及活性，启动其下游的小分子抗氧化蛋白Trx，从而发挥抗氧化作用。作者认为，姜黄素启动内源性抗氧化通路，并激活内源性抗氧化蛋白，从而对缺血缺氧损伤大脑神经元起保护作用，其有可能成为治疗缺血性脑卒中的新策略和新思路。文章发表在《中国神经再生研究（英文版）》杂志2015年3月第3期。Article:Curcuminpretreatmentandpost-treatmentbothimprovetheantioxidativeabilityofneuronswithoxygen-glucosedeprivation,byJing-xianWu1,2,Lu-yuZhang3,Yan-linChen1,2,Shan-shanYu1,2,YongZhao1,2,JingZhao2,4(1DepartmentofPathology,ChongqingMedicalUniversity,Chongqing,China;2InstituteofNeuroscience,ChongqingMedicalUniversity,Chongqing,China;3MolecularMedicineandCancerResearchCenter,ChongqingMedicalUniversity,Chongqing,China;4DepartmentofPathophysiology,ChongqingMedicalUniversity,Chongqing,China)WuJX,ZhangLY,ChenYL,YuSS,ZhaoY,ZhaoJ(2015)Curcuminpretreatmentandpost-treatmentbothimprovetheantioxidativeabilityofneuronswithoxygen-glucosedeprivation.NeuralRegenRes10(3):481-489.欲获更多资讯：NeuralRegenResCancurcuminimprovetheantioxidativeabilityofneuronswithoxygen-glucosedeprivation?Oxidativestressinjuryisoneofmainfactorsthataggravatetheirreversiblecerebralischemia/reperfusioninjury.Curcumin,asanantioxidant,exhibitsneuroprotectiveeffectsthroughtheNrf2pathway.Dr.Jing-xianWu,ChongqingMedicalUniversity,Chinaandhiscolleaguesrecentlyconfirmedthatcurcuminpretreatmentandpost-treatmentbothalleviatedratcerebralcorticalneuroninjuryafteroxygen-glucosedeprivation;inaddition,curcumincouldincreasenuclearNrf2proteinlevelandactivitybyincludingnuclearaccumulationofNrf2andactivatethedownstreamsmallmoleculeTrx.Jing-xianWuetal.consideredthatcurcuminshowsneuroprotectiveeffectsoncerebralneuronsfollowingischemia/reperfusioninjurythroughstartingendogenousanti-oxidativepathwayandactivatingendogenousanti-oxidativeprotein.TheseSICENCE新闻发布作者：巫静娴稿号：NRR_205_14findingsprovidenewstrategiesandthoughtsforthetreatmentofischemicstroke.Article:Curcuminpretreatmentandpost-treatmentbothimprovetheantioxidativeabilityofneuronswithoxygen-glucosedeprivation,byJing-xianWu1,2,Lu-yuZhang3,Yan-linChen1,2,Shan-shanYu1,2,YongZhao1,2,JingZhao2,4(1DepartmentofPathology,ChongqingMedicalUniversity,Chongqing,China;2InstituteofNeuroscience,ChongqingMedicalUniversity,Chongqing,China;3MolecularMedicineandCancerResearchCenter,ChongqingMedicalUniversity,Chongqing,China;4DepartmentofPathophysiology,ChongqingMedicalUniversity,Chongqing,China)WuJX,ZhangLY,ChenYL,YuSS,ZhaoY,ZhaoJ(2015)Curcuminpretreatmentandpost-treatmentbothimprovetheantioxidativeabilityofneuronswithoxygen-glucosedeprivation.NeuralRegenRes10(3):481-489.