孤束核在艾灸保护胃粘膜损伤中的作用

SICENCE新闻发布作者：彭亮稿号：NRR_14_14孤束核在艾灸保护胃粘膜损伤中的作用目前在灸疗保护胃粘膜机制领域，同类多项研究已证明艾灸对胃粘膜的保护作用确与艾灸上调热休克蛋白70表达有关，然而尚未见到在灸疗保护胃粘膜机制的神经通路相关机制分析的报道。湖南中医药大学针灸推拿学院彭亮博士所在课题组进行的一项研究证实，艾灸足三里穴（ST36）预处理对胃粘膜损伤有明显保护作用，孤束核损毁可明显抑制其保护效应，由此推断孤束核是艾灸减轻胃粘膜损伤的重要中枢神经信息调节部位。作者认为，文章结果对探明艾灸作用神经传导途径有重要的指导意义，同时对艾灸治病机制的研究提供了重要的理论依据。文章发表在《中国神经再生研究（英文版）》杂志2014年1月第2期。苏木精伊红染色显示，大鼠孤束核严重受损，图中切片中箭头所指示核团损坏灶，并有神经传导簇生成，系损害后引起Article:Roleofthenucleustractussolitariiintheprotectionofpre-moxibustionongastricmucosallesions,byLiangPeng,MiLiu,XiaorongChang,ZhouYang,ShouxiangYi,JieYan,YanPeng(CollegeofAcupunctureandTuina,HunanUniversityofChineseMedicine,Changsha410007,HunanProvince,China)PengL,LiuM,ChangXR,YangZ,YiSX,YanJ,PengY.Roleofthenucleustractussolitariiintheprotectionofpre-moxibustionongastricmucosallesions.NeuralRegenRes.2014;9(2):198-204.欲获更多资讯：NeuralRegenRes.NTS’sroleintheprotectionofpre-moxibustionongastricmucosallesionsMoxibustionmayhaveprotectiveeffectsonthestomachmucousmembraneagainststressgastriculcer.Thepotentialmechanismofmoxibustionmaybemediatedbytransforminggrowthfactor-α,gastricmucosacellproliferation,inhibitionofapoptosis,andtheexpressionofheatshockprotein-70.Previousstudieshaveshownthatsomaticsensationbyacupunctureandvisceralnociceptivestimulationcanconvergeinthenucleustractussolitarii(NTS)whereneuronsintegratesignalsimpactingonthefunctionoforgans.ToexploretheroleoftheNTSintheprotectivemechanismofpre-moxibustionongastricmucosa,Dr.LiangPengandco-workersfromCollegeofAcupunctureandTuina,HunanUniversityofChineseMedicineinChinapointedoutthatmoxibustionpretreatmentattheZusanlipointisprotectiveagainstacutegastricmucosainjury,andNTSdamageinhibitstheseresponses.Therefore,theNTSmaybeanimportantareaforSICENCE新闻发布作者：彭亮稿号：NRR_14_14regulatingthesignaltransductionoftheprotectiveeffectofpre-moxibustionongastricmucosa.TherelevantpaperhasbeenpublishedintheNeuralRegenerationResearch(Vol.9,No.2,2014).Nucleustractussolitariidamageisshownbyhematoxylin-eosinstaining.Arrowsindicatenucleusdamage(blockofnerveconduction,causedbytheinduceddamage).Article:Roleofthenucleustractussolitariiintheprotectionofpre-moxibustionongastricmucosallesions,byLiangPeng,MiLiu,XiaorongChang,ZhouYang,ShouxiangYi,JieYan,YanPeng(CollegeofAcupunctureandTuina,HunanUniversityofChineseMedicine,Changsha410007,HunanProvince,China)PengL,LiuM,ChangXR,YangZ,YiSX,YanJ,PengY.Roleofthenucleustractussolitariiintheprotectionofpre-moxibustionongastricmucosallesions.NeuralRegenRes.2014;9(2):198-204.