基于体素形态学揭示隐匿大血管病变影响2型糖尿病患者的脑微结构

SCIENCE新闻发布作者：王春霞稿号：NRR-89-14基于体素形态学揭示隐匿大血管病变影响2型糖尿病患者的脑微结构2型糖尿病患者容易出现MRI影像上较明显的与认知功能障碍相关的脑萎缩，而在这些明显的萎缩出现之前，早期检出患者脑结构的细微变化，将助于及时干预并防止明显脑萎缩及相关认知功能障碍的出现。中国河北医科大学第二医院刘怀军所带领的团队，通过使用基于体素的形态学分析法，可以检测出2型糖尿病患者主要位于右颞叶和左枕叶脑早期细微的结构异常，并发现这些异常与早期隐匿的大血管病变及慢性高血糖状态密切相关。因此，作者认为，如果能够早期提供这些信息，使医生能够早期干预隐匿的大血管病变及控制血糖，可能阻止和延缓脑萎缩及与之相关的认知功能下降。相关文献发表于《中国神经再生研究（英文版）》杂志2014年8月第16期。全脑范围基于体素的形态学分析显示，2型糖尿病患者右颞上回、左枕下回及右颞下回出现局部灰质丢失Article:Brainstructuralchangesandtheircorrelationwithvasculardiseaseintype2diabetesmellituspatients:avoxel-basedmorphometricstudy,byChunxiaWang1,KailiangFu1,HuaijunLiu1,FeiXing1,SongyunZhang2(1DepartmentofMedicalImaging,theSecondHospitalofHebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China;2DepartmentofEndocrinology,theSecondHospitalofHebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China)WangCX,FuKL,LiuHJ,XingF,ZhangSY.Brainstructuralchangesandtheircorrelationwithvasculardiseaseintype2diabetesmellituspatients:avoxel-basedmorphometricstudy.NeuralRegenRes.2014;9(16):1548-1556.欲获更多资讯：NeuralRegenResSCIENCE新闻发布作者：王春霞稿号：NRR-89-14BrainstructurerelatedwithmacroangiopathyinT2DMpatients:avoxel-morphometricstudyPatientswithtype2diabetesmellitus(T2DM)mayshowbrainatrophywithcognitivedeclineinMRI.However,earlydetectionofmicrostructuralchangesinthebraincanhelptopreventagainstbrainatrophyandcognitivedysfunction.AresearchteamledbyHuaijunLiuattheSecondHospitalofHebeiMedicalUniversityinChinausingvoxel-basedmorphometrydetecteddifferencesinvolumesofgrayandwhitematterintherighttemporallobeintheabsenceofobviousdecreaseintotalgrayandwhitemattervolumebetweenT2DMpatientsandcontrols.Theseregionalvolumechangeswerecorrelatedwithmacrovasculardiseaseandchronichyperglycemia.Researchersconsiderthattosupporttheseinformationasearlyaspossiblecanalertthephysiciantomacrovasculardiseasesthatcanbetreatedbyearlyinterventionandbloodglucosecontroltherebytopreventanddelaybrainatrophyandrelevantcognitivedecline.TherelevantarticlehasbeenpublishedintheNeuralRegenerationResearch(Vol.9,No.16,2014).Theregionsofgraymatterlossintype2diabetesmellitusaretherightsuperiortemporalgyrus,leftoccipitalgyrusandrightinferiortemporalgyrus.Article:Brainstructuralchangesandtheircorrelationwithvasculardiseaseintype2diabetesmellituspatients:avoxel-basedmorphometricstudy,byChunxiaWang1,KailiangFu1,HuaijunLiu1,FeiXing1,SongyunZhang2(1DepartmentofMedicalImaging,theSecondHospitalofHebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China;2DepartmentofEndocrinology,theSecondHospitalofHebeiMedicalUniversity,Shijiazhuang,HebeiProvince,China)WangCX,FuKL,LiuHJ,XingF,ZhangSY.Brainstructuralchangesandtheircorrelationwithvasculardiseaseintype2diabetesmellituspatients:avoxel-basedmorphometricstudy.NeuralRegenRes.2014;9(16):1548-1556.