§1前言§1前言——生物医学统计及数据分析生物医学计及

AppliedMathematicsinBiomedicineAppliedMathematicsinBiomedicineAppliedMathematicsinBiomedicineAppliedMathematicsinBiomedicine1111————hiihiiZhuHuaiqiuBME@[e-mail],.2003,,20032.G.P.Quinn,M.J.Keough,,,,2003,,20033.20064.200212121.21.2zBiomedicine——humanmedicine,veterinarymedicine,odontologyandfundamentalbiosciencessuchasbiochemistry,chemistrybiologyhistologygeneticsembryologyanatomychemistry,biology,histology,genetics,embryology,anatomy,physiology,pathology,biomedicalengineering,zoology,botanicsandmicrobiology.gy——Itiswiththetheory,knowledgeandresearchandrenderspossiblenewdrugsandadeeper,molecularunderstandingofthemechanismsunderlyingdisease,andthuslaysthefoundationofallmedicalapplicationdiagnosisandtreatmentfoundationofallmedicalapplication,diagnosisandtreatment.SystemsbiologyLifesciencesLifesciencesMedicineMedicineMathematics/StatisticsMathematics/StatisticsPhysicalsciencesPhysicalsciencesComputationalbiologySyntheticbiologyEngineeringsciencesEngineeringsciencesbiologyBiomedicalInformationTechnologiesInformationTechnologiesengineering……1TrendsintechnologyforbioandIT1.TrendsintechnologyforbioandITMooreCarlsonHardwaretrends(egnetworkbroadbandcapacity:100——Hardwaretrends(e.g.networkbroadbandcapacity:100timesfasteroverthelast10years)Pitfditi——Point-of-carediagnostics——Homeandpersonalizeddevices——E-healthwebinformationsystemsASeattle-basedconsortiumledbytheYagergrouphasbeenawarded$15.4millionbytheBill&MelindaGatesFoundationGrandChallengesginGlobalHealthinitiative.Theaimoftheprojectistodevelopaportabledevicethatpromisestobringthetechnologicalpowerofamodernmedicaldiagnosticslaboratorytothedevelopingmedicaldiagnosticslaboratorytothedevelopingworld.Theconsortiumco-investigatorsarePatrickStaytonoftheUniversityofWashingtonDepartmentofBioengineering,BernhardWeiglofPATH,FredBattrellofMicronics,Inc.,WA,andWaltMahoneyofNanogen,Inc.2Trendsin“wetlab”researchandvalidation2.Trendsin“wet-lab”researchandvalidation——Dedicated(geneticallymodified)model-organismsforpathologiesMajormodelorganismsofaging:yeast,roundworms,fruitfliesandmicefruitflies,andmice.Sincethebasicblocksoflifearecommontomostkiknownspecies,commonpathwaysmightbeinvolvedinagingacrossphlogen(Tienbmphylogeny(TissenbaumandGuarente,2002)——InducedPluripotentStemcells(iPScells)asadiseaseInducedPluripotentStemcells(iPScells)asadiseasemodelOrganregenerationexamplefrominducedpluripotentstemcellsOrganregenerationexamplefrominducedpluripotentstemcells3.Trendsinbiobanksanddatabasesizeandcommunitycontentorganspathwayswholecellpathwaysproteinscomplexesbiologicaldatagenes201942-46194246(1961-69)(1990-2003)HGPHGPDNA——Watson,1990,Science1982GenBankLosAlamos——1982606680,338bp10——200443,322,7567.1×1010bp——2005:Internationalsequencedatabasesexceed100GBps57005,700(Archaea)58(Bti)7782(Bacteria)7782(Eukaryo)87(Virus)1,773(Viroid)48(Phage)502(Organelle)1,764(Plasmid)739://“Dry”Experiments(Simulation)PredictionandHypothesisRetainmentModelingfromDataandHypothesisExperimentalDesignDataAnalysisAnalysisExperimentDataAnalysisGenomeTranscriptomeDataSynthesisTranscriptomeProteomeMetabolomeExperimentalDataAnalysisMetabolome……4M-model:4M-model:ModelManipulateModelManipulateMeasuredMined………………——W.Gilbert,TowardsAParadigmShiftinBiology,Nature,349(1991)99123……1.31.3Data-mining,KnowledgeDiscoveryExtractsthehiddenpatternsfromhugequantitiesofexperimentaldata,andformshypothesesasaresult.ypSimulation-basedAnalysisTestshypotheseswithinsilicoexperimentsprovidingpredictionstobeTestshypotheseswithinsilicoexperiments,providingpredictionstobetestedbyinvitroandinvivostudies.datawithoutstatisticsdatawithoutstatisticsTheDomesdayBookwastherecordofthegreatsurveyofEnglandcompletedin1086,executedforWilliamIofEngland.Thesurveywassimilartoacensusin1086,executedforWilliamIofEngland.Thesurveywassimilartoacensusbyagovernmentoftoday.Oneofthemainpurposesofthesurveywastodeterminewhoheldwhat,forthepurposeoftaxationandthejudgmentoftheassessorswasfinalwhateverthebooksaidaboutwhoheldthematerialassessorswasfinal—whateverthebooksaidaboutwhoheldthematerialwealth,orwhatitwasworth,wasthelaw,andtherewasnoappeal.12……344————————…——pH…()()()……………1.41.4StatisticsStatistics——statisticumcollegiumttit——statista——staistik————Togather,arrange,condense,coordinate,andmathematicallymanipulateobtainedfactssothatthenumericalyprelationshipsbetweenthosefactsmaybeseenclearlyandfreedfromanomaliesresultingfromchancefactors.(ImagebyMITOpenCourseWareBasedonGilbertNorma(ImagebyMITOpenCourseWare.BasedonGilbert,Norma.Statistics.W