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3:,,,3(,510275):,;;;;DFTDNA;,DNA,DNA:TheStudyofIntersectionSubjectPromotestheDevelopmentofBioinorganicChemistrySubjectMemberoftheCASJILiangnian(TheSchoolofChemistryandChemicalEngineering,TheKeyLaboratoryofGeneEngineeringofMinistryofEducation,StateKeyLaboratoryofOptoelectronicMaterialandTechnologies,SunYat2senUniversity,Guangzhou510275)Abstract:Thispaperisdividedintofollowingsevensections.Thefirstsectionreviewsthedevelop2mentofbioinorganicchemistrysubject.Thesecondsection,itindicatereviewsbysomeexamplesfromthereviewsthatthestudyofbioinorganicchemistryaimthroughoutatthemetalionsandbio2logicalligandscontrolchemicalproblemsinthecourseoflife.Thethirdsectionintroducesthepresentheateddebatefocusesintheresearchfieldofnucleicacid.Thefourthsectionreportsaseriesofnewligandsandtheirmanydifferentmetalfunctionalcoordinationcompoundsasartificialnucleases200412©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.weredesignedandsynthesizedbyauthor.Thefifthsectionisthediscussionofthestudiesonbindingmechanismandmorethantenkindsofinfluencefactorsoftheinteractionsofcoordinationcom2poundswithDNAbykinetics,theremodynamicsandDFTcalculationmethods.Thesixthsectiongivesafurtherreportofbiologicalfunctionofcoordinationcompoundsandtheirapplicationexplo2ration.Thefinalsectionisthesuggestionofsomenewdevelopmentdirectionandresearchwaysinnucleicacidfield.Theregularsamongthestructureofcoordinationcompounds,theinteractionmechanismandbiologicalfunctionaresuggestedfurtherbyauthor.ThebindingbehaviorsandbiologicalfunctionsofcoordinationcompoundsforDNAcanbemodulatedandchangedbythechangeofstructureofco2ordinationcompounds.Keywords:bioinorganicchemistry,coordinationcompounds,nucleicacid1(BioinorganicChemistry)(InorganicBiochemistry)[13],,,,,,,,,,,1970,,19R.F.GouldBioinorganicChemistry,197661620,((ICBIC)ICBIC0!),131983(ICBIC1),(ICBIC11)20037Carins,,(ISABC)J.Webb,(ISABC11)1990;(ISABC12)1992,[4];(ISABC8)20044,,200310,,,:200010,,[56],[7]:(BSCCBF)(),2004122Vol.26No.6(IOC)(BioinorganicSpec2troscopy)(DFT)(TutorialLecture),2[89],1000,,,,,(1)ÓP450();300Ó();,Ó();H2O2,Ó();H2O2Ó();Ó();ÓC();Ó();,,,,DNA25,,,,,(RH),P450(CytoP450)(R2OH),,:RH+O2+H+=CytoP450NADPHNADPR2OH+H2ONADPH[10]RH,,19995/,,,,,,,500,,,O2O2,,,O2:Hem+O2HemO2HemHemoglobin,,,ATP,,CO2HbNH2+CO2HbNHCOOH(),,40,,,(),1,()0.75!,,,,Fe()6,t2g4eg2,(),,,O2,,,,200412©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.1()t2g(),,t2g6e0,,,O2,CO,:CO(g)+HemO2(aq)O2(g)+HemCO(aq)CO,,,COK=[O2][HemCO][CO][HemO2]=210()10%HemO2HemCO,,,CO,,,O2CO,KCNCN2a3,a3,,CN2,CN2a3,,,,,CN2,,,,,Fe(por),:Fe(Por)+O2Fe(Por)(O2)(1)Fe(Por)(O2)+Fe(Por)Fe(Por)-O2-Fe(Por)(2)Fe(Por)-O2-Fe(Por)2Fe(Por)O(3)2(Fe(Por)O+2Fe(Por)2Fe(Por)-O-Fe(Por)(4),,,,(),1973J.P.Collman(picket2fence)(),,,3,DNA,DNA,,,,DNA,,,,DNA,,,,ElizabethK.Wilson[11]1997ChemicalandEngineeringNewsFlurryofNewResearch,HeatedDebateFocusesonBiomolecule,:(1)[Ru(phen)3]2+DNA?[12]DNA[Ru(phen)3]2+DNA,,CDNMR[Ru(phen)3]2+DNA2004124Vol.26No.6[Ru(phen)3]2+DNA(2)DNA?[13],:FlashQuenceDNA,DNA,Poly(G)Poly(C),DNADNA,DNA,,,DNA4[14](RSCCBF)SynthesisandBiology,DNA,,DNA,,,DNA,DNA,,DNA,MLCT,DNA,()d6,200,1H13CXCD5DNA,DNA,DFT,,CDDNA[12],(1)DNA[15];(2)DNA;(3);(4);(5);(6);(7)DNA;(8);(9)[Ru(phen)3]2+DNA;(10);(11)DNA;(12)MLCT,DNA6[16],,DNA,,:(1)DNA;(2)DNA[17];(3)DNA;(4)[18];(5)pH7,:(1)DNA,,;(2)DNA200412©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.DNA;(3)RNA,,;(4),(DNARNA);(5)DNA,DNA;(6)B2DNAZ2DNA,B2DNAZ2DNA;(7)RNA,RNA,RNA;(8),DNA,;(9)DNADNA[1]..:,1988,9[2],.,:,2002,4[3],,..:,()2001,9[4]..,2000,(3):60[5]..:,2003,10[6]..:,2002,10[7],..,2004,16(4):660666[8]..(;P972P119).:,2001,3[9],,..,2000,12(2):120126[10]..24.:,2004,P10[11]WilsonE.K..Flurryofnewresearch,heateddebatefocusesonbiomolecule.Insulatororwire?ChemicalandEngineeringNews,1997,(75):3339[12],,.DNA.,2001,(B)31(3):193204[13]YaXiong,Liang2nianJi.DNA2bindingandDNA2mediatedlumi2nescencequenchingofRu()polypyridinecomplexes.Coord.Chem.Rev.,1999,(186):711733[14]Liang2nianJi,Xiao2huaZou,Jin2gangLiu.Shapeandenantiose2lectiveinteractionofRu()/Co()polypyridylcomplexeswithDNA.CoordChem.Rev.,2001,(2162217):513536[15]Jin2gangLiu,Liang2nianJietal.Enantiomericruthenium()complexesbindingtoDNA:Bindingmodesandenantioselectivity.J.Biol.Inorg.Chem.,2000,5(1):119128[16],,.DNA.,2001,46(6):451460[17]Xiao2huaZou,Liang2nianJietal.ThedesignofnewmolecularLightSwitchesforDNA.J.Biol.Inorg.Chem.,2001,6(2):143150[18],..,2002,14(4):296304(JILiangnian,1934-),,,,,400400,310;4;9(:)2004126Vol.26No.6