利尿剂甲基衍生物质谱行为的研究α

a(100029)(100038)GCöMS,GCöMSöMS,,:GCöMSGCöMSöMS,,,GCöMS,GC,,[1]GCöMS,,,GCöMSöMS,,[]2B22[3],,1111Bumetanide,Piretanide,chlorthalidoneBendroflumethiazideSigma;,,;;,,4002112GCöMS:FisonsGC8000öMD800,HP21(18m0.2mm21Vol.211JOURNALOFCHINESEMASSSPECTROMETRYSOCIETYNo.1a19992082020133Lm),019ö(180);;280,290;200,70eV:10020ömin280,5min,10ömin290,5,10ömin300,2GCöMSöMS:GCHewlettPackardHP5890Êplus,MSöMSFinniganTSQ27000HP21(17m012mm0111Lm);,019ö(180);118;280,280EI,180,70eV,13kV,400LA,1200V0178Hz;450a.m.u.,118210mTorr,-5-30V:180,313ö231,30ö310,2113,,100Ll,100Ll50mg603,,GCöMS,,,GCöMSöMS2211GCöMSBendroflumethiazideBumetanideChlorthalidonePiretanide10320001,,212GCöMSöMS21211Bendroflumethiazide(BF)477,,,möz386möz278,möz386,,BF22BF21212Bumetanide(BM),,108möz298,möz406möz363,möz318,,BM,CH3-N=CH2,,SO2BM321213Chlorthalidone(CT),möz363,möz176,möz255möz363möz287,möz287möz351CT,BMCT41313BM4CT21214Piretanide(PT),möz295möz404,möz296möz405,,109HSO2N(CH3)2PTBM,,23200055PT21321311,GCöMS,,,;,;,,,21312GCöMSöMS,,,GCöMS1,,,.GCöMS,,1996,17(4):732XinLiu,MoutianWuetal.ApplicationofTSQ27000inDopingControlAnalysis,16thCologneWorkshoponDopeAnalysis,19983KairongCui,MoutianWuetal.StudyontheMetabolitesofBromantaneinUrineUsingGCöMSandGCöTandemMSöMS,16thCologneWorkshoponDopeAnalysis,1998331StudyontheFragmentationPathwaysofMethylatedDerivativesofDiureticsWangXiaobing,WuMoutian,ZhuShaotang,QinYang(NationalInstituteofSportsMedicine,Beijing100029,China)WangConghui(TheInstituteofForensicScience,Beijing100038,China)Received1999208202AbstractAsweknowthatGCöMShasbeenwidelyappliedtodopingcontrolanalysis,butitisdifficulttointerpretthemassspectra.ThispaperintroducedtheapplicationofGCöMSöMStodiureticsanalysis.ThefragmentationpathwayswerestudiedbyMSöMSinparentmode,andtheresultsindicatedthemechanismthroughwhichthecharacteristicionsformed.KeyWords:diuretics,dopingcontrolanalysis,GCöMS,GCöMSöMS432000