数控车床作业2

1302007422ChinMedBiotechnol,April2007,Vol.2,No.2··bioactivepeptide[1]1902BaylissStartling[2]fastatombombardmentmassspectromentrytwodimensionnuclearmagneticresonance40.86%[3]McCubbin[4]nostocsp.cryptophycin711multi-drugresistanceMDR[5]MDR1scytonemataceaescytonemamirabileBY-8-13824KBIC500.0110mg/L[6]Edwards[7]lyngbyamajuscula2microcolinsABP388IC500.4mg/LToddGerwick[8]1994debromoaplysiatoxinP38867%1.5g/LhormidiumenteromorphoidessargassumhornerisargassumtortilesargassumhemiphyllumcodiumpugniformisCodiumfragileporphyrayezoensis26.20%[9]Schirmer[10]discodermiakiiensisdiscokiolidesABCDP388IC502.6mg/LB16IC501.6mg/LlewisIC501.2mg/LLu-99IC500.7mg/LHT-29IC501.2mg/LHepG2IC500.57mg/LDNAJaspisjapamideIC501µg/mlIC500.32µg/ml[11]Bernay[12]1bioactivepeptidesofoyster1BPO-1BPO-1[13]sharkhepaticactivepeptideSHAPSHAPAAPBALB/cAAP200mg/kg36h11.98%±0.47%3mg/kgSHAP3.24%±1.62%ACBP[14-17][e-mail]2007-03-012007422ChinMedBiotechnol,April2007,Vol.2,No.21318000ACBPACBPMGC-803BGC-823GBC-SDnm231VIP1970SaidMuttVIP283323-VIPVIP[18]VIP[19]22[20]269814[21]2674121960crotonmonguemonguin[22]6[23]S180S37LewisP388IL-1IFNTNF-α[24-25]Huber[26]reactiveoxygenintermediate[27]rapeseedpeptideS180IgM[28-29]IL-2IL-2[30][1]WangZC,AnYH.Researchprogressofbiopeptides.HenanMedRes,2004,13(4):353-356.(inChinese),..,2004,13(4):353-356.[2]ZhaoL,SuW,HuHG,etal.Researchprogressofcollagenpeptides.FoodSci,2005,26(9):578-581.(inChinese)1322007422ChinMedBiotechnol,April2007,Vol.2,No.2,,,..,2005,26(9):578-581.[3]SimmonsTL,AndrianasoloE,McPhailK,etal.Marinenaturalproductsasanticancerdrugs.MolCancerTher,2005,4(2):333-342.[4]McCubbinJA,MaddesML,LautensM.Totalsynthesisofcryptophycinanaloguesviaascaffoldapproach.OrgLett,2006,8(14):2993-2996.[5]StevensonJP,SunW,GallagherM,etal,PhaseItrialofthecryptophycinanalogueLY355703administeredasanintravenousinfusiononaday1and8scheduleevery21days.CliCancerRes,2002,8(8):2524-2529.[6]CarmeliS,MooreRE,PattersonGM.Tolytoxinandnewscytophycinsfromthreespeciesofscytonema.JNatProd,1990,53(6):1533-1542.[7]EdwardsDJ,MarquezBL,NogleLM,etal.Structureandbiosynthesisofthejamaicamides,newmixedpolyketide-peptideneurotoxinsfromthemarinecyanobacteriumlyngbtamajuscula.ChemBiol,2004,11(6):817-833.[8]ToddJS,GerwickWH.Isolationofacycliccarbonate,agamma-butyrolactone,andanewindolederivativefromthemarinecyanobacteriumLyngbyamajuscula.JNatProd,1995,58(4):586-589.[9]SongJM.21thcenturydevelopingstrategyofmarinenaturalactiveproductsinChina.MarineSci,2001,25(4):50-53.(inChinese).21.,2001,25(4):50-53.[10]SchirmerA,GadkariR,ReevesCD,etal.MetagenomicanalysisrevealsdiversepolyketidesynthasegeneclustersinmicroorganismsassociatedwithmarinespongeDiscodermiadissolute.ApplEnvironMicrobiol,2005,71(8):4840-4849.[11]OikiS,MuramatsuI,MatsunagaS,etal.Achannel-formingpeptidetoxin:polytheonamidefrommarinesponge(Theonellaswinhoei).NipponYakurigakuZasshi,1997,110Suppl1:195P-198P.[12]BernayB,Baudy-Floc’hM,ZanuttiniB,etal.OvarianandspermregulatorypeptidesregulateovurationintheoysterCrassostreagigas.MolReprodDev,2006,73(5):607-616.[13]LüZB,LiQ,GuoY,etal.Immunomodulativeandantiapoptoticeffectofsharkhepaticactivepeptide.ChinJPharmToxico,2004,18(6):433-438.(inChinese),,,..,2004,18(6):433-438.[14]HouJF,YanMR,YanXH,etal.Effectofanti-cancerbioactivepeptideonleukemiamice.ActaAcaMedNeimongol,2004,5(1):12-15.(inChinese),,,..,2004,5(1):12-15.[15]YanMR,SuXL,LiuQP.Effectofanti-gastriccancerbiologicalpeptideonlacticdehydrogenaseisoenzyme.ChinJCancerPrevTreat,2002,9(4):382-383.(inChinese),,.LDH.,2002,9(4):382-383.[16]LiuQP,SuXL,YanMR,etal.Effectofanti-GCBAPonesteraselsoenzymesmetabolismingastriccancer-bearingnudemice.ChinJCancerBiother,1997,4(1):61-63.(inChinese),,,..,1997,4(1):61-63.[17]SuXL,KeY.Theexperimentalresearchonanti-gastriccanceractivepeptide.IntJModCancerTher,1999,2(2):26-27.[18]XuHY.Regulatoryeffectsofvasoactiveintestinalpeptide.ForeignMedSci·SectionImmunol,2002,25(2):73-76.(inChinese)..,2002,25(2):73-76.[19]ZhengYF,WangZP,XuYY.Advancesonseveralimmunologiccompetencepeptides.FeedInd,2006,27(5):7-9.(inChinese),,..,2006,27(5):7-9.[20]GuoQQ,ZhangLW.Theresearchofactivepeptideinfood.FoodMachinery,1999,13(6):12-14.(inChinese),..,1999,13(6):12-14.[21]ZhangY.Amphibianskinsecretionsandbio-adaptivesignificance:implicationsfrombombinamaximaskinsecretionproteome.ZoolRes,2006,27(1):101-112.(inChinese)..,2006,27(1):101-112.[22]RalisonC,CreppyEE,BoulangerY,etal.PurificationandcharacterizationofatoxininhibitingproteinsynthesisfromCrotonmongue,aMadagascarEuphorbiaceae.Biochimie,1986,68(10-11):1225-1230.[23]GeYQ,YuJY,SongYW,etal.Researchadvanceinbiologicallyactivepeptides.ChinJBiochemPharm,1998,19(6):404-406.(inChinese),,,..,1998,19(6):404-406.[24]KongJL,DuXB,FanCX,etal.PurificationandprimarystructuredeterminationofanovelpolypeptidefrommistletoeViscumcoloratum.ChinBiotechnol,2005,25(10):34-38.(inChinese),,,.B6.,2005,25(10):34-38.[25]KongJL,DuXB,FanCX,etal.Determinationofprimarystructureofanovelpeptidefrommistletoeanditsantitumoractivity.ActaPharmSinica,2004,39(10):813-817.