拾、生物及医农学研究之推动

13530,7934153124-361029921731094-374-361.2.3.4.HSC705.6.7.8.9.D10.11.12.1314.1364-381,892144,5404-391859.8%4-378536324,9591811570301563929168633421,6321651394251353898578737025,9362101501251704039598845627,3822171391351904871,0518931230,79317310924381574919924-388551537,1382562430124459568654634,8122682601174631,0098757442,4793043054245331,1708863755,05046528630155681,3648962954,03243125862126081,3711374-390.389651,2690.324-39851,33080,27944755201323419652,437861,41485,47044764511483529692,562871,583103,39555671471014261,0752,879881,645119,56756368171684441,0092,836891,892144,540639760171385611,2693,4381381391.10911,843108.64-4010%1718173510XDHSC70JAK-STATDHEASHSC7024P3RNA4-40851157,91086956,030871117,84788897,8928910911,8431402.8,22494.54-41Tp53(Ras)80%(myxininaes)4-41851016,178861267,758871257,857881058,23089878,224141(EGFR)(ED)EGFR3.11610,72692.54-424-428514610,762861137,8448713410,2318811911,2608911610,726142ISSR(Intersimplesequencerepeat)DNADNAITS(internaltranscribedspacerregion)DNAC-19gibberellinDNAGGTTTAGcysteinecathepsinLBWI12WUN1RNARNA143ATPaseRNARNARNA(phytase)pH1.3,634P5CROATABAPaclobutrazol15°C25°C10°C-80°Cm-RNARAPD1441~2γGUS0.7KbPCRGUSDNAcDNAIndole-3-butyricacido-o-PinkAristocratWhiteAristocratNH4NO3QTLmappingQTLgene-for-gene2.1,6281453.2,762gp64helpolh146Esteyavermicola199(REP-PCR)(Pythiumspp.)(hairpin)RNA(SigmaFactor)rpoDSigmaFactor4.3,988pHSPRSsS1147EcoliDH5αpUC19PseudomonasluteoldE.coliClpYQ5.4,8360.2-0.63cm3041J1081513900µε390kgf/2PE-NCsemi-IPN5cadinaneGulph11.5×10-4~1.85×10-4cm/s8.6×10-4cm/s18×10-4cm/s148162ha734ha6.4,463arntcDNAMTSNgeneCEPCRWSSV7.3,213EEPA14911.5L4,279ELPSELISAEMRT-PCRsigmaNSHSP90HSP90HCMHCM8.6,9911.48×1061.18×1064.92×104daltons(CFW)PFGEX3S3N3DNA9.1503,9755.8868810m×10m40320%51511.7,0574-43(NO)(glutamate)NOL-dopanicotinamide2.4-4385442,63886522,86987543,53588725,24589817,0571521261,1054-44GDC3.1248,1684-45CAGCAG22222.0BC2.64-4585342,02186562,69287644,34588946,321891248,1684-4485302,07786423,11787664,71888736,1188912611,05415347%PCR13%(HPV)1647%HPV18HPVp5313%4%TNM-6-2.41.5EANO25°CG1(SF-36)154DALY(disability-adjustedlifeyear)4.4-46EBBDT5.5354-47SCID4-47851385086148658713912881093789105354-4685634,22786664,10987875,81288514,20989595,2561556.4,01818%37%47%4-48AB71AG6PDAlpha17.2,9924-494-4885312,03286421,96787512,16388553,70489564,018156A(GABAA)(Grave’sdisease)8.2,2514-50BP27P53bcl-2CCAMT9.6,4434-514-5085301,75586281,46887291,73788261,89389322,2514-5185422,67986422,32787583,86288675,56089806,4434-4985341,97286311,64787382,04988352,36889452,992157YC-1sGCPKCintegrin10.2,7084-52ESeCβ-B6ADD-1/SREBP-1CEPAADD-1/4-5285251,42686351,27587391,74188372,23689392,708158SREBP-1CEcytochromeP-450IIBE1L-24.5LDLIL-1βTNF-αPGE2B6-I11.4-53N7-Adeninesecoribonucleoside4-∆2EC500.5µg/mlN-[2-(5-Nitrothiazolyl)]-cantharidinimideHep-3B(IC500.4µM)SK-Hep-1(IC501.25µM)TussilagolidesA-JPlakortissim-plexFuranCembranePVerapamil(Sodiumdeoxycholate)(Sodiumcaprate)EpirubicinCremophorELNalbuphineVancomycinPLLA/PEGPMMA(rAAV)HepG24-5385523,02286542,76187663,97688896,072891047,105159(120-140%)(150-170%)GlutamateAspartatePGE2(JusticidinA)β-amyloidβ-amyloid(C-18)[fattyacid2-(2-naphthoxy)ethylester]5.6nM12.3,8144-544-5485614,85686563,24487654,33288594,46589553,81416013.2,9494-5514.4,0454-564-5685411,91886512,15287682,96688783,35089814,0454-5585271,40386371,73287411,99288372,02789562,94916115.10757%3,8634-57erbB2EGFRP53β-catenin16.1,3624-584-5785341,71386532,68287583,18888613,26489613,863162Serotonin518MPIDNA5HTTLPRhalo-peridolrisperidone50%22g1117.2,1304-5918.1269,1954-5985301,46886241,04787261,21488341,21489382,1314-58851261886127998714807881895089241,3621634-601,74025-30N19.2,8324-61NTH3T3-L1(differentialdisplay)mRNAPPARγ4-6185271,50286311,93387301,85688392,43889412,8324-6085573,08886552,69287694,19188856,400891269,195164SF-1FasFliceBcl-2B12MTHFRremethylationAT1AT1anti-Thy1fractalklinemesangialcellsfractalklinemRNATNF-αIFN-γTGF-β1CTGFLLC-PK1NRK-49FCTGF20.3,3964-62(Cytokine)TB19EB4-6285472,53886452,61787342,47688423,07389483,39616521.5,0904-63B(HBV)E4BP4HBVE4BP4αHBV(IL-4)HBVDNAHLA-peptideteramericcom-plexLamivudineALTHBVgenotypeC(HCV)HCVNS3NS3p53NS3TGF-βRibavirinIL-12THCVD(HDV)DDHDVHDVRNA(nitricoxide,NO)(prostaglandin,PG)(endothelin-1,ET-1)portal-systemiccollaterals(PSC)ET-1PSCETAETBETBETindomethacinPGglypressinthrombopoietin(lasercapturemicrodissection,LCM)SEREXCT(AAA/AAA)4-6385372,35886382,45387483,27588493,33789615,09016616q(lossofheterozygosity)(percutaneousethanolinjection)(HP)spinalafferentvagalafferentsubstancePHPPCREIAHPprolactinCCKAHLAclassIIDNAtypingDQB1*0602DQB1*0301RIG(MSI-H)MLH1L-canavanineendothelin22.5,3954-6423.1,1264-65Tyrosinaseplasmid4-6485573,23886633,18887513,05488765,05689805,39516724.2,9804-66FK506bFGF(apoptosis)NONO25.2,0304-6726.4-658513679861154587171,146881491589191,1264-6685251,32886231,10987321,75688382,09489472,9801681,8434-6827.1,7054-69LeberDNA28.8614-70PUVAT29.4-6785208458620697872692188441,33089442,0304-6885241,46586231,23187241,39288251,45089301,8434-698518987861989787211,14688251,