放射性离子束9C的细胞生物学效应

50520053416(,730000;,263-855,.E-mail:[e-mail]),(RIB),(NIRS)(HIMAC)9C,9C12C(RBE).:40mm10mm5%,430MeV/u1.8×109/s12C,9C9.07×10−6,82.88%,,10mm,89.6%,0.5Gy/h.Bragg,9CRBE5.28,12CRBE2.93,9CRBE12C1.8,9CBragg,12C,.RBE[1~3],BraggRBE.:GSI[4],(raster),NIRS[5],,.,.,,12C,.(RIB),,β+,.GSI12C-(PET)[6],,;NIRS,11C-10C-,[7],β+.,,,9C-,8B-β+,9C126.5ms,β+,(1.21MeV)α(0.603MeV)[8],:9C,,,.,,.,,:αRBE(4~6)[9].9C(),,9C,,.,9C,2002NIRS-HIMAC,.9C12C,,9C,,HIMAC(SBL,1),9C.11.19CHIMAC-SBL,430MeV/u1.8×109/s12C,9C505200531HIMAC(SBL),9C,24mm,40mm56mm,3.5mm10mm,.,(PSD),,[10].SBL(PI),TOF∆E,1,TOFF1F2,0.5mm.TOF10m,.0.3mm(SSD)F2∆E,.TOF∆E,[7],.,12C,SBL(SEM),105109/[11].9C12C,9C.1.29C12C9C,,(PPPC),(LET),120mm(PPIC)12.7mm(1µm)(TEPC),LETy.9C12C,.,97mm12C430MeV/u290MeV/u,322MeV/u9C.,12C,12C9C.,12C9C.1.31.3.1(HSG),.,HSG4105/mL10(,100µm),10mm,,,,,,SBL.1.3.22,,Bragg10,:130.8,135.2,2Bragg(9C)(/),.21.3.32.19C(CFM).,,,3:9C39C418(5%),9.07×10−682.88%.4,9C(Bρ),,0.5%.±0.25%,Gauss,Gauss.26.1meV·u−1·c−1838.9meV·u−1·c−1(c).49C(Bρ)(0.5%)9C,8B-,10C-12C,8.72%,3.13%3.00%.3He9C,9C,[12].5PSD,9C,:,Z=6(9C,10C12C)Z=5(8B),Z=2(3He),.5PSD9C2.29C(36.850.3A),20mm93.8%,,0.28~0.3Gy/h.3,10mm89.6%,,0.5Gy/h.69C.6(a)3(b)9C(mm)():Bragg,9C,TEPCLETLET,,TEPC9C.79CLET2.412C17,15mm94.9%.,12C0.5Gy/h.Bragg,PPIC12C,9C,8.89C12C99C-()12C-()Bragg10HSG420:9C0.505,1.0121.75Gy;12C0.4,0.81.35Gy..2.6HSG50%9C12CRBE99C12C,(0.5Gy/h,,30min)γ-,HSG50%RBE,10.,9C12C(GH),9CRBE5.28,12CRBE2.93,,,9CRBE12C1.8.3(1)10:,9C-RBE12C-1.8.:Bragg,,9C-12C-,9C-.10Bragg10HSG50%9C-12C-RBE(2)9:HSGγ-(0.5Gy/h),,,-γ-,(0.5Gy/min)-.:,.(3),9C-(0.5Gy/h),.,5Gy/min.,GH(2)0.5Gy/h0.900.76Gy/h,0.83Gy/h(0.014Gy/min),,(5Gy/min),357,12C6.4×1011/s.,9C-12C-.(:15P150).1CastroJR.Resultsofheavyiontherapy.RadiatEnvironBiophys,1995,34:45~48[DOI]2Schulz-ErnterD,HabererT,JaekelO,etal.Radiotherapyforchrodomasandlow-gradechondrosarcomasoftheskullbasewithcarbonions.IntJRadiatOncolBiolPhys,2002,53:36~42[DOI]3MiyamotoT,BabaM,SugawaraT,etal.CarbonionradiotherapyforstageInon-smallcelllungcancer.RadiotherOncol,2003,66:127~140[DOI]4HabererT,BecherW,SchardtD,etal.Magneticscanningsystemforheavyiontherapy.NuclInstrMeth,1993,A330:296~3055MinoharaS,KanaiT,EndoM,etal.Respiratorygatedirradiationsystemforheavy-ionradiotherapy.IntJRadiatOncolBiolPhys,2000,47:1097~1103[DOI]6EnghardtW,DebusJ,HabererT,etal.Positronemissiontomo-graphyforqualityassuranceofcancertherapywithlightionbeams.NuclPhys,1999,A654:1047c~1050c7KanazawaM,KitagawaA,KoudaS,etal.ApplicationofanRI-beamforcancertherapy:in-vivoverificationoftheion-beamrangebymeansofpositronimaging.NuclPhys,2002,A701:244c~252c8GeteE,BuchmannL,AzumaR.E,etal.β-delayedparticledecayof9CandtheA=9,T=1/2nuclearsystem:Experiment,data,andphenomenologicalanalysis.PhysRev,2000,C61:0643109BelliM,CeraF,CherubiniR,etal.Inactivationandmutationin-ductioninV79cellsbylowenergyprotons:re-evaluationoftheresultsattheLNLfacility.IntJRadiatBiol,1993,63:331~33710UrakabeE,KanaiT,KanazawaM,etal.Spotscanningusingra-dioactive11Cbeamsforheavy-ionradiotherapy.JpnJApplPhys,2001,40:2540~2548[DOI]11TomitaniT,PawelkeJ,KanazawaM,etal.Washoutstudiesof11CinrabbitthighmuscleimplantedbysecondarybeamsofHIMAC.PhysMedBiol,2003,48:875~889[DOI]12SummererK,BlankB.Modifiedempiricalparameterizationoffragmentationcross-sections.PhysRev,2000,C61:034607(2004-12-17,2005-01-20)