新一代生物医用材料

:20374013;(03JC14023);;:(1967)),,,1997,;*刘盛辉1,郎美东2*(11浙江工业大学化学工程与材料学院,杭州31001421华东理工大学材料科学与工程学院,上海200237):;;,:;;;;(BiomedicalMaterials)(Biomaterials),,,,1第一代生物医用材料,,,3:,,/0,,;,,,[1]80,,,198040,[2],5~252第二代生物医用材料,;,#113#6,,;,,,BioglassoR45S5(Na2O)CaO)P2O5)SiO2),11,,,[3],CeraboneoR(MgO)CaO)P2O5)SiO2-F),,,,[4],,,,/0,,B-(TricalciumPhosphate,B-TCP),,,,,[5]1962AmericanCyanamidCompany1970(,Polyglycolide,PGA),Dexon,,Vicryl()Maxon()PDS(),(,Polylactide,PLA)3第三代生物医用材料,;,,,,,,(1),,,,,,,,(CellandGene-ActivatingMaterials)[2],,[6~8]4组织工程(TissueEngineering),,[9],(),,,;(),#114#200512,,[10,11]1Figure1Thethreedifferentdevelopingstagesofthebiomedicalmaterialsanditscharacteristic1987,LangerVacantiScience[9],,NASANIHMITHarvardAdvancedTissue,1995,/0,60,25%ApligrafFDA,[8,12];;,5人工细胞外基质,,,,:;;;;,[6,12](ExtracellularMatrix,ECM)-,6-[13]ECM,,,,;,ECM,[6,14~16]ECM,,,:(1),;(2):#115#6,;(3):,90%,,,;(4):,,;(5):,;(6)[5,16,17]6组织工程对生物材料的挑战ECM,,,[18],,,,,[19],,:,[20],,,,,[21]ECM,(Tissue-engineeredConstructs)[6,11,16,22],ECM,,[23](InSituTissueRegeneration):(),,,,[24,25],,,,,[26][27],ECM,[16,28][2,6],,,[29,30][31,32],[33]ECMECM,[16]#116#200512,[10],,,[34,35],,,7结语[2,6,36][2,29,31,34][37,38]:,,,,,,,,参考文献:[1]HenchLL.Science,1980,208:826~6311[2]HenchLLandPolakJM.Science,2002,295:1014~10171[3]HenchLL.JAmCeramSoc,1998,81:1705~17281[4],.,2000,1:45~511[5]JacobyM.ChemEngNews,2001,79(6):30~351[6]GriffithLG,NaughtonG.Science,2002,295:1009~10141[7]StrainAJ,NeubergerJM.Science,2002,295:1005~10081[8]ParenteauN.ScientificAmerican,1999,280(4):83~841[9]LangerR,VacantiJP.Science,1993,260:920~9261[10]MahoneyMJ,SaltzmanWM.NatureBiotech,2001,19:934~9391[11]BiancoP,RobeyPG.Nature,2001,414:118~1211[12]ZandonellaC.Nature,2003,421:884~8861[13]WilliamsDF.MaterialsScienceandTechnologyVol14:MedicalandDentalMaterials.Weinheim;NewYork;Basel;Cambridge:VCH,1992:179~2081[14],.,2002,33(1):69~731[15],.,2002,24(1):47~491[16]KimBS,MooneyDJ.TrendsinBiotech,1998,16:224~2301[17],.,2002,12(16):101~1021[18]RouhiAM.ChemEngNews,1999,77(3):51~591[19]RabkinE,SchoenFJ.CardiovascPathol,2002,11(6):305~3171[20]RatnerBD.MacromolSymp,1998,130:327~3351[21].,2002,8(5):267~2691[22]SolterD,GearhartJ.Science,1999,283:1468~14701[23]LevenbergS,HuangNF,LangerR,etal.ProcNatlAcadSciUSA,2003,100(22):12741~127461[24]MarlerJJ,LangerR,VacantiJP,etal.AdvDrugDelivRev,1998,33:165~1821[25]QuirkRA,ChanWC,DaviesMC,etal.Biomaterials,2001,22:865~8721[26],.,2002,25(4):180~1841[27]KlokH,HwangJJ,IyerSN,etal.Macromolecules,2002,35:746~7591[28]MalkarNB,Lauer-FieldsJL,JuskaD,etal.Biomacromolecules,2003,4:518~5281[29]RyuHS,LeeJK,SeoJH,etal.JBiomedMaterRes,2004,68A:79~891(128)#117#6[28]GeddeUW.PolymerPhysics.Chapman&Hall:London,1995.[29]TomaL,TomaS,SubiranaJA.Mocromolecules,1998,31(7):2328~2334.[30]GilraN,PanagiotopoulosAZ,CohenC.Macromolecules,2001,34(17):6090~6096.[31],,,.,1993,6(1):41~45.[32],,.,2000,21(7):1146~1148.[33],.,1991,5:577~583.[34],,.,1994,5:565~572.ApplicationofMonteCarloTechnologyinPolymerScienceLEIJun1,ZHANGZhen_jun1,LIUBin1,LIGuo_liang2,SHENKai_zhi1(1CollegeofPolymerScience&EngineeringofSichuanUniversity,Chengdu610065,China2RoyalBuildingSystem(China)Co.Ltd,Shanghai201613,China)Abstract:ThispaperintroducesthehistoryandcharactersofMonteCarlotechnologyanditswideapplicationinpolymerscience.Theauthoralsomadeanoutlookofitsfuture.Keywords:Polymer;MonteCarlo;Computersimulation;(117)[30],,,.,2001,7:407~4101[31]RoetherJA,JGoughE,BoccacciniAR,etal.JMaterSciMaterinMed,2002,13:1207~12141[32],,,.(),2003,66(w106):1~61[33]RoetherJA,BoccacciniAR,HenchLL,etal.Biomaterials,2002,23:3871~38781[34]LangMD,ChuCC.JPolymSci,PolymChem,2001,39:4214~42261[35]LangMD,ChuCC.USP6830147,2004-12-14.[36]VogelV,BaneyxG.AnnuRevBiomedEng,2003,5:441~4631[37],,.,2002,16(5):325~3281[38]LendleinA,LangerR.Science,2002,296:1673~16761New-generationBiomedicalMaterialsLIUSheng-hui1,LANGMe-idong2*(11CollegeofChemicalEngineeringandMaterialsScience,ZhejiangUniversityofTechnology,Hangzhou310014,China;21SchoolofMaterialsScienceandEngineering,EastChinaUniversityofScienceandTechnology,Shanghai200237,China)Abstract:Firs-tgenerationbiomedicalmaterialswerebiocompatibleandbioinertmaterials.Second-generationbiomaterialsweredesignedtobeeitherresorbableorbioactive.Third-generationbiomaterialsarecombiningthesetwoproperties.Thesenewgenerationbiomaterialsaredesignedastheextracellularmatrixtoactivategenesandelicitthespecificinteractionswithcell,andtherebytodirectcellproliferation,differentiation,organization,andlasttorepairorregeneratethelivingtissuesandorgans.Keywords:Third-generationbiomedicalmaterials;Tissueengineering;Cellandgene-activation;Extracellularmatrix;Bioactivity#128#200512