溶胶-凝胶法在制备生物掺杂纳米复合材料中的应用

-2317-∗1000392004-05-231967E-mail:[e-mail],Tel:[phone].-sol-gel--TB39A1001-97312004-2317-04121863863[1]()[2,3]-sol-gelsol-gel-/[4~10]2--sol-gel60[11]()()sol-gel2318200435sol-gelsol-gel[3,11,12]3-[13]CONHpH[13]110010nm100030nm-2~50nmsol-gelsol-gelsol-gelpH[4~7]()sol-gelsol-gel-[7](300nm)-3.1-(sol)/-23193.23.3pH-(sol-gel)80sol-gel[14]sol-gel901990Braun[15]TMOSTEOSsol-gel()(ALP)()β-()SiO2Hench[16]1991Ellerby[17]1992(CuZnSOD)CSiO2sol-gel/[4~10]SiO2TiO2[18]ZrO2[19]V2O5[20]sol-gel[4~10]sol-gel[7](1)sol-gel(2)sol-gel(3)sol-gel(4)sol-gel4sol-gelsol-gelsol-gelsol-gelSiO2A12O3TiO2ZrO22320200435ORMOSILS[1].[J].,2002,1-2:60-62.[2]SanchezC,Soler-IlliaGJdeAA,RibotF,etal.signedhybridorganic-inorganicnanocompositesfromfunctionalnanobuildingblocks[J].ChemMater,2001,13:3061-3083.[3]YanoS,IwataK,KuritaK.Physicalpropertiesandstructureoforganic-inorganichybridmaterialsproducedbysol-gelprocess[J].MaterialsScienceandEngineeringC,1998,6:75-9.[4]GillI.Bio-dopednanocompositepolymers:sol-gelbioen-capsulates[J].ChemMater,2001,13:3404-3421.[5]LiuDM,ChenIW.Encapsulationofproteinmoleculesintransparentporoussilicamatricesviaanaqueouscolloidalsol-gelprocess[J].Actamater,1999,47(18):4535-4544.[6]DunnB,MillerJM,DaveBC,etal.StrategiesforEncapsulatingbiomoleculesinsol-gelmatrices[J].Actamater1998,46(3):737-741.[7],,,.-[J].,1998:12,26-32.[8],.-[J].,2001,18(4):629-632.[9],,.[J].,2000,5:14-19.[10],,.-[J].,1999,27(8):982-988.[11]JeffreyBrinkerC,SchererGW.Sol-gelscience:Thephysicsandchemistryofsol-gelprocessing[C].SanDiego:AcademicPress,CA,1990:1-97.[12]LiZhihong,WuDong,SunYuhan,etal.Fractalsofsilicaaggregates[J].StudSurfSciCatal,2001,135:353.[13]DonaldVoet,JudithGVoet.FundamentalsofBiochemistry[C].JohnWiley&Sons,Inc,Publishers,1997:1.[14]AvnirD,LevyD,ReisfldR.Thenatureofthesilicacageasreflectedbyspectralchangesandenhancedphotostabilityoftrappedrodamine6G[J].JPhyChem,1984,88:5956-5959.[15]BraunS,RappoportS,ZusmanR,etal.Biochemicallyactivesol-gelglass:thetrappingofenzymes[J].Mater.Lett,1990,10(1-2):1-5.[16]HenchLL.Bioceramicsfromconcepttoclinic[J].JAmCeramSoc,1991,74(7):1487.[17]EllerbyLM,NishidaCR,NishidaF,etal.Encapsulationofproteinintransparentporoussilicateglassespreparedbysol-gelmethod[J].Science,1992,255:1113-1115.[18]KurokawaY,SanoT,OhtaH,etal.Immobilizationofenzymeontocellulose-titaniumoxidecompositefiber[J].BiotechnologyandBioengineering,1993,42(3):394-397.[19]KurokawaY,OhtaH,OkuboM,etal.Formationanduseinenzymeimmobilizationofcelluloseacetate-metalalkoxidegels[J].CarbohydratePolymers,1994,23(1):1-4.[20]GlezerV,LevO.Sol-gelvanadiumpentaoxideglucosebiosensor[J].JAmChemSoc,1993,115:2533-2534.Applicationofsol-gelmethodinpreparationofbio-dopednanocompositeLIZhi-hong,WUZhong-hua,WUZi-yu(FacilityofSynchrotronRadiation,InstituteofHighEnergyPhysics,ChineseAcademyofSciences,Beijing100039,China)AbstractInrecentyears,therehasbeenagreatdevelopmentintheapplicationofsol-gelmethodinpreparationofbio-dopednanocomposite.Inthisarticle,thesol-gelprocessanditsuseinpreparationofbio-dopednanocompositearebrieflyreviewed.Themaindiscussionsaredevotedtoprocess,advantagesandpropertiesofsol-gelencapsulationmethod.Thetreadinthisfieldisforecasted.Keywordssol-gelencapsulationbioactivenanocomposite