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,(,071002):,,.,.:;;;:Q631:A:1000-1565(2003)02-0198-06,.,.,.,,,,.1,,,,:1.1,.,,,2,,,,.,,,..1.2,,,.,.,,,,.,,.:2002-12-10:(1944-),,,,.23220036()JournalofHebeiUniversity(NaturalScienceEdition)Vol.23No.2Jun.20031.3,,2:,;,.,,,..1.4,.,..,,,,.1.5,,,.,,.,,,,,.,,,,,.,5.2,.,,.2.1,DNA.,.,,,,DNA,..[1],,,,,,,,DNA,,.,,.1970Berns[2],,.2080,,[3,4],.Weber[5],DNA,,.[6]1988,.[7],,-1,3-pBLGC,,.,,.[8],,9912:A+r,,,,DNA.[9],,,.,,DNADNA,DNA,DNA.[10]He-NeDNA,,He-NeDNA,.He-NeDNA,DNA.2.2.,..1987[27].-,,,,,-,.,,,.-.,,,.[11],,,,,,,..,,.[12]He-Ne,,,..,.,.2.3,.,,15,.1987,,,1min,,.,,,.,.,.,.[13,14]He-Ne.,,,,10min,20%27%.,,,2,He-Ne.,ASP3.396,[15]CO2,,CO2ASP3.396.,,,,48.5%.B2,002()2003,.[16,27]He-Ne.,AG,AG,,,,.,,.3,,,,..,,40,..,,,,..,.,,,,[17,18].,[19]He-Ne.6395J/cm2He-Ne,3,5,710d,1,10min,,,,,,.,,10d,,,.[20]He-NeT.,T,,,.,,,.(HPD).Bowen,,,,.5(5ALA)(PDT)Bowen[21],,,.[22]ALAPDTBowen,,,,,44,,ALA-PDTBowen,,Bowen.[23])HPD,,.,DA,5-,,,.[24].,He-Ne,(DA),5-(5-HT),(NF)..,,[25]He-NeLangerhans;[26][31]Nd:YAG,.1022:,,.4,,,,,,,.,,,,X,,,,,,,,,,.,.,,,.:[1],.[J].,1999(1):70-74.[2]BERNSMW,DONALDER.CellsurgerybyLaser[J].ScientificAmerican,1970,222(2):99-104.[3]BERNSMW,AISTI,EDWARDSJ,etal.Lasermicrosurgeryincellanddevelopment[J].BiologyScience,1980,213:505-513.[4]WEBERG,MONAJEMBASHIS,GREULICHKO,etal.InjectionofDNAintoplantcellswithaUv-lasermicrobeam[J].Naturwissenschaften.1988,75:35-36.[5]WEBERG,MONAJEMBASHIS,WOLPPRUMJ,etal.Geneticchangeincludeinhigherplautcellbyalasermicrobeam[J].PhysioloyyPlanlarum,1990,79:190-193.[6].[J].,1988(4):198-201.[7],,,.[J].,2000(3):279-283.[8].[J].,1991(4):313-316.[9]KARUGT.Molceularmachanismofthetherapeuticeffectoflowintensitylaserradiation[J].LasersLifeSci,1988,2:53-74.[10],,.DNA[J].,1999(4):275-278.[11].[J].,1983(4):23-26.[12].[J].,1980(1):15-17.[13],,,.He-Ne[J].,2001(1):23-26.[14],,,.He-Ne[J].,1999(2):127-129.[15],,.CO2ASP.3.396[J].,1985,5:221-222.[16].He-Ne[J].,1991(6):256-259.[17]MESTERE.Thebiomedicaleffectoflaserapplication[J].LasersSurgMed,1985,5:31-39.[18]BASFORDJR.Low-energycontroversiesandnewresearchfindings[J].LasersSurgMed,1989(9):1-5.[19],,,.He-Ne[J].,2000(2):109-112.[20],.He-NeT[J].,1999(1):33-35.[21]SVANBERGK,ANDERSSONT,KILLANDERD,etal.Photodynamictherapyofnon-melanomamalighantlumoursoftheshinusingtopicaldelta-aminolevulinicacidsensitizationandlaserirradiation[J].BrJDermatol,1994,130:743-751.[22],,,.5-Bowen[J].,1999(1):9-11.[23],,,.[J].,1999(1):20-22.202()2003[24],,,.[J].,1999(1):36-38.[25],,.He-NeLangerhans[J].,2000(4):231-233.[26],,,.[J].,1999(4):256-260.[27].[M].:,1995.[28].[M].:,1987.[29].-[M].:,1999.[30],.[M].:,1990.[31],,.Nd:YAG[J].,2000(1):13-17.InteractionofLaserwithTissueandItsApplicationLIXin2hua,HUAISu2fang(CollegeofPhysicsScienceandTechnology,HebeiUniversity,Baoding071002,China)Abstract:Themainmechanismoftheapplicationoflaserinbiologyandmedicineisthatthemoleculeandatomofthetissuecanabsorbtheenergyoflaserandultimatelytransformitintootherforms.Inthispaper,thebiologicaleffectproducedbyinteractionbetweenlaserandtissueisintroducedbriefly,andthelatestprogressandprospectabouttheapplicationoflaserinbiologyandmedicinearereported.Keywords:laser;tissue;interaction;application(:)3022: