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11.Honma,Y.,Akimoto,M.Therapeuticstrategyusingphenotypicmodulationofcancercellsbydifferentiation-inducingagents.CancerScience,98:1643-1651,2007.2.Horie,A.,Akimoto,M.,Tsumura,H.,Makishima,M.,Taketani,T.,Yamaguchi,S.,Honma,Y.Inductionofdifferentiationofmyeloidleukemiacellsinprimarycultureinresponsetolithocholicacidacetate,abilederivative,andcooperativeeffectswithanotherdifferentiationinducer,cotyleninA.LeukRes32:1112-1123,2008.3.IshikawaK,TakenagaK,AkimotoM,KoshikawaN,YamaguchiA,ImanishiH,NakadaK,HonmaY,HayashiJ-I.ROS-generatingMitochondrialDNAMutationsCanRegulateTumorCellMetastasis.Science320:661-664,2008.4.KasukabeT,Okabe-KadoJ,HonmaY.CotyleninA,anewdifferentiationinducer,andrapamycincooperativelyinhibitgrowthofcancercellsthroughinductionofcyclinG2.CancerScience99:1693-1698,2008.5.IshikawaK,HashizumeO,KoshikawaN,FukudaS,NakadaK,TakenagaK,HayashiJ.EnhancedglycolysisinducedbymtDNAmutationsdoesnotregulatemetastasis.FEBSLett.582:3525-3530,2008.6.IshikawaK,KoshikawaN,TakenagaK,NakadaK,HayashiJ.ReversibleregulationofmetastasisbyROS-generatingmtDNAmutations.Mitochondrion.8:339-344,2008.7..,26(13):2067-2073,2008.2II1.YoshioHonma,MihoAkimoto,TakeshiSassa,NobuoKato:Fusicoccinderivativesastherapeuticagentsbasedoninductionofdifferentiation.AACR/NCI/EORTCInternationalConference.10.22-28,2007.MosconeWestConventionCenter,SanFrancisco.2..ReversiblecontrolofmetastasisbyapathogenicmtDNAmutationinND610.3-5,2007.3..Anti-tumoractivityofanovelcongener(ISIR-005)ofcotyleninA.10.3-5,2007.4..DetectionofNM-23interactingproteinsandtheirpossibleroleonpoortreatmentoutcomeinleukemia.10.3-5,2007.5..CotyleninA,adifferentiation-inducingagent,inhibitsrapamycin-inducedfeedbackactivationofAktsignaling.10.3-5,2007.6..ND6.7.9-10,2007.7...10.11-15,2007.8..NM23.10.11-15,2007.9..NOD.212.1.2007.10.HonmaY,AkimotoM,SassaT,KatoN.Fusicoccinderivative(ISIR-005)suppressionanchorage-independentgrowthofcancercellsthroughanoikisactivation.20thEORTC-NCI-AACRSymposiumonMolecularTargetsandCancerTherapeutics.10.21-24,2008.GenevaConvention3Center.11..CotyleninAISIR-00514.3.3..6.26-27,2008.12..CotyleninAISIR-00514.3.3..10.28-30,2008.13..RapamycinAktcotyleninA..10.28-30,2008.14..nm23..10.28-30,2008.15..Hedgehogcylcopamine..10.10-12,2008.16..MCL-1.67,10.28-30,2008.17..HIF-2CD133.67,10.28-30,2008.18..ROSDNA.67,10.28-30,2008.19.TakenagaK.Controlofmetastasisbyreactiveoxygenspecies-generatingmitochondrialDNAmutationsintumorcells.HiroshimaCancerSeminar-ThreeUniversities’ConsortiumInternationalSymposium“RecentProgressinPathogenesisandManagementofColorectalCancer”.11.9,2008.Hiroshima.20.TakenagaK.Contributionofpathogenicmitochondrialmutationstoapoptosisresistanceandmetastasisoftumorcells.KashiwaSymposiumonCancerBiology2008“Oncologicimpactofcancermetabolism”.11.14,2008,NationalCancerCenterHospitalEast,Kashiwa.421.TakenagaK.ControlofhypoxicresponseandmetastasisbypathogenicmtDNAmutations.SpecialLecture.The6thAnnualMeetingfortheJapaneseAssociationforCancerandHypoxiaResearch.11.29,2008,Hiroshima.

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