生物利用率在食品污染物风险评估中的应用

————17—1.J.20031513-6.2.J.2003153341-345.3.J.20051713-6.1211.1000502.100007、、、。、、。、、。。R15X820.4A1004-8456201101-0017-06ApplicationofbioavailabilityintheriskassessmentoffoodcontaminantsLiFengqinXuJiaoLiuSanaNationalInstituteofNutritionandFoodSafetyChinaCDCBeijing100050ChinaAbstractOralbioavailabilityisdefinedasafractionoftheadministereddoseofasubstancethateventutallybeingreachedthecentralbloodcompartmentafterbeingreleasedfromfoodmatrixingastrointestinaltractabsorbedbyintestinalepithelialcellsandmetabolizedinliverandtheoralbioavailabilityisafractionofanexternalexposuredosethathavingeffectsonhumanbeings.Themostusefulapproachtostudythebioavailabilityoffoodcontaminantsisbasedonaninvitrodigestionmodelthatsimulatinghumanphysiologicalconditionsofgastrointestinaldigestionabsorptiontransportandsoforth.Foodingredientsandfatcontentchemicalandphysicalpropertiesofsubstancestheconcentrationofnutrientsotherthantargetedsubstancesinfoodsthenutritionalstatusofthebodyandsoforthwillhaveabiginfluenceonthebioavailabilityofthesubstance.Theapplicationofbioavailabilityinriskassessmentoffoodcontaminantsisreviewed.KeywordsBioavailabilityfoodcontaminan[e-mail]、、、、、/。。、。、。1。—18—CHINESEJOURNALOFFOODHYGIENE2011231bioaccessbility。、bioavailability。FFB、FA、FM、F=FB×FA×FM。。。relativeabsorptionfactorRAFRAFrelativebioavailabilityofadjustmentRBA。2。20、、、、、、。、pH、、。、、—。、、。。。。、、、、。33.1AB。aBaPBaP69%62%44%47%1.41－2B1aflatoxinB1AFB1、AochratoxinAOA91%94%63%100%3－4。Hack5PAHspolychlorinatedbiphenylsPCBs。Tang6PAHs9.2%～60.5%。。permanentorganicpollutantsPOPs。Guan8PCBs、、、PCBs702、377、10825.5ng/gPCBs。4PCB0.5212、1.41、0.99————19—0.27ng/g。2PCBs3%PCB1517%PCB286%PCBs25%PCB187PCB1012。PCB。、、。3.2PCBs、、POPs。Guan7PCBsPCBsPCBsPCBs。、3%15%0.1%。PCBs、2PCBs93%PCBs49%27%51%。toxicequivalentsTEQs40%PCBs9%。PCB。PCBsPCBs85∶1559∶41PCBs2。、PCBs。3.3。Guan7PCBs/KOA、P0.05/KOWP0.01。PCBsPCBPCB70、74、101、105、151、128、158、157153。PCB。3.4。、、。8。、、1995、。Reeves9－11109Cd109Cd90%4109Cd60%109Cd。109Cd、24h40%109Cd4%109Cd、、109Cd20%109Cd。、109Cd1.1、0.52、。Vahter12。—20—CHINESEJOURNALOFFOODHYGIENE20112313、。。10———、13。。、、、、。、、、/。3.5、、。、、。7%～15%40%～53%14。50%30%。60%RAF=0.3/0.5=0.6。4。AFB1。。。AFB1OA、、3。AFB1OA20%AFB1OAAFB1OA15%。34。AFB175%AFB1Caco-2Caco-2AFB1AFB150%AFB175%AFB14。Caco-2。。。。100%。Σ×。、。、————21—。relativebioavailabilityfactorRelF。RelF。、100%。。Jack15Watson11%24%。As3+As5+、。。Watson。31150μg/g。。。、。0.4mg/kg。。。5、Caco-2、、、、。/。。1SAHUQUILLOABARBERARFARRER.BioaccessibilityofcalciumironandzincfromthreelegumesamplesJ.NahrungFood200347438-441.2KENNEFICKSCASHMANKD.InhibitoryeffectofwheatfibreextractoncalciumabsorptioninCaco-2cellsevidenceforaroleofassociatedphytateratherthanfibreJ.EurJNutr20003912-17.3VERSANTVOORTCHMEvandeKAMPROMPELBERGCJM.DevelopmentandapplicabilityofaninvitrodigestionmodelinassessingthebioaccessibilityofcontaminantsfromfoodRIVMreport320102002R.Bilthoven2004.4CAROLIENHMVERSANTVOORTOOMENAGetal.ApplicabilityofaninvitrodigestionmodelinassessingthebioaccessibilityofmycotoxinsfromfoodJ.FoodandChemicalToxicology20054331-40.5HACKASELENKAF.MobilizationofPAHandPCBfromcontaminatedsoilusingadigestivetractmodelJ.Toxicologyletters199688199-210.6TANGXYTANGLZHUYGetal.AssessmentofthebioaccessibilityofpolyclicaromatichydrocarbonsinsoilsfromBeijingusinganinvitrotestJ.Environmentalpollution2006140279-285.7GUANHXYUYJANETKITYCetal.Bioaccessibilityofpolychlorinatedbiphenylsindifferentfoodsusinganinvitrodigestionmethod.EnvironmentalpollutionJ.20081561218-1226.8PHILIPGRRUFUSLC.BioavailabilityasanissueinriskassessmentandmanagementoffoodcadmiumAreviewJ.Scienceofthetotalenvironment200839813-19.9REEVESPGCHANEYRL.MineralstatusoffemaleratsaffectstheabsorptionandorgandistributionofdietarycadmiumderivedfromediblesunflowerkernelsHelianthusnnuusL.J.EnvironRes200185215-225.10REEVESPGCHANEYRL.Nutritionalstatusaffectstheabsorptionandwhole-bodyandorganretentionofcadmiuminratsfedrice-baseddietsJ.EnvironSciTechnol2002361632-1684.—22—CHINESEJOURNALOFFOODHYGIENE201123111REEVESPGCHANEYRL.Marginalnutritionalstatusofzincironandcalciumincreasescadmiumretentionintheduodenumandotherorgansofratsfedrice-baseddietsJ.EnvironRes.200496311-322.12VAHTERMBERGLUNDMNERMELLBetal.BioavailabilityofcadmiumfromshellfishandmixeddietinwomenJ.ToxicolApplPharmacol1996136332-41.13SIMMONSRWPONGSAKULPCHANEYRL.TherelativeexclusionofzincandironfromricegraininrelationtoricegraincadmiumImplicationsforhumanhealthJ.PlantSoil2003257163-70.14OOMENAGVERSANTVOORTCHMDUITSMRetal.ApplicationofinvitrodigestionmodelstoassessreleaseofleadandphthalatefromtoymatricesandazodyesfromtextileRIVMreport320102003/2004R.Bilthoven2004.15NGJCKRATZMANNASMQIALixiaetal.Speciationandabsolutebioavailabilityriskassessmentofarsenic-contaminatedsitesinaresidentialsuburbinCanberraJ.Analyst19981235889-892.100021－。R15X820.4A1004-8456201101-0022-04Derivationofhealth-basedguidancevaluesinfoodsafetyriskassessmentJiaXudongNationalInstituteforNutritionandFoodSafetyChinaCDCBeijing100021ChinaAbstractByintroducingtheprocessofderivinghealth-basedguidancevaluest