生物活性物质部

17I.II.III.IV.V.LECT2VI.VII.VIII.QDQDThomasL.LetoKarl-HeinzKrauseDavidJayneDavidScottRichardWattsSeemaAhujaJimKoopman()MartinEichner(Tubercular)NielsBeckerTatyanaNovikovaPenzaRegionalTubercularProphylscticCenterV.D.KrevchikPenzaRegionalTubercularProphylscticCenterM.B.SemenovPenzaRegionalTubercularProphylscticCenterRowlandKaoVuTuongVanVanDinkTrangPhungThiBichThuyI.1.ABCABCS.cerevisiaeABC−cyclodepsipeptidesFK506C.albicansABCCaCdr1pCaCdr2p[]1.(1)A431EGFSDS-PAGEERKp90RSKAktS6RmTORmTORp70S6KmTORT389mTOR(2)polyHEMADLD-1anoikiscaspase3anoikis[](3)13810VEGFR1(Flt-1)VEGFR2(KDR)[]2.(1)EBEBNA-1TAF-IαβTAF-IαβEBNA-1EBNA-1EBNA-1TAF-IinvitroTAF-1EBNA-1Gly-Argrepeat293TinvivoEBNA-1TAF-Iαβ293TinvivoCAcidicregion[](2)CNS5AHCVNS5A3xFLAGHeLaHeLaSDS-PAGE[](3)LANALANAEts-1VEGFreal-timePCRVEGFLANADaxxEts-1293TLANADaxxDaxxEts-1DaxxEts-1LANADaxxEts-1DaxxLANAEts-1LANADaxx(4)HHV8LANABrd4BETBrd4LANALANA11401162Brd4495720Brd4PTEFb(Cdk9/CyclinT1)RNApolIIHEK293TFlagLANAHABrd4LANABrd4PTEFbLANABrd4PTEFbLANABrd4II.1.(1)AD1-8u-sec6-4GFPSec6pSec6p37sec6-4p37sec6-4CRFPCandidaalbicansABCCaCdr1p2337[ErwinLampingBrianC.MonkRichardD.Cannon](2)ABCC.albicansABCCaCdr1pCaCdr1pFK506FK506FK506CaCDR1ORFFK506CaCdr1pFK506[](3)Candidaalbicansβ-β-(Gsc1p)C.albicansGSC1GSC1645heterozygousS/RS/∆R/∆S/SR/R645[](4)CandidaalbicansC.albicans93197453[](5)CandidaalbicansCaYvh1pCaYVH1CaYVH1ACT1CaYvh1p[](6)CandidaalbicansC.albicans2920CaSIT4CaYVH1[](7)CandidaalbicansC.albicansCaFAD2CaFAD3S.cerevisiaeGCCaFad2pCaFad3pCaFAD2CaFAD3C.albicans[]2.(1)CryptococcusneoformansMPO(MPO-KO)MPO[NobuyoMaeda](2)C.albicans-(CAWS)C.albicansCAWSCAWSpH2CAWS1pH7IL-6KCRANTESICAM-1KCCAWSpH2NMRC.albicans-pHCAWSCAWS[PeterWard]III.(1)MPO-ANCAANCASCG/KjTh1/Th2[](2)MPO-ANCASCG/KjSCG/KjMPO-ANCApauci-immuneSCG/KjMan-1[](3)ANCA(IVIg)ANCA(IVIg)ACNA13[](4)[](5)MPO-ANCABSAMPO-ANCA[](6)MPO-ANCAMPO-ANCAMPO-ANCAMPO-ANCAICAM-1FabMPOMPOMPO[](7)CD69CD69CD69CAWSCD69[](8)acutelunginjury:ALIacuterespiratorydistresssyndorome:ARDSprimarycultureinvitroE-selectinICAM-1VCAM-1invitro[](9)MPOMPO-ANCAMPO-ANCANHaHbMPOMPO-ANCAMPOHaHbMPOV113N114E116-P123P154G155N157E180-P182R185N186N215-D218N[]IV.(1)MPO-ANCAIn-vivoImaginganti-mMPOinvitro[](2)QuantumDotMPOQuantumdot:QD4MPOMPO[]V.LECT2(1)CandidaalbicansLECT2LECT2LECT2NKNKTγC.albicansLECT2(BALB/c)C.albicansLECT2LECT2C.albicans[](2)LECT2EBLECT2LECT2LECT2BALB/cLECT2LECT2−LECT2[](3)LECT2LECT2LECT2LECT2insituhybridizationinsituLECT2mRNA[]VI.1.(1)NocardiafarcinicaIFM10152nocobactinnocobactinnbtABCDEFnfa6190nfa6200StreptomycesavermitilisnocobactinnocobactinnbtABCDEFnfa6190nfa6200nocobactin[](2)NocardiapK18pK19MycobacteriumfortuitumpAL5000NocardiapNV18pNV19Nocardia105/µgDNApK18mobsacBNocardia[](3)NocardiafarcinicaIFM10152P450N.farcinica27P450Nfa33880Nfa53110[](4)NocardiafarcinicaIFM10152N.farcinicaIFM10152HeLaA549J774.1N.farcinicaMycobacteriumtuberculosisN.farcinicaN.farcinica[](5)StreptomycesgriseusIFO13350S.griseus10contigS.griseusStreptomyces120kb[2.(1NocardiafarcinicaIFM10152rpoB2IFM10152RNAβrpoB2N.asteroidesN.farcinicarpoB2[](2)NocardiafarcinicaIFM10152monooxygenaseNocardiafarcinicaIFM10152Rhodococcusequimonooxygenasenfa35380nfa35380nfa35380[](3)MRSAMRSA7-03937-012kbAcc.No.AB24691[](4)MIC32µg/ml45[]VII.(1)[](2)VuTuongVanVanDinkTrangPhungThiBichThuyRealtimePCR[]VIII.(1)4720055462005318220052(2)(3)Trichosporon80Trichosporon7(4)(5)PCRCoccidioidesimmitisC.posadasiireal-timePCRculturecollection(6)Triton-X100[]1.HanaokaN,UmeyamaT,UenoK,UedaK,BeppuT,FugoH,UeharaY,andNiimiM.:Aputativedual-specificproteinphosphataseencodedbyYVH1controlsgrowth,filamentation,andvirulenceinCandidaalbicans.Microbiology,151,2223-2232,2005.ShimokawaO,NiimiM,KikuchiK,SaitoM,KajiwaraH,andYoshidaS.:RelationshipbetweenMICandminimumsterol14α-demethylation-inhibitoryconcentrationasafactorinevaluatingactivitiesofazolesagainstvariousfungalspecies.JournalofClinicalMicrobiology,43,5547-5549,2005.SugitaT,KikuchiK,MakimuraK,UrataK,SomeyaT,KameiK,NiimiM,andUeharaY.:Trichosporonspeciesisolatedfromguanosamplesobtainedfrombat-inhabitedcavesinJapan.AppliedandEnvironmentalMicrobiology,71,7626-7629,2005.LampingE,TanabeK.NiimiM,UeharaY,MonkBC,CannonRD.:CharacterizationoftheSaccharomycescerevisiaesec6-4mutationandtoolstocreateS.cerevisiaestrainscontainingthesec6-4allele.Gene,361,57-66,2005.Igarashi,Y.,Ootsu,K.,Onaka,H.,Fujita,T.,Uehara,Y.andFurumai,T.Anicemycin,anovelantitumorsubstancefromStreptomycesthermoviolaceusTP-A0648.J.Antibitics58:322-326,2005.Hosoya,T.Yamamoto,Y.,Uehara,Y.,Hayashi,M.,Komiyama,K.andIshibashi,M.NewcytotoxicbisindolealkaloidswithproteintyrosinekinaseinhibitoryactivityfromamyxomyceteLycogalaepidendrum.Bioorg.Med.Chem.Lett.15:2776-2780,2005.KimuraH,KatohT,KajimotoT,NodeM,HisakiM,SugimotoY,MajimaT,UeharaY,YamoriT.Modificationofpyrimidinederivativesfromantiviralagentstoantitumoragents.AnticancerRes.26:91-97,2006.Masumi,A.,Aizaki,H.,Suzuki,T.,DuHadaway,L.B.,Prendergast,G.C.,Komuro,K.,Fukazawa,H.:ReductionofHepatitisCvirusNS5AphosphorylationthroughitsinteractionwithamphiphysinII.BiochemBiophysResCommun.336,572-578