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1,2,3,1,4,5(1,610031;2,610041;3,610054;4,610041;5,100080):,,,,,:;;;,,,1999[1],,,,,[2][3],[4],,,,,1111,,,[5,6](PLA)(PGA)(PCL),,,,,[7,8],,PLAPCL,,[9,10](NCA),2;,2NCA22,9018©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[11](PEG),2,2NCA,22,[12],2NCA,2,,,[13,14]3252,,3252,52,252,PLAPCLPEGLi22(PECL)[15]Bogdanov,PEGPECL[16],PECL[17],,PECL[18,19],[20,21],,2[2225]222[26,27],,2,Stapert,,,,[28]112(PPDO),FDA[29]PPDO,-10,110,140165[30]2,PPDOPLAPGA,PPDO,500%600%,7000Psi;PCL,PPDO,6,PCL[31],PPDO,PDO,,,,PDO,PPDO[32]PPDOPDOPPDO,,,[33][34]PPDO,[35][36][37],,,,Schultz,,2183dLPg(1,1,2,22,25,015gPdL[38])PPDONewman,,213810dLPg(,25,011gPdL)PPDO[39]PDO,,,P,310dLPg(P1,1,2,22,25,011gPdL[40])PPDO;01120088©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(P1,1,2,22,25,011gPdL)PPDO,PDO(LA)(GA)2(CL)(TMC),,[4144],Raquez,CLPDO,P(CL2b2PDO)[45]PPDO,PPDO,[46]PPDO,PDO,[47],[48]PPDO,PDO,,113,,1969,,,[49],(PPC)(PCHC)[50],[51](PBS),,,PBS,PBS,,;,,(:),IshiiCHTD(12chloro232hydroxy21,1,3,32tetrabutyldistannoxane)PBS,2717[52],,,,,PBS[53]2211,,[54,55],,2,,Rathi(2)(PLGA)APEGBABABAB,,3035,4070[56],2[57],ReGel@,200h50[58]1118©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[59]ABABAB[56](AB)n[60][61,62][63],PLAPLGAPCL[6467](22)(22)(22),21PDO,2[6872]-,,,,,,,,,,,[73],,22,[74,75],()(),[76],,,,,,;,,,,,,;,,,;,,,,,1P(LA2CL)2PEG2P(LA2CL)2Figure1Thesol2geltransitionbehaviorsoftriblockcopolymerP(LA2CL)2PEG2P(LA2CL)212,,,,,Langer2002,,,,[77]2005Lendlein,,[78]2005,PLA(2)2L2221120088©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(P)[79]2005,[80]2006(2),,[81,82]2(3P1)Figure2TheshapechangesofPDLLAPHA3311,[83],,,(),,,,,,[84],:PLAPGAPLGA222[85]2DL22(PELA)(HSA)(TCP)(OMP)(Vi)(HBsAg)(3a),[86],,,2,[87]PLGA,[88,89],TCPOMP,,[90,91],,,50%[92],,,[93],[94](3b)[95,96],[97],011510m3118©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[98],125IOMP,[99],,,,,,,,[100,101],2,[102],,DNA,DNADNA,,,,DNA[103,104],,,,[105],(3c),[106]3(a)(b)(c)Figure3Themorphologies(a)andinvitroproteinreleaseprofiles(b)ofbiodegradablepolymericmicrospheres,andthemorphologiesofelectrospunpolymericfibers(c).31260,,70,,1987,,,,,,2[107],,,,,[108],[108],,41120088©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[109],,,,,[110],(4a),,,,[111],,,,[112][113],P,[114,115],,,,HA,[116]HAHA,HA,PDLLA(4b)[117],HA,,,,2,,[118121]4(a)PLAPHA(b)Figure4Thecellgrowthbehaviorsoffibroblastonelectrospunfibrousmats(a)andthePLAPHAfibrouscompositescaffoldsgrowninsitu(b)4,CargillDow,23,5,70%,,,,50%,5118©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.()CargillDow200050,,40CollegeFarmR2004,(),,,,2005,Monte2004WildOats,AveryDennisonBiota2004,Delhaize2005,,NNZOkopackR,,412,,,,,,,,,,CargillDowCargillDowIngeoRSoronaR,,,,34,,TPlastarchR,,,413NEC61120088©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(HycailXMR1020)200,,20530h,,5511,,,,20%,,,,CargillDow,(),100P,,,Sehan,850Gumi5PPLA,20071,5P,UhdeInventa2Fischer215P,Hycail21515P,2010,UhdeInventaFischer1P,(5P),512(PBS)PBS,,20063,2PBS,1000(PHA)(2P),,Novamont(Mater2biR),,(8P)(8P)(5P)(2P)(5P)7118©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:12,,,PCLPPDO,3,1984Rokkanen(),L2PLA,PLAPLAPLAPLA,PLA1002300,,,PLGA,,,,[122]PLA,[123],,,PLA[124],,,,PLAPLGA(75P25)PLGA(50P50),11(LupronDepotREnantoneDepotR)(EligardR)(TrelstarDepotRDecapeptylR)(ProfactDepotR)(ZoladexR),Somatropin(NutropinDepotR)(SandostatinLARR),Alkermes,,,,AmgenGenentechIsisTherapeuticsPLAPLGA,PLGA,,,80,FDA,IntegraR1981,62,,,1997OrganogenesisApligrfR,,AdvanceTissueSciencesDermagraftRTransCyteR,,,2007,,81120088©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:,(2870264290702112943402039470653594730092977403429934062200040095030301830570501506030255077306520774075)863(THC297061)973(G1999064703):[1],,,.,1999,(1):2432.[2]GunatillakeP,MayadunneR,AdhikariR.BiotechAnnuRev,2006,12:310347.[3]NairaLS,LaurencinCT.ProgPolymSci,2007,32:762798.[4]Martina1M,HutmacherDW.PolymInt,2007,56:145157.[5]OkadaM.ProgPolymSci,2002,27:87133.[6]GuptaAP,KumarV.EurPolymJ,2007,43:40534074.[7]GottschalkC,FreyH.Macromolecules,2006,39:17191723.[8]OuchiT,OhyaY.JPolymSci,PolymChem,2004,42:453462.[9]LiuY,YuanML,DengXM.EurPolymJ,2003,39:977983.[10]DengXM,LiuY,YuanML.EurPolymJ,2002,38:14351441.[11]YuanML,WangYH,LiXH,etal.Macromolecules,2000,33(5):16131617.[12]YuanML,DengXM.EurPolymJ,2001,37:19071912.[13]YuanML,LiXH,LiuYL,etal.MacromolChemPhys,2001,202(4):546552.[14]DengXM,YaoJR,YuanML,etal.MacromolChemPhys,2000,201(17):23712376.[15]PetrovaT,ManolovaN,RashkovI,etal.PolymInt,1998,43:419426.[16]Bogda