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1,2(1.,100037;2.,065000),,,;;;Q24A0517-6611(2007)24-07418-02TheDatabasesofEukaryoticPromotersandRelatedSoftwareResourcesLIUYu2yingetal(CollegeofLifeScience,CapitalNormalUniversity,Beijing100037)AbstractEukaryoticpromotersareimportantelementsinregulationoftheexpression.Tostudythestructureandfunctionofapromoterdeeply,itisthekeytoknowhowthegeneregulatesitstranscriptionandstartsitsexpression.Withthefastdevelopmentofbiologicalandcomputertechnology,significantachievementshavebeenmadeincomputationalpredictiononEukaryoticpromoters.InthispapermainlyintroducestheprogressmadeinthedatabasesofpredictingEukaryoticpromotersaswellastherelatedsoftwareresourceswasintroduced.KeywordsWikipedia;Promoter;Database;Prediction,,,,13,RNADNA-25-307bp,:T85A97T93A85A263A83A50,TATAGoldberg2Hogness,,,TATATATAATAAAAATGTAA,80%CAATGC,,CAATGGCT2CAATCT,-75-80,CTFCP1CP2NF21;GCGTGGGCGGGGCAAT,-90,Sp1,,CAAT,,cAMP(1982-),,,,:2007204223,22.1EPD(Eukaryoticpromoterdatabase)[1]EPD(://ftp.epd.isb2sib.ch/pub/databases/epd)RNAII1500,,:RNA,EPDEMBLSWISS2PROTTRANSFAC,(76),EPD6:,2997,1871,62%EPD,2.2PLACE(Plantcis2actingregulatoryDNAelements)[2]PLACE(://ftp.dna.affrc.go.jp/)(motifdatabase),1991PLACE,,PLACEPubMed,DDBJ/EMBL/GenBank,PLACE,SRS()PLACE,,FASTA,JournalofAnhuiAgri.Sci.2007,35(24):7418-74192.3TRRD(Transcriptionregulatoryregionsdatabase)[3]TRRD(),,,20016.038981167,5537,1714,145335TRRD,5:TRRDGENES(TRRD);TRRDSITES();TRRDFACTORS(TRRD);TRRDEXP();TRRDBIB()TR2RD,2:(SRS),TRRD;TRRDViewer,2.4TRANSFAC(Transcriptionalregulation,frompatternstoprofiles)[4]TRANSFAC(://transfac.gbf.de/TRANSFAC/),TRANSFAC6:SITE,GENE,FACTOR,CELL,CLASS,MATRIX,TRANSFAC:PATHODB;S/MARTDB;TRANSPATH;CYTOMER3,,,:,,;,,;,,;cDNAEST,5,,;,[5],,,[1]CHRISTOPHD,VIVIANEP.TheEukaryoticpromoterdatabaseEPD:theimpactofinsilicoprimerextension[J].NucleicAcidsResearch,2004,32:82-85.[2]KENICHIH,YOSHIHIROU.Plantcis2actingregulatoryDNAelements(PLACE)database:1999[J].NucleicAcidsResearch,1999,27(1):297-300.[3]KOLCHANOVNA,LGNATIEVAEV.Transcriptionregulatoryregionsdatabase(TRRD):itsstatusin2002[J].NucleicAcidsResearch,2002,30(1):312-317.[4]MATYSV,FRICKEE.TRANSFAC:transcriptionalregulation,frompatternstoprofiles[J].NucleicAcidsResearch,2003,31(1):374-378.[5]TOMPAM,LIN,BAILEYTL,etal.Assessingcomputationaltoolsforthedis2coveryoftranscriptionfactorbindingsites[J].NatureBiotech,2006,23:137-144.(7417)DNAAFLP428191DNA,428191,AFLP4189,98.9%,98.9%,,AFLP,,Jaramillo3(clades):,[10],,1234561,,[1],,,.AFLP[J].,2006,39(11):2194-2199.[2],,,.AFLP[J].,2006,26(5):927-932.[3],,,.()AFLP[J].,2006,28(1):85-90.[4],,,.AFLP[J].,2006,33(2):317-322.[5],.RAPDAFLP[J].,2006,18(2):1-4.[6].[D].:,2004.[7],,,.RAPD[J].,2005,15(6):34-37.[8].SSR[D].:,2003.[9]NEIM,LIWH.Mathematicalmodelforstudyinggeneticvariationintermsofre2strictionendonucleases[J].ProcNatlAcadSciUSA,1979,76:5269-5273.[10]JARAMILLOMA,MANOSPS.PhylogenyandpatternsoffloraldiversityinthegenusPiper(Piperaceae)[J].AmJBot,2001,88(4):706-716.91473524