GG1.1.2.2.112277GGGGcAMPcAMPGTP-G(GTPbindingprotein)1.G,2.3.GTPGTPGDPGTPGDP()cAMPATPGsGicAMPcAMP5’-cAMP1.1.(endocrine):(endocrine):2.2.((paracrineparacrine):):3.3.((autocrineautocrine):):OIHOINH2II-CH2-CH-COOH-CH2-CH-COOHIINH2HOIO.HOHOCHCH2OHNHCH3HOHOCHCH2OHNH2CCHHONHCH3HCH3CCOHHNHCH3HCH31R,2S-(-)-()1S,2S-(+)-()2αβδαβHis-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asp-ThrOCOHOCH2OHOH⎯COOHOOHOHPGE1PGF1aCOOHOHOHOHPGE2COOHOOHOHCOOHOHOHOHPGF2aCOOHOOHOHPGE3PGF2aCOOHOHOHOHOHOHOHOHOPOPOPOP4ATP4ADP4H2O4PiβββCH2NH2CH2CH2CF2CHCOOHNH2NCHOCH2OPO32-HOCH3NCCH2OPO32-HOCH3CH2NH2CH2CH2CCHCNOO-FFNCCH2OPO32-HOCH3CH2NH2CH2CH2CNCHF:NuEnZCH2NH2CH2CH2CCHF:NuEnZNHCHNCH2OPO32-HOCH3H——————…°°υ…υ…υ…π———……—°+βCOOHOCOCH3celecoxib