17320820096ChinJIntegrTradWestMedDigVol.17No.3P.208Jun.2009:2009203221:16712038X(2009)0320208203(2008),,,,,():,;:R575.5;R22031:A1(NAFLD),(NASH),2222,25%,,,,,,,,3NAFLD,,,,()44.1NAFLD,1567NAFLD:140g,70g;;,;();2(GGT)(5),(ALT);;4.2,NAFLDNASHNASH1234:13;;;1314NASH:13;ALT4;;NASH,,1234NASH:13;();;,NASH2006;NAFLD22;NAFLD40g140g,70g;NAFLD;;NASHNASH(NASH)NASH;NAFLD(ALD),;,55.1:;;;:;;;:,,:,2125.2:;;;:;;;:,,,,:,2125.3:,;;;:;;;:,,:,2125.4:,;;;:;;;:,,,,:,2125.5:;;;:;;;:,,,,,:,2126:;2,B:,2;1;(1;2)CT:CT1(0.70.70.5),2(0.5),:0,1,2::N=(-)/100%:70%N90%;:30%N70%;:N30%:BCT2,8;3,6,37,,,7.1,,,,,,,,,,,7.27.2.1,:,::,:,:,,:,,:,,:,:,,:,,:,7.2.1NAFLD,,,NASH,(),7.2.3,,902,.(2008),,,,1.5,,,,,,;,;,;,,67,30min,1,1517.3,,:,,()():,(),,,,ALT(),,,,,():,,,,,,LDL/HDL,,()():NASH,NAFLD,,,,,,,()()()(207)[15]SHIMIZUK,KUBOH,YAMAGUCHIK,etal.Sup2pressionofVEGFR23signalinginhibitslymphnodemetastasisingastriccancer[J].CancerSci,2004,95:328-333.[16],,,.VEGF2C[J].,2007,34(8):437-440.[17]PARTANENTA,AROLAJ,SAARISTOA,etal.VEGF2CandVEGF2Dexpressioninneuroendocrinecellsandtheirreceptor,VEGFR23,infenestratedbloodvesselsinhumantissues[J].FASEBJ,2000,14:2087-2096.[18]NATHANSONSD,ZARBORJ,WACHNADL,etal.Microvesselsthatpredictaxillarylymphnodeme2tastasesinpatientswithbreastcancer[J].ArchSurg,2000,135:586-593.[19]DIASS,CHOYM,ALITALOK,etal.Vascularendo2thelialgrowthfactor(VEGF)2CsignalingthroughFLT24(VEGFR23)mediatesleukemiccellprolifera2tion,survival,andresistancetochemotherapy[J].Blood,2002,99:2179-2184.[20]WITMERAN,VANBLIJSWIJKBC,DAIJ,etal.VEGFR23inadultangiogenesis[J].JPathol,2001,195:490-497.[21],,,.22[J].,2005,8(4):348-351.[22],,,.222C[J].,2004,43(11):841-844.[23],,,.COX22VEGF2C[J].,2005,32(11):607-610.[24],,,.2C[J].,2005,25(7):413-416.[25],,,.VEGF2CMMP22[J].,2006,15(4):329-331.[26],,,.nm23H1mRNAVEGF2CmRNA[J].,2006,39(1):46-54.[27],,.CD44V62C[J].,2005,(137):14797-14798.[28]TAKAHASHIA,KONOK,ITAKURAJ,etal.Cor2relationofvascularendothelialgrowthfactor2Cexpres2sionwithtumor2infiltratingdendriticcellsingastriccancer[J].Oncology,2002,62:121-127.[29]KITADAIY,KODAMAM,CHOS,etal.Quantitativeanalysisoflymphangiogenicmarkersforpredictingme2tastasisofhumangastriccarcinomatolymphnodes[J].IntJCancer,2005,115:388-392.[30]TSUTSUMIS,KUWANOH,SHIMURAT,etal.VascularendothelialgrowthfactorC(VEGF2C)ex2pressioninpT2gastriccancer[J].Hepatogastroenter2ology,2005,52:629-632.01220096173