德国美剂乐药用乳糖

CN09/08Pe’5SaiPresentedbyMEGGLEMEGGLEGroupWasserburgBGExcipients&TechnologyMegglestraße6–1283512WasserburgGermany+49-(0)8071-73-476+49-(0)[e-mail]ße6–1283512WasserburgGermany+49-(0)8071-73-476+49-(0)[e-mail]®40InhaLac®70InhaLac®120InhaLac®230CapsuLac®60SacheLac®80SpheroLac®100GranuLac®70GranuLac®140GranuLac®200GranuLac®230SorboLac®400Tablettose®70Tablettose®80Tablettose®100FlowLac®100Cellactose®80MicroceLac®100StarLac®MEGGLEFlowLac®9067733MEGGLE467810121416182022242626Cellactose®8028MicroceLac®10030StarLac®323435788PrismaLac®40CapsuLac®60SacheLac®80SpheroLac®100Ph.Eur.–USP-NF–JP8995045403530252015105001020304050607080PrismaLac®40CapsuLac®60SacheLac®803214PrismaLac®40CapsuLac®60SacheLac®80SpheroLac®10063µm≤20%/9%100µm≤10%/5%≤20%/5%150µm/15%/78%200µm≤10%/4%≥75%/98%250µm40–70%/60%/63%/99.5%400µm≥90%/99%≥98%/100%500µm/65%630µm/90.5%≥97%/100%800µm≥97%/100%[g/l]/470/590/600/690[g/l]/540/700/710/84091010Ph.Eur.–USP-NF–JPPrismaLac®40500µm500500500500µmµmµmµmPrismaLac®40(%)100908070605040302010001002003004005006007008009001000(µm)CapsuLac®60CapsuLac®60(%)100908070605040302010001002003004005006007008009001000(µm)1011500µm5005005005000µmµmµmSacheLac®80SacheLac®80(%)10090807060504030201000100200300400500(µm)SpheroLac®100SpheroLac®100(%)10090807060504030201000100200300400500(µm)111212InhaLac®70InhaLac®120InhaLac®230Ph.Eur.–USP-NF–JP1213135045403530252015105001020304050607080InhaLac®70[1]InhaLac®120[1]InhaLac®230[2]321[1]4[2]6InhaLac®70InhaLac®120InhaLac®230d10110µm90µm45µmd50200µm130µm90µmd90300µm190µm135µm[g/l]590700710[g/l]660790820Hausner1.11.131.15InhaLac®InhaLac®InhaLacInhaLa®InhaLac®131414500µmInhaLac®70InhaLac®70(%)(%)1002090188016701460125010408306204102000101001000(µm)Ph.Eur.–USP-NF–JP1415500µm500µmInhaLac®120InhaLac®120(%)(%)10030908070605040302010000101001000(µm)InhaLac®230InhaLac®230(%)(%)100259080207060155040103020510000101001000(µm)252015105151616GranuLac®70GranuLac®140GranuLac®200GranuLac®230SorboLac®400Ph.Eur.–USP-NF–JP161717GranuLac®70GranuLac®140GranuLac®200GranuLac®230SorboLac®40032µm≤40%/30%45–75%/55%/75%≥90%/97.5%63µm≥90%/96%/99.5%100µm40–60%/50%≥80%/90%≥90%/98.4%/99.5%400µm≥95%/99.5%630µm/100%[g/l]/715/660/535/465/390[g/l]/900/890/800/760/630GranuLac®SorboLac®400171818GranuLac®70100µmGranuLac®70(%)10090807060504030201000100200300400500600700(µm)GranuLac®140GranuLac®140(%)10090807060504030201000100200300400500(µm)200µmGranuLac®200GranuLac®200(%)10090807060504030201000100200300400500(µm)200µmPh.Eur.–USP-NF–JP181919GranuLac®230GranuLac®23010090807060504030201000100200300400500(µm)SorboLac®400SorboLac®40010090807060504030201000100200300400500(µm)2002002002000µmµmµmµmµ100100100100µmµmµmm1920202021MEGGLEMEGGLECellactose®80MicroceLac®100StarLac®MEGGLE20MEGGLEMEGGLEMEGGLEMEGGLE212222Ph.Eur.–USP-NF–JPTablettose®70Tablettose®80Tablettose®100DirectCompression60555045403530252015105001020304050607080Tablettose®70Tablettose®80Tablettose®1003214222323Tablettose®70Tablettose®80Tablettose®10063µm≤6%/3%≤20%/13%≤25%/12%150µm/25%/42%180µm40–75%/53%200µm30–70%/56%250µm60–90%/77%400µm/93%≥85%/93%500µm≥98%/100%≥96%/100%630µm≥97%/100%[g/l]/548/610/570[g/l]/670/738/690(N)250200150100500050100150200250300(MPa)Tablettose®70Tablettose®80Tablettose®100KorschEK0∅8mm,240mgTablettose®70/80/100αTablettose®Tablettose®70Tablettose®70/80/100232424Ph.Eur.–USP-NF–JPTablettose®70Tablettose®70(%)10090807060504030201000100200300400500600700(µm)500µm242525500µmTablettose®80Tablettose®80(%)10090807060504030201000100200300400500600700(µm)Tablettose®100Tablettose®100(%)10090807060504030201000100200300400500600700(µm)200µm252626Ph.Eur.–USP-NF–JPFlowLac®90FlowLac®100DirectCompressionFlowLac®90FlowLac®10032µm≤5%/2%≤10%/5%100µm25–40%/30%20–45%/34%200µm≥85%/92%≥80%/88%250µm/99%/98%[g/l]/600/620[g/l]/660/710FlowLac®90FlowLac®90FlowLac®90FlowLac®90FlowLac®100FlowLac®100FlowLac®100FlowLac®90FlowLac®90FlowLac®100262727555045403530252015105001020304050607080FlowLac®90FlowLac®100321,4300µm500µmFlowLac®90FlowLac®90(%)10090807060504030201000100200300400500(µm)FlowLac®100FlowLac®100(%)10090807060504030201000100200300400500(µm)(N)300250200150100500050100150200250300(MPa)FlowLac®90FlowLac®100KorschEK0,∅8mm,240mgFlowLac®100272828Cellactose®80Cellactose®8075%α25%DMFDirectCompressionCellactose®8032µm≤20%/9%160µm35–65%/56%250µm≥80%/95%[g/l]/380[g/l]/500Cellactose®80403530252015105001020304050607080Cellactose®80321,4282929Cellactose®80(%)10090807060504030201000