57抗高血压药物毕业论文

学号：200814230222HEBEIUNITEDUNIVERSITY毕业论文GRADUATETHESIS设计题目：三河市优抚医院抗血压药物的临床应用研究学生姓名：郭晓双专业班级：08药物制剂学院：药学院指导教师：刘江群主任医师2012年05月28日摘要I摘要目的：研究三河市优抚医院抗高血压药物的临床应用情况，分析门诊抗高血压药物之间相互应用的合理性，为临床合理用药提供参考。方法：利用本院信息查询软件和药品库存管理系统，从我院门诊2012年3月处方中筛选出含有抗高血压药物的处方452份，统计分析患者性别、年龄、各类抗高血压药物的用药频度（DDDs）、及药物联合应用情况。结果：以老年患者为主，男性略高于女性。钙离子通道拮抗药（CCB）与血管紧张素转化酶抑制剂（ACEI）的使用频次最高。联合用药方案较合理，共有处方202张，占44.9%。其中以二联用药最多，共161张，占35.8%。结论：三河市优抚医院抗高血压药物的应用基本符合《中国高血压防治指南》。大部分联合用药方案较合理，但缺乏对联合用药提高血压达标率的认识。抗高血压药物品种繁多，选择安全、有效、经济、合理的药物至关重要。关键词高血压病；抗高血压药物；临床应用AbstractIIAbstractObjective:ToresearchantihypertensivedrugsusinginSanHeCityHelpingHospital.AnalysistherationalityofoutpatientantihypertensivedrugsapplicationatOutpatientservice,inordertoprovideareferenceforclinicalmedication.Methods:Usingtheinformationquerysoftwareanddruginventorymanagementsystem,wefilter452piecesdrugprescriptionsthaeincludesantihypertensivedrugsfromourhospitaloutpatientserviceofMarch2012,tosumupandanalyzepatients’gender,ageandDefinedDailyDoseSystem(DDDs)ofallkindsoftheantihypertensivedrugandthedrugjointapplication.Results:Mostofthepatientsareelderpeopleandthemalesslightlyhigherthanthefemales,CalciumChannelBlocker(CCB)andAngiotensinConvertingEnzymeInhibitors(ACEI)isusingthemostfrequently.Thedrugcombinationschemeismorereasonable,andhas202piecesprescriptions,accountsfor44.9%,amongittwo-drugtakethemostpercent,accountsfor35.8%.Conclusion:TheapplicationoftheantihypertensivedrugofSanHeCityHelpingHospitalbasicallyinlinewiththe“China'shighbloodpressurecontrolguidelines”Mostcombinationschemearemorereasonable,butarelackoftheconsciousnessaboutthedrugcombinationcanrisethecontrolrateofbloodpressure.Therearemanykindsofantihypertensivemedicine,soitisveryimportanttochoosethesafely,effectiveanseconomicalmedicineKeywordsHypertension;Antihypertensivedrugs;Clinicalapplication目录III目录摘要.............................................................................................................................IABSTRACT..................................................................................................................II第1章绪论..............................................................................................................1第2章资料和方法......................................................................................................22.1数据来源.............................................................................................................22.2药物分类.............................................................................................................22.3方法.....................................................................................................................22.3.1统计患者性别年龄分布...............................................................................22.3.2计算各类抗高血压药物的DDDS值...........................................................22.3.3联合用药情况................................................................................................2第3章研究结果..........................................................................................................33.1基本情况.............................................................................................................33.2各类抗高血压代表药的DDDS排序.................................................................33.3药物的联合应用情况.........................................................................................3第4章讨论..................................................................................................................54.1高血压患者的性别及年龄.................................................................................54.2各类抗高血压药物应用情况.............................................................................54.3抗高血压药物的联合应用及评价.....................................................................64.3.1CCB和ARB的联用.....................................................................................64.3.2CCB和ACEI的联用....................................................................................74.3.3ARB与利尿药的联用...................................................................................74.3.4Β-RB与ACEI的联用...................................................................................74.3.5Β-RB与CCB联用........................................................................................7结论............................................................................................................................8参考文献........................................................................................................................9谢辞..........................................................................................................................10注释..........................................................................................................................11附录..........................................................................................................................12第1章绪论1第1章绪论高血压是心血管疾病中常见病，近年来，随着人们生活水平的提高和生活方式的改变，高血压病的发生率呈逐年上升的趋势[1]，已从1980年的7.73％、1991年的11.88％上升到2008年的18.8%，患病人数为1