甜菜碱的功能

NaturalBetaineandItsHealthBenefits天然甜菜碱：赋予产品更多健康概念的新功效成分1Applyname/department/presentationtitlein'headerandfooter'2内容提要天然甜菜碱及其主要生理功能及健康功效甜菜碱在护肝、及体能表现方面的作用应用天然甜菜碱的新品举例总结Applyname/department/presentationtitlein'headerandfooter'3WhatisBetafin®BF?什么是天然甜菜碱？Minimum99%purebetaineanhydrous最少99%无水纯天然甜菜碱SometimesalsocalledTMG(trimethylglycine)也称三甲基甘氨酸Extractedfromsugarbeetmolasses,100%naturalproductwithnoaddedchemicals来自于甜菜糖蜜，是百分百天然的产品Naturallyexistsinalllivingmaterial;bothsynthesizedinthebodyandingestedinfoods天然存在于生物体，人体可自身合成并可由食物摄入Richsourcesincludespinach,wheat,seafood,beets富含的食物包括菠菜、大麦、海产品、甜菜等Betainewidelyusedforover25yearsinanimalfeedsandnaturalcosmeticsproducts甜菜碱应用于饲料及化妆品已有超过25年的历史LonghistoricaluseinJapanasaflavorcompoundinimitatedseafoodproducts长久以来甜菜碱被用作模拟海产品风味的香原料3Applyname/department/presentationtitlein'headerandfooter'4Sugarbeet甜菜(0.2-0.3%betaine)SugarbeetplantMolasses糖蜜(3-6%betaine)SugarPulpChromatographicseparation色谱分离(patentedDaniscotechnology丹尼斯克专利)Betaine甜菜碱Methyldonor,Osmoprotectant甲基供体；渗透保护剂Animalnutritionandhealth动物营养与健康Food食品Fermentation发酵CosmeticsandPharmaceuticals化妆品及药品（保健品）Sugar糖MethyldonorBipolarelectrolytePlant植物BetaineProductionandApplications天然甜菜碱的生产及应用Applyname/department/presentationtitlein'headerandfooter'5Osmolyte3methylgroupsNCCCCCOOHHHHHHHHHHH+-TheStructureofBetaine甜菜碱的化学结构5三个甲基渗透压调节剂Applyname/department/presentationtitlein'headerandfooter'6Betaine:TwoKeyBiochemicalRoles甜菜碱在人体中的两个重要生化功能Osmolyte渗透压调节剂:Protectsagainstdehydrationandothertypesofstress甜菜碱是最有效的渗透压调节剂，可以帮助保持细胞水分平衡甜菜碱同时也可以保护细胞的酶不受由于水分流失及有害物质带来的危害MethylDonor甲基供体:Importantinmanycellularfunctions甲基基团参与多过100个与维持肌体及细胞正常功能相关的反应这些反应包括DNA、RNA、神经传输物质等的合成，及启动解毒反应HumanClinicalStudies人体临床研究:•Protectinternalorgans(heart,liver,kidney)保护内脏器官•Improvevascularriskfactors(particularlyserumhomocysteine)改善与血管疾病相关危险因子的水平•Enhancephysicalperformance增强体能Applyname/department/presentationtitlein'headerandfooter'7HealthBenefitsofNaturalBetaine天然甜菜碱的健康功能Liverprotectionfunction护肝功能Homocysteinelowering降低同型半胱胺酸Betaineisshownbyseveralclinicaltrialstolowerbloodhomocysteinelevels一些临床试验显示甜菜碱能降低血中同型半胱胺酸的水平Highhomocysteineiswidelyconsideredasanindependentriskfactorforcardiovasculardiseases高同型半胱胺酸被广泛认为是一个导致心血管病的独立的危险因素BetaineusedoftenincombinationwithvitaminsB6,B12andfolicacid甜菜碱经常与维生素B6、B12和叶酸辅配在一起用。Sportsperformance运动表现Betaineisshowninclinicaltrialstosignificantlyimprovestrengthandpowerduringexercise临床验证表明甜菜碱能显著提高运动中的力量表现。Positivebenefitsforathletesandactivepeoplewantingtoimprovetheirperformance对运动员们有正面的帮助，也能提高普通人在运动中的表现Oralhealth口腔健康Betaineisshowntohaveapositiveeffectonmoisturizingthetissueandcellsliningthemouth(mucuousmembrane)甜菜碱显示可以有效润湿口腔内组织及细胞Especiallyforpeoplesufferingfromdrymouthproblems特别是对于口干症患者E.g.inproductslikelozenges,chewinggum,hardcandy可应用于止咳糖，口香糖和硬糖。7Applyname/department/presentationtitlein'headerandfooter'8WhyisLiverHealthsoImportant?为什么肝脏的健康很重要？Thelargestglandinthebody人体最大腺体Thesecondlargestorganinthebody人体第二大器官Importanttocarbohydratemetabolism,lipidmetabolismandproteinmetabolism对糖代谢，蛋白质的新陈代谢及脂肪代谢十分重要Themainsitefortransmethylationreactions甲基化反应的主要场所Livercellsaremetabolicallymostactivecellsinthebody最活跃细胞Excessammoniainthebloodcausesfatigue血中过高的氨会引起疲劳Imbalanceinglycogenstorageanddepletioncausesbloodsugarlevelfluctuation糖原的不平衡及过度损耗将引起血糖波动Risksassociatedwithtoxicbuildup毒素堆积Potentialeffectsonskinandotherorgans对皮肤和其它器官有间接影响GOODLIVERHEALTHHASASIGNIFICANTEFFECTONOVERALLHEALTHANDWELLBEING肝脏的健康对整个身体的健康和生存有很大的影响。8Applyname/department/presentationtitlein'headerandfooter'90200040006000800010000Fat脂肪红血球肌肉Plasma血浆Colon结肠十二指肠Kidney肾脏Liver肝脏Radioactivity(dpm/gtissue)*FateofDietaryBetaineintheBody甜菜碱在各器官的分布*Radioactivity(dpm/gtissue)ofbroilerchicktissues24hoursafteroraladministrationoflabelledbetaineApplyname/department/presentationtitlein'headerandfooter'10WhatisFattyLiver?什么是脂肪肝？Fattyliver(steatosis)istheaccumulationofextrafatinthelivercells脂肪在肝脏的过度堆积Fattyliverisnormallydiagnosedbyliverfunctiontests(ALT,AST,GGT)frombloodsamplesandultrasoundorCT(computerizedtomography)scanorMRI(magneticresonanceimaging)可通过血液化验、超声、CT、核磁共振诊断Therecentandgrowingincidenceoffattyliverandassociatedliverdiseasesismainlycausedbytoday’slifestyle;Westerndiet,reducedexerciseandalcoholconsumption近期脂肪肝及肝脏疾病上升跟现在的生活方式有关包括西方的膳食，运动的减少及饮酒Longertermandlargerfataccumulationmayleadtoliverinflammation(steatohepatitis)andfurthertoseriousliverdiseases(fibrosisandcirrhosis)长期及大量的脂肪堆积会导致肝炎，并会发展成更严重的肝脏病变如纤维化及肝硬化。10Applyname/department/presentationtitlein'headerandfooter'11FattyLiverDiseaseCanBeCausedby脂肪肝的引起有以下原因Metabolicfat代谢性肥胖(obesity,hormones,diabetes)Hepatotoxins肝毒素(ethanol乙醇,carbontetrachloride四氯化碳)Toolowprotein/energyratiointhediet膳食中蛋白质/能量比例太低11Applyname/department/presentationtitlein'headerandfooter'12Non-alcoholicFattyLiverDiseases非酒精性的脂肪肝Non-alcoholicfattyliverdisease(NAFLD)affects1:非酒精性脂肪肝会影响~20%ofthegeneralglobalpopulation全球大约20%的人口~50%ofdiabetics大约50%的糖尿病患者50%ofobesepersons大约50%的肥胖者~90%ofmorbidlyobesepersons90%的病态肥胖者“NAFLDisthehepaticmanifestationofthemetabolicsy