复方皂矾丸防治吉西他滨加顺铂方案化疗所致血小板下降的临床观察

·80·2010472ChineseJournalofDrugApplicationandMonitoring,Vol.7,No.2,April2010[1-2][3]11.120076–20095100853[]39201911.0g·m-2d1d825mg·m-2d1-31.6g38d14d14dP0.05[][]R969.4[]A[]1672–8157(2010)02–0080–02EffectobservationofcomplexZaofanpillonpreventingplateletdepressioncausedbygemcitabineandcisplatincombinationchemotherapyZHANGYin,CAOKe,FENGYu,WANGHai-ming,HETing-ting(TraditionalChineseMedicineInstituteofPLAGeneralHospital,Beijing100853,China)[ABSTRACT]Objective:ToobservetheeffectofcomplexZaofanpillonpreventingplateletdepressioncausedbygemcitabineandcisplatin(GP)combinationchemotherapy.Methods:Thirty-ninecancerpatientsreceivingGPcombinationchemotherapyfor1cycleweredividedintotreatmentgroup(20cases)andcontrolgroup(19cases).Twogroupswereallintravenouslytreatedwithgemcitabine1.0g·m-2forthefirstandeighthdayandcisplatin25mg·m-2forthefirstthreedays.Atthesametime,thetreatmentgroupwasalsoorallytreatedwithcomplexZaofanpill1.6gthreetimesadayfor8days.WhilethecontrolgroupwastreatedwithGPchemotherapyonly.Theoccurrenceofplateletdepressionandthetotalplateletcountwereevaluatedafterthechemotherapyfor14days.Results:Theextentofplateletdepressionwaslowerintreatmentgroupthanincontrolgroupandthetotalplateletcountwashigherintreatmentgroupthanincontrolgroupafterthechemotherapyfor14days,whichshowedsignificantdifferencebetweentwogroups(P0.05).Conclusion:ComplexZaofanpillcanlightentheplateletdepressioncausedbyGPcombinationchemotherapy.[KEYWORDS]ComplexZaofanpill;Chemotherapy;Bonemarrowdepression;Thrombocytopenia42604109·L-11.5109·L-1100109·L-1213127392012836~73a51.48.2a1551913639~74a52.19.0a1542P0.05[][e-mail]2010472ChineseJournalofDrugApplicationandMonitoring,Vol.7,No.2,April2010·81·1.221.0g·m-2d1d825mg·m-2d1-311.6g38d1.3WHO11.4SPSS12.0t22.121420.0%4/2057.9%11/192P0.0522.221414P0.0532.32231273[4-5][6]P0.05217P0.05[][1].[J].2008212124-126.[2].36[J].2007274625-626.[3].[J].2007364391-395.[4].[M].20031097.[5].[M].2002258-259.[6].[J].2004156387-389.2009-08-032009-11-201Tab1Classificationoftoxicandadversereactionofantitumordrugs0/109·L-14.03.0~3.92.0~2.91.0~1.91.0/109·L-12.01.5~1.91.0~1.40.5~0.90.5/g·L-1110.095.0~100.080.0~94.065.0~79.065.0/109·L-1100.075.0~99.050.0~74.025.0~49.025.02214.(%)Tab2Comparisonoftheextentofplateletdepressionafterchemotherapyfor14daysbetweentwogroups.case(%)19631.6315.8210.500.020315.015.000.000.03214.109·L-1,xsTab3Comparisonoftheplateletcountbeforeandafterchemotherapyfor14days.109·L-1,xs1419205.233.187.641.3116.843.520198.331.898.832.698.233.1**P0.05Note:Comparedwiththecontrolgroup,*P0.05