天津中医药行业产学研合作发展的几点思考

2004-09-14CS0041961-1009-5276200503-0479-02300193R931AFDA1.2.3.4.5.1.2.3.1.23320053CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEVol.23No.3Mar.20054792.3.1.2.3.1.J.2001154～59478123451.1987731292.J.19999429～303.J.19907124～274.-M.============================================2001.268～270453AbstractObjectiveTostudytheeffectsofpolysaccharidesfromndhyphaeasporesofAgaricusbaizeiMurillontheproliferationofthegastricadnocaccinomaSGC-7901cells.MethodsThecloneformationmethodMTTassayandgrowthcurvewereadoptedtoab-servetheeffectontheproliferationoftheSGC-7901cells.ResultsComparedwithcontrolgroupstheMTTformazanandcloneforma-tionofthegastricadnocaccinomaSGC-7901cellsweredecreasedsignificantlyP0.01whichweredependedondosesandtheIC50was31.25µg/µLthegrowthcurveshowedthattheSGC-7901cellsofthecontrolgroupgrowedrapidlyfromtheseconddayafterbeingculturedfromthethirddaythenumberofthecellssurpassedthetreatedgroupsP0.05butthegrowthofcellsofthetreat-edgroupswhichwereinhibitedtodifferentdegreefromthefirstdaywiththeincreaseofdoseandtimetheinhibitionwasmoreeffec-tive.ConclusionPolysaccrhaidesfromsporesofAgaricusbaizeihadinhibitoryeffectsontheproliferationofgastricadnocacinomaSGC-7901cellswhichmaybetheantigastricancermechanismofpolysaccrhaidesfromsporesofAgaricusbaizeiMurill.KeywordspolysaccharidesofAgaricusbaizeifromhyphaeanasporesSGC-7901cellproliferation23320053CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEVol.23No.3Mar.2005480