地氯雷他定片的研究概述

河南城建学院生物工程系毕业论文毕业论文题目：地氯雷他定片的研究概述系别：生物工程专业：生物工程姓名：李慧妹学号：091407105指导教师：张现青河南城建学院2011年05月20日河南城建学院生物工程系毕业论文目录摘要............................................................ⅰABSTRACT..........................................................ⅱ前言............................................................1第一章地氯雷他定的概述............................................21.1地氯雷他定简介..............................................................................................21.2地氯雷他定的作用..........................................................................................21.2.1药理学作用............................................................................................21.2.2毒理学作用.............................................................................................31.3地氯雷他定的药代动力学...............................................................................41.4地氯雷他定的药物相互作用..........................................................................41.5使用地氯雷他定的注意事项..........................................................................5第二章地氯雷他定溶出度的检验......................................62.1检验方法..........................................................................................................62.1.1标准曲线的制备....................................................................................62.1.2含量测定.................................................................................................62.1.3含量均匀度.............................................................................................62.1.4溶出度测定............................................................................................62.2分析..................................................................................................................7第三章地氯雷他定在治疗慢性荨麻疹的应用............................83.1敏迪简介..........................................................................................................83.2西替利嗪简介..................................................................................................83.3.氯雷他定简介.................................................................................................93.4氯雷他定药代动力学......................................................................................93.5地氯雷他定与二代组胺药的比较...................................................................93.5.1地氯雷他定与敏迪的疗效结果比较.....................................................93.5.2地氯雷他定与西替利嗪的比较...........................................................103.5.3地氯雷他定与氯雷他定的比较...........................................................103.6结果................................................................................................................11第四章地氯雷他定片的展望.........................................12参考文献.......................................................15河南城建学院生物工程系毕业论文致谢...........................................................17河南城建学院生物工程系毕业论文i摘要地氯雷他定为非镇静性的长效三环类抗组胺药，是氯雷他定的活性代谢物，可通过选择性地拮抗外周H1受体，缓解过敏性鼻炎或慢性特发性荨麻疹的相关症状，具有强效、选择性的拮抗外周H1受体的作用，可治疗多种过敏性慢性疾病，主要有过敏性鼻炎、慢性荨麻疹、复发性血管性水肿、异位性皮炎和慢性湿疹。本文主要对地氯雷他定的研究状况和使用进行了论述，如药理学作用、毒理学作用和药代动力学，以及对其含量，含量均匀度和溶出度的检验方法。溶出度检验主要是对药品质量的控制和评价生产工艺的有效手段，反映药物在生物体内的吸收情况。本文简单论述了敏迪、西替利嗪和氯雷他定的药理学作用，它们都属于抗组胺类药物，可选择性地拮抗外周H1受体，但在药代动力学方面与地氯雷他定存在一定差异。在治疗慢性荨麻疹方面，将地氯雷他定与敏迪、西替利嗪和氯雷他定等进行比较，结果显示：地氯雷他定的疗效均高于第二代抗组胺药，不良反应均为一过性，这使得患者服用该药物后在很大程度上减少了生活困扰，比如服用后不出现头晕现象，有少例轻度嗜睡患者，未出现严重嗜睡情况。根据目前研究，由于第二代抗组胺药具有心脏毒性作用，第三代抗组胺药逐渐打入市场，给第二代抗组胺药造成很大的压力，使第二代抗组胺药销售量和销售金额有下滑趋势，地氯雷他定虽问世较晚，但因其毒理学，药效均优于第二代抗组胺药，在今后市场具有广阔的发展空间。关键词：地氯雷他定抗组胺药慢性荨麻疹活性代谢物河南城建学院生物工程系毕业论文iiABSTRACTAsnon-sedativeLong-actingtricyclicantihistamine,desloratadineistheactivemetaboliteofloratadine.WiththefunctionofbeingeffectivelyandselectivelyantagonistictoperipheralH1receptor,itisabletoreliefrelevantsymptomsofallergicrhinitisorchronicidiopathicurticariathroughselectivelyantagonizingperipheralH1receptor,thusitcantreatavarietyofchronicallergicdiseases,includingmainlyallergicmainlyallergicrhinitis,chronicurticaria,recurrentangioedema,atopicskinandchroniceczema.Thispapermainlydiscussesthepreviousresearchesandtheuseofloratadine,suchasitspharmacologicaleffect,toxicologicaleffectsandpharmacokineticsandthetestmethodforitscontents,contentuniformityanddissolution.Dissolutiontestingisameansmainlytocontroldrugquality,evaluateproductionprocessesandfigureouttheabsorptionofthereactiondrug.ThepaperbrieflydiscussesthepharmacologicalactionofMitel,cetirizineandloratadinewhichbelongtoantihistamines.TheyallhavethefunctionofselectivelyantagonizingperipheralH1receptor,butatthesametimetheyhavecertaindifferencesinpharmacokinetics.ComparedesloratadinewithMitel,cetirizineandloratadine,etc,intheconcernoftreatingchronicurticaria,theresultsshowthattheefficacyofdesloratadineishigherthansecond-generationantihistamines,andtheadversereactionsofdesloratadinearetransient,whichenablepatienttoreducetheproblemsinlifetoalargeextendaftertakingdesloratadine,forexample,patientwillnothavedizzinessandpatientwithmildsleepinesswillnothaveseriousdrowsinessaftertakingdesloratadine.Accordingtothecurrentresearch,asthesecond-generation