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(,100083),,,,,,,,,,[1,2],;;;;N949TheApplicationofBiomed2InformaticsinCardiovascularResearchDataandKnowledgeZHANGQi2Peng,SUNDong2Yong,LUMing,QINPu,SHANGTong(PekingUniversityInstituteofCar2diovascularScience,Beijing100083)AbstractWiththedevelopmentofbiotechnology,especiallytheprojectswhichleadtohighthroughoutexperimentalresults,lotsofdatahavebeenjammedineveryrelatedfields,andbrokethebalancebe2tweendataandknowledgeinthesefields.Itisurgenttorefinethesedata,andletthembemoreproduc2tive.Toavoidthesedatabeingdecayingintorubbish,technologyandtheorysuchasdatabase,statistics,datamining,knowledgemanagement,andartificialintelligencehadbeenappliedintobiologicandmedi2calstudyfields.So,anewstandaloneresearchsubject2biomed2infomaticshasbeenformed.Thispaperreviewedtheapplicationofbiomed2informaticsincardiovascularresearch,andgavetheviewforthefu2turedevelopmentofthissubject.KeywordsBiomed2informatics;Database;Datamining;Knowledgemanagement;Cardiovascularsci2ence,,,()1()([3]):(generaldatabases)(specialdatabase),,,:,,,,,:GenBank[4]Swis2sprot[5]PubMed[6];,,,,,,9112005362,:HPRD[7]Car2dio[8]BioPD[9],,,,,:CaGE[10]Heart22DPage[11],,,,1GeneBank://://://://archive.uwcm.ac.uk/search/mg/allgenesEGAD://hiv2web.lanl.govBDGP://://biobases.ibch.poznan.pl/ncRNARNAACTIVITY://mbcr.bcm.tmc.edu/smallRNARNAEuropeanSmallSubunitrRNADatabase://://pir.georgetown.eduPRINTS://://://://://hiv2web.lanl.gov/immunology/HIV,2,,,,02120053622HEART22DPAGE://angiodb.snu.ac.kr/ATM://://cardiogenomics.med.harvard.edu/homeCardiologyDatabase://cardio.bjmu.edu.cnCVCGD://cmbi.bjmu.edu.cn/CVDHM/,,,,,,,,,,,,,,,,,,,,,,,:(1):;(2):,;(3):,F,L,C,,CF,F;(4):,,,,,,;(5),,()(decisiontree),,,(SQL),,1212005362,,,,,,[12],[13](),,,(),[14,15](),,:;,,,(),:K2Means[16,17],,,,,,,,,,,,,,,,,,,,,,,,(HumanGeneNomenclatureDatabase,HGND)[18](GeneOntology,GO)[19],HGND,,,GO,,,:(1)ICPMICPM(InternationalClassificationofProceduresinMedi2cine)1976WHO,WHO(drugs);(2)MeSHNLMMeSH(MedicalSubjectHead2ings)MeSHUMLS;(3)UMLS(UnifiedMedicalLanguageSys2tem)NLM,1986,,;(4)GALEN,,,,GOUMLSGalen,(Stand2ardOperatingProcedures,SOPs),2212005362,,()(),,,,:(ObjectOrient)(Ontolo2gy)(JohnsHopkinsUniversity)(Humanproteinreferencedatabase),,,:;()(Ontology),(3)3/AmiGO(OBO)obo.sourceforge.net/list.shtmlDigitalAnatomistdepts.washington.edu/ventures/pfolio/fma.htmGalen(GO)Consortium(GXD)(UMLS)()(Car2dio),,,-----(:GeneOntol2ogy,UMLS)(Plug2in),,,,,,,,,,,3212005362:(1),,;(2),,;(3),;(4),,;(5),,,,,,,(,)1Conceptofbioinformatics.:TheAppli2cationsofBioinformaticsinCancerDetectionWorkshop.AnnNYAcadSci,2004,1020:19.3,,..:,2003.4BensonDA,Karsch2MizrachiI,LipmanDJ,etal.Gen2Bank.NucleicAcidsRes,2002,1:1720.5BoeckmannB,BairochA,ApweilerR,etal.TheSwiss2ProtproteinknowledgebaseanditssupplementTremblin2003.NucleicAcidsRes,2003,1:6570.6MacleodMR.PubMed::746752.7PeriS,NavarroJD,AmanchyR,etal.Developmentofhu2manproteinreferencedatabaseasaninitialplatformforap2proachingsystemsbiologyinhumans.GenomeRes,2003,13:23632371.8ZhangQP,LuM,ShiL,etal.Cardio:aweb2basedknowl2edgeresourceofgenesandproteinsrelatedtocardiovasculardisease.IinJCardiol,2004,97:245254.9ShiL,ZhangQ,RuiW,etal.BioPD:aweb2basedinfor2mationcenterforbioactivepeptides.RegulPept,2004,120:13.10BoberM,WieheK,YungC,etal.CaGE:cardiacgeneexpressionknowledgebase.Bioinformatics,2002,18:1