750种在研抗肿瘤药(最新)

2008CancerMEDICINESINDEVELOPMENTFORReportPRESENTEDBYAMERICA’SPHARMACEUTICALRESEARCHCOMPANIESFewthingscausepatientsmorefearanduncertaintythanacancerdiagnosis.Buttoday—becauseofasteadystreamofnewandimprovedmedicinesandtreatments—cancerincreasinglycanbemanagedandevenbeaten.Patientsandtheirfamiliesarelookingformoreandbettertreatments,andAmerica’spharma-ceuticalresearchcompaniesareresponding.Pharmaceuticalresearchersarenowworkingon750medicinesforcancer.Manyarehigh-techweaponstofightthedisease,whilesomeinvolveinnovativeresearchonusingexistingmedicinesinnewways.Themedicinesindevelopment—allineitherclinicaltrialsorunderFoodandDrugAdministrationreview—include110forlungcancer,theleadingcauseofcancerdeathintheUnitedStates;90forbreastcancer,whichisexpectedtostrikemorethan180,000Americanwomenthisyear;64forcolorectalcancer,thethirdmostcommoncancerinbothmenandwomeninthiscountry;and88forprostatecancer,whichthisyearisexpectedtokillmorethan28,000Americanmen.Additionalmedicinestargetbraincancer,kidneycancer,ovariancancer,pancreaticcancer,skincancer,andothers.Inaddition,companiesareworkingonmedicinestoimprovethequalityoflifeforcancerpatients.Thiscommitmenttopatientsandresearchisatthecoreoftheremarkableprogressmadeinthepastdecadefightingcancerthathasledtodeclinesinbothcancercasesandcancerdeaths.Deathratesforeightofthetop10cancersremainedlevelordeclinedduringthe1990s,accordingtoaJournaloftheNationalCancerInstitutereport.America’spharmaceuticalresearchcompaniesareworkingonmanynewcuttingedgeapproachestofightcancer.Theyinclude:•Amedicinethatinhibitsproductionofaproteinthatmayinterferewiththeeffectivenessofchemotherapy.•Adrugthatdeliversasyntheticversionofasubstancederivedfromscorpionsdirectlytobraintumorcells.•Amedicinedesignedtoinduceapowerfulimmuneresponsetomelanoma.•Apotentialfirst-linetreatment(meaningit’sgiventopatientsbeforeanyothertreatment)andfirst-in-classmedicinedesignedtotargetspecificcancercellsandkillthem,thenactivatethepatient’sgeneralimmunesystemtodestroycancer.•Onetherapyindevelopmentusesnewnanotech-nologythatenhancesthedeliveryofmedicinetothepatient,overcomingobstaclesinexistingtreatments.Despiteprogress,cancerremainsthesecondleadingcauseofdeathbydiseaseintheUnitedStates,exceededonlybyheartdisease.Thisyear,some565,650Americansareexpectedtodieofcancer—morethan1,500peopleaday.Thehundredsofnewmedicinestotreatcancernowbeingdevelopedbythepharmaceuticalresearchindustrydemonstrateourcommitmenttomeetingpatientneedsaswellasourbesthopeforstemmingthetollofcancer-relateddeaths.BillyTauzinPresidentandCEOPhRMA750MedicinesandVaccinesinDevelopmentOfferHopeintheFightAgainstCancerMEDICINESINDEVELOPMENTFORCANCER**Somemedicinesarelistedinmorethanonecategory.UnspecifiedCancersOtherCancersCancer-RelatedConditionsStomachCancerSolidTumorsSkinCancerSarcomaProstateCancerPancreaticCancerOvarianCancerMultipleMyelomaLymphomaLungCancerLiverCancerLeukemiaKidneyCancerHead/NeckCancerColorectalCancerCervicalCancerBreastCancerBrainCancerBladderCancer176090166428391222411086444749882364204144651772MEDICINESINDEVELOPMENTFORCancer2008MedicinesinDevelopmentforCancerBLADDERCANCERProductNameSponsorIndicationDevelopmentStatus*Advexin®IntrogenTherapeutics(seealsobrain,breast,head/neck,PhaseIcontusugeneAustin,TXlung,ovarian,prostate,other)[phone]ladenovecbelinostatCuraGen(seealsocolorectal,leukemia,lung,PhaseII(PDX101)Branford,CTlymphoma,ovarian,solidtumors)[phone]CDX-1307AVANTImmunotherapeutics(seealsobreast,colorectal,PhaseINeedham,MApancreatic)[phone]Celebrex®Pfizer(seealsocervical,colorectal,PhaseIIIcelecoxibNewYork,NYlung,prostate,skin,other)[phone]CG0070CellGenesysPhaseISouthSanFrancisco,CA(650)266-3000Chemophase™HalozymeTherapeuticssuperficialbladdercancerPhaseI/IIhyaluronidaseSanDiego,CA(858)794-8889EOquin®SpectrumPharmaceuticalsPhaseIIIapaziquoneIrvine,CA(949)788-6700Hexvix®PhotoCurebladdercancer(diagnosticimaging)applicationsubmittedhexylOslo,Norway®AstraZeneca(seealsobrain,solidtumors)PhaseIIgefitinibWilmington,DE(800)236-9933larotaxelsanofi-aventis(seealsobreast,pancreatic)PhaseIII(XRP9881)Bridgewater,NJ(800)633-1810Levulan®PDDUSAPharmaceuticalsdetectionofbladdercancerPhaseI/IIaminolevulinicWilmington,MA(seealsocolorectal,lung,[phone]acidstomach)MCC/HABionicheLifeSciencesPhaseIIIBelleville,ON(800)265-5464OGX-427IsisPharmaceuticals(seealsobreast,lung,ovarian,PhaseICarlsbad,CAprostate)[phone]OncogenexTechnologies(604)736-3678Vancouver,BCSCH58500Schering-Plough(seealsohead/neck,liver,PhaseI(p53genetherapy)Kenilworth,NJlung,cancer-related)[phone]SCH721015Schering-PloughPhaseIKenilworth,NJ(908)298-4000Valstar®IndevusPharmaceuticalsapplicationsubmittedvalrubicinLexington,MA(781)861-8444VB4845ViventiaBiotech(seealsohead/neck)PhaseIIMississauga,ON(905)361-8686*Formoreinformationaboutaspecificmedicineinthisreport,pleasecallthetelephonenumberlisted.3MEDICINESINDEVELOPMENTFORCancer2008BRAINCANCERProductNameSponsorIndicationDevelopmentStatus131-I-TM-601TransMolecularrecurrenthigh