移植物抗宿主病

IFN-γIL-17ACD4+(LN)SynAlloCD4+(Spleen)SynAllo7d14d28dLNSpleenVehicleVPASkin(tongue)VehicleVPALiverVehicleVPALungVehicleVPASmallintestineVehicleVPAColonIFN-γIL-17ACD4+(LN)VehicleVPACD4+(Spleen)VehicleVPA7d14d28dLNSpleenLNSpleenCD4Foxp3SynVehicleVPA7d14d28dVPAinhibitedtheinvitrodifferentiationofTh17CD4IL-17A00.2mM0.5mM1.0mM2.0mMAnnexinV7-AAD00.2mM0.5mM1.0mM2.0mMTheeffectofVPAontheviabilityofinvitrodifferentiatedTh17****CD4IFN-y00.5mM1.0mM1.5mMVPAinhibitedtheinvitrodifferentiationofTh1AnnexinV7-AAD00.5mM1.0mM1.5mMTheeffectofVPAontheviabilityofinvitrodifferentiatedTh1****VPAinhibitedthesecretionofIFN-yandIL-17AinCD4+TcellsAnnexinV7-AAD00.2mM0.5mM1.0mMTheeffectofVPAontheviabilityofCD4+Tcellp=0.1196VPA(mM)00.20.51.0p-AktThr308Actinp-AktSer473Aktp-Foxo1Foxo1p-GSK3βGSK3βVPA(mM)00.20.51.0Actinp-PDK1PDK1PTENPP2AbPP2AcPP1SAHA0.5uMVPA0.5mM0IP:AktAc-AktAkt00.51.0VPA(mM)p-AktThr308Actinp-AktSer473Aktp-Foxo1Foxo1p-GSK3βGSK3βVPA-+