三种新型化疗药物在难治复发白血病治疗中的应用

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20056143JournalofLeukemia6L7m89oma:June2005:;ol14:=o30(?)60@AB0C,20D?,。,。。1(Eo8oEeFan,GHG)11GHGIJ=K、,。GHGL,M,J=K!N,,J=KO,P1Q。J=K。GHG,KR。KGHG。GHGS,GHG。GHGKR,15Tmin1U1,1V41W5。,GHGP2Q。GHG,30DX40D,。GHG40D,(maY),,。,。GHG(ZGJ)225m[\m214m[]m2。GHG60D,。,。12GHG。1^^3_anEar‘ianTP3QGHG2a,1a(KZL)b,aT’(,,。、。,。’()))))*?a33aTTT*KTTTT*100^#^^21(2005)03$01B6%03*200433TT,1aLoFaEelliTc:TdeFFaTZ:THeeeionTK:TeETalTZ7elof7e8laeEiFTe7nfromeegTE9eT8efiaEriFT8oinETofThieiPJQTjaemaEolo[iFa:T1^^5:TB0k3lgT26B&2a^1BZanfelT_:TJrorTm:THoonTK:TeETalTKT8raFEiFal:TFom8re9eneiheTFlaeeifiFaEionTforT8efiaEriFTm7elof7e8laeEiFTe7nfromeegTE9eTTe7eEemPJQTHefiaErTjemaEolTnnFol:T2002:T24k5lgT343’3521^jaeleTj:T=ieme7erT:T9eeeelleTJ:TeETalTKT8efiaEriFTa88roaF9TEoTE9eTojnTFlaeeifiFaEionTofTm7elof7e8laeEiFTanfTm7elo8roliferaEiheTfieeaeeePJQTLeukemia:T2003:T1ak2lgT2aa(2B220?7EEin[TZTpTHefiaEriFTm7elof7e8laeEiFTe7nqfromeePJQTurrTjemaEolT?e8:T2004:T3k3lgT1a3)1aa21rEeenemaTJ:TGefferiTKTG9eTm7elof7e8laeEiFTe7nfromekelgTaT8ere8eFEiheTanfTrehieiT9i[9qli[9Ein[TFurrenETFonErohereieePJQTLeukT?ee:T2003:T2ak2lgT^5*12022ZJrTstuvwxyz{|}PJQT~€‚ƒ„…2004,2a(3)*1^3+1^^23ZufEi†HaE9o‡iolo[7:FlaeeifiFaEion:anffiqa[noeieofm7elof7e8laeEiFe7nfromePJQReeEHraFE?eelinjaemaEol:2004:1ak4lg543,55a24d9aoo:ˆuL:ouo:eEalG9em7elof7eq8laeEiFe7nfromeeganal7eieof8ro[noeEiFfaFqEoreanfFom8arieonof8ro[noeEiFe7eEemein12B9ineee8aEienEefromaein[leineEiEuEionPJQjemaEol:2002:3k3lg13a-14425jaelej:Raumann‰:Rer[eEraeeerpG9e‰nqEernaEionalHro[noeEiFrForin[r7eEemk‰HrrlforF9ilf9oofm7elof7e8laeEiFe7nfromekZJrlanf‘uhenilem7elomonoF7EiFleukemiakJZZLlPJQLeukemia:2004:1Bk12lg200B.201426;er‡ur[9p:KF9Een?:ZaeeR:eEalKfqfiEional8ro[noeEiFhalueof‡onemarroi9ieqEolo[7in8aEienEeeu‡FlaeeifiefaFForfin[EoE9einEernaEional8ro[noeEiFeForin[e7eEemform7elof7e8laeEiFe7nfromeePJQJournalofliniFalnnFolo[7:2003:21k2lg2a3/2B22aRairfH:rimmoneHpY8reeeionofE9eoilmeŠEumor[enekoG1linnormal9emaEo8oieeiePJQpY8jemaEol:1^^a:25g31203202B;anJ:JeroenH:_no8e†:eEalK‡normaloG1eY8reeeioninE9eJq34ne[aEiheFomq8arEmenEinm7elof7e8laeEiF‡onemarroiPJQRriEie9JournalofjaemaEolo[7:2002:11Bk4lg102a110332^RaferH:=ieme7er:oe‡er†:eEaloG1[eneeY8reeeiongueefulmarkerforminimalreeifualfieeaeeinF9ilf9oofm7elof7e8laeEiFe7nfromeeanf‘uhenilem7elo2monoF7EiFleukemiaPJQpuro8eanJournalofjaemaEoloq[7:2004:a3k1lg2532B30illoniJ:†oEEarfip:Zeeeac:eEalri[nifiqFanEForrelaEion‡eEieenE9efe[reeofoG1eY8reeeionanfE9einEernaEional8ro[noeEiFeForin[e7eEemeForein8aEienEeiiE9m7elof7e8laeEiFe7nfromeePJQlinnnFol:2003:21k10lg1^BB41^^531rie[lohad:dilohFohar:ermakJ:eEalJ7qnamiFeofEelomereeroeionanfiEeaeeoFiaEioniiE9[enomeineEa‡iliE7inm7elof7e8laeEiFe7nfromeekZJrlanfaFuEem7elo[enoueleukemiaariein[fromZJrgamarkeroffieqeaee8ro[noeiePJQLeukemia?eeearF9:2004:2Bk10lg10135102132?i[olin†:HorEaZ:Ru[liK:eEalcloiF7EoqmeEriFfeEeFEionofaFFeleraEefEelomeree9orEenin[inm7elof7e8laeEiFe7nfromeegForrelaEioneiiE9aeEiolo[iFalanfFliniFal6‡iqolo[iFalfinfin[ePJQpuro8eanJournalofjaemaEolo[7:2004:a3k5lg351735B*(1^a6+),,。(*200481191^)*2005:01;30)(**)1B620056143JournalofLeukemia6L7m89oma:June2005:;ol14:=o3(LL),3?@AL!BCD。ECE35mFGm2H1ImFJm2(5K),3L4。ECE(@M;)10mFNm2(5OK)。(PLE),。3(@Q),2(CQ),1RS。T,LL,@ALBC。BeranU4VECE(APW)22#(@AAL)25。ECE2mFXm2Y5K,@M;,3Z4。@Q2IS,APW2[S(6\22),@AAL2IS([]25)。123IS。ECEAPW@AAL。ECE,。Qo^in_k7U5V1[33ECE,0[‘2[OmFam2b5OK,1@AL$BC@Q,1ALCQ,。ECE,。WeicerU6VE53,:ECE25d[[5OmFem2f5OK,30Omin;(ra%@)1OFgm2h5OK,2O9。@Q:AL10OS(4i3R),LL50OS(3j6),@AL&BC12OS(1kI)。l。,W。,,ECE。(@Em)nECE,ECE@EmP=,。@orce_U[V@Em、ra’@、ECE@E52AL,10@Q(1ROo),。,ECEp,,q,r。,s。,UIV。LeoniURVtLE,(tlu)ura(@vECE,20AL,1@Q60OS。10,10@Q。,。tlu。2OOO(tluKarawin,tlu)21OOOtlutlu,,2t)ara*;,2t+ara,EC。,P=。tluP=P=,,P=,。,tluQ=x,。22OOOtlunKer_on(@LL)。@LL,,,,tlu。,tlu@LL。tlu,@LL。Wy9iazoneU10Vtlu@Em32@LL(15,1[)。tlu30OmF{m2|3OK;@EmO300OmF}m2~3K。14(44OS)@Q,16(50OS)CQ,2(6OS)。@QO,R€15(60OS);51[(2ROS)。24,20O(62OS),14(44OS)。tlu@Em@LL,@Q。Bo_y9U11V60@LLt@AUtlu‚@Emƒ(AME)V,3[tluO25OmF„m2,1…3;@EmO200OmF†m2,1‡3ˆOAMEO6OmF‰m2,1。23t@A@EmO600OmFŠm2,1;AMEOIOmF‹m2,1。30(50OS)@Q,1[(2IOS)CQ。1R。t@A。tlu。tlura-@,(Œ.@Wt)tLŒ。U12VtLŒ@Q50OSR0OS。tLŒ。QuwiaU13VtLŒ/(MP),32AL13APW。24(53OS)@Q,5(11OS)CQ。40OS12。tLŒ0MPAL。tLŒ1AME,AMEO10OmFŽm2,51AL,@Q5ROS,CQ11OS。tluAL,E_imweriKouU14Vtlu、ra2@@P33A7locarF(@_),At@,32AL。11(34OS)@Q,121ROS。14(44OS)34,6(1IOS),3(;‘P)。A7locarF。3OOO(2’32’,2’4,KtK@)31OOOKtK@KtK@(KtK@PC)(KtK@EC)。KtK@PC,P=,K@EC1I[20056143JournalofLeukemia6L7m89oma:June2005:;ol14:=o3。?@AB(@AB)C=D,C=DC=D,C=D、?@,。。?@?@,,,。,?@Dra!@20E15F。?@AB。?@、、,?G(2HeoI7#2J:2J$ifluorouKine)L0M,。3220L0,NruneOalPE16F?@Q00mRSm2,@T;15min,?@43QmmolUL;400mRVm226WmRXm2,?@L4mmolYL56mmolZL。,?@15[20mmol\L19,?@AB。?@400mR]m2?@AB,。?@(^9ePmaIimumP^olera^ePo_e,‘AC)4PQ00PmRam2(@T;4Q0Pmin)。?@。‘N(‘TAb?@)34,26Q@‘L%cB‘Cd。63Pe。E1WF。‘N。ca__E1QFAT(?@P10PmRfm2,@T;P12P9,WP200PmRgm2;(irino^ehan)40PmRim2j3P),11,1QPk。limmieriE1LF?@?lu,D‘L1Q,2Qn。,。,oolpE20FA;ANq。ABA、、(^9io^e8a)、

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