中医药计算系统生物学与寒热证候研究

WorldScienceandTechnology/ModernizationofTraditionalChineseMedicineandMateriaMedica***(100084):2006212212:2007201209*291(2006BAI08B05):,:;(200366):,:;(2004BA721A47):,:**:,,,,:,;Tel:[phone],E2mail:[e-mail]:,,,,,,:,,,,,,,,,21,,,[1],(ComputationalSystemsBiology),,[2],,,,[3],,,501©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:,:??,,(),1.,,,,,,,,,,,,,,,,,,,,,,,,,,2.,,,,,,,,,,,:(1),,,,(2),,,,,;,3.,,,,[4]601©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:,?(RA),85RA,5;MedlineRA,5,RA,,,[5],,?(SARS,),SARS,,(SaO2),[6];,(Hp)[7];,,,Meta[8][9],,?,10:,[10],,1999,[11],,,,,,,2.30--(NEI),,,?NEI,NEI,NEINEI,,,,,701©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.()38(),OMIMNEI,(Pathway),,,,,,,,,,,[12],,,,,,3.,,,,,,,,[13];,,--(HPA)[14],(,),,,,,,,,(KaiA,KaiB,KaiC)[15],,4.,,NEI,,,17,HPA[16],NEINEI,NEI,NEI-dbNEI[17]dbNEICSNDBKEGGUniGeneOMIMPubMed,NEIdbNEINEI;,,,[17],NEI,,5.,,801©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[18],NEI[19],(Angiogenesis)[18],LMMA(VEGFEGFTNFIL6)(LOO-CV),LMMA,,,Pathway,,,LMMA[18],,,,(1),,1.1,,,,(1),,,,,,,,,,,[20],,,,,,,MMP3/TIMP-1,[21],,,,[22],[23],,,901©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:???,,,,[12],,[12],,,,,[23],,,,,,,,,:,,,,,,,,,,,,,,,,,,:,1HiesingerPR,HassanBA.Geneticsintheageofsystemsbiology.Cell,2005,123(7)11731174.2VenturaBD,LemerleC,MichalodimitrakisL,SerranoL.Frominvivotoinsilicobiologyandback.Nature,2006,443527533.3HoodL,HeathJR,PhelpsME,LinB.Systemsbiologyandnewtech2nologiesenablepredictiveandpreventativemedicine.Science,2004,306640643.4BarabasiAL,OltvaiZN.Networkbiology:Understandingthecellsfunctionalorganization.NatureReviewsGenetics,2004,5(2)101113.5,,..,2006,26(11)988991.6LiS,WangR,ZhangY,etal.SymptomcombinationsassociatedwithoutcomeandtherapeuticeffectsinacohortofcaseswithSARS.AmJChinMed,2006,34(6)937947.7LiS,LuAP,ZhangL,etal.Anti-Helicobacterpyloriimmunoglobu2linG(IgG)andIgAantibodyresponsesandthevalueofclinicalpres2entationsindiagnosisofH.pyloriinfectioninpatientswithprecancer2011©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(3)14.10,..,2006,2014.11..21-.:.1999442.12LiS,ZhangZ,WuL,etal.UnderstandingZHENGintraditionalChi2nesemedicineinthecontextofneuro-endocrine-immunenetwork.IETSystemsBiology,2007,(1)5160.13,,..,2003,15(7)922924,930.14LiS,LuAP,LiB,etal.Circadianrhythmsonhypothalamic-pituitary-adrenalaxishormonesandcytokinesofcollageninducedarthritisinrats.JournalofAutoimmunity,2004,22(4)277285.15LiS,FangYH.ModelingcircadianrhythmsofproteinKaiA,KaiBandKaiCinteractionsincyanobacteria.BiologicalRhythmResearch,2007,38(1)4353.16.-HPAT.,2004,24(9)841843.17ZhuangY,LiS,LiY.dbNEI:aspecificdatabaseforneuro-endo2crine-immuneinteractions.NeuroendocrinologyLetters,2006,27(1/2)5359.18LiS,WuLJ,ZhangZQ.Constructingspecificbiologicalnetworksthroughcombinedliteratureminingandmicroarrayanalysis:aLMMAapproach,Bioinformatics,2006,22(7)21432150.19WuLJ,LiS.CombinedLiteratureMiningandGeneExpressionAnaly2sisforModelingNeuro-Endocrine-ImmuneInteractions.LectNotesComputSc2005,36453140.20ButcherEC.Cancellsystemsbiologyrescuedrugdiscovery?NatureReviewsDrugDiscovery,2005,4(6)461467.21LiS,LuAP,WangYY,etal.SuppressiveeffectsofaChineseherbalmedicineQing-Luo-Yinextractontheangiogenesisofcollagenin2ducedarthritisinrats.AmJChinMed,2003,31(5)713720.22FanTP,YehJC,LeungKW,etal.Angiogenesis:fromplantstobloodvessels.TrendsinPharmacologicalSciences,2006,27(6)297309.23,,,..,2002,14(11)14291431,1442.ComputationalSystemsBiology-basedTCMResearch:aCaseStudyofCold/HotZHENGandAssociatedFormulaShaoLi(TsinghuaUniversity,100084Beijing)OnlythroughtheviewofthesystemcanoneunderstandthecharacteristicsoftraditionalChinesemedicine(TCM),anancientmedicalsystem.Usingtheapproachofcomputationalsystembiology(CSB),authorhascreatedamethod,namedTCMCSB,tounderstandthemethodologiesusedbyTCM.Asanovelresearchmethod,TCMCSBisdesignedtoshiftthestrategyofsubstance-functiontotheonefocusingonrelation-function,creatinganewpathfrominformationintegrationtosystemsmodeling.FollowingtheroadmapofInteractionNetworkFuncti