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3.2,;EC,,,Klocker,NIF,BDNFN-tert-butyl-(2-sulfophenyl)-nitrone(S-PBN)RGCs3.3CaspasesCaspases,p53(IAP)Bcl-2(caspaseIDEVD-fmkcaspaseIVAD-fmk)Caspases,Caspase(-1-3-8-9),,Caspase-9CNTF()3.4DNA,,Bcl-2,Martinou[7]Bcl-2,RGCs50%,Bcl-2InoueTBcl-2,,1CuiA,LuQ,SoKF,etal.CNTF,notothertrophicfactors,promotesaxonalregenerationofaxotomizedretinalganglioncellsinadulthamsters.InvestOphthalmolVisSci,1999,40(3):760-766.2BlancoRE,Lopez-RocaA,SotoJ,etal.Basicfibroblastgrowthfactorappliedtotheopticnerveafterinjuryincreaseslongtermcellsurvivalinthefrogretina.JCompNeurol,2000,423(4):646-658.3NegishiH,DezawaM,OshitariT,etal.OpticnerveregenerationwithinartificialSchwanncellgraftintheadultrat.BrainResBull,2001,55(3):409-419.4,,.GAP-43mRNA.,2005,5(5):902-905.5KlockerN,CellerinoA,BahrM.Freeradicialscavengingandinhibitionofnitricoxidesynthasepotentiatestheneurotrophiceffectsofbrairrderivedneurotrophicfactoronaxotomizedretinalganglioncellsinvivo.JNeurosci,1998,18(3):1038-1046.6KoeberlePD,BallAK.Neurturinenhancesthesurvivalofaxotomizedretinalganglioncellsinvivo:combinedeffectswithglialcellline-de-rivedneurotrophicfactorandbrain-derivedneurotrophicfactor.Neuroscience,2002,110(3):555-567.7MartinouJC,Dubois-DauphinM,StapleJK,etal.OverexpressionofBCL-2intransgenicmiceprotectsneuronsfromnaturallyoccurringcelldeathanexperimentalischermia.Neuron,1994,13(4):1017-1030.(:),,,,,,,;;;R28271A1609-6614(2007)06-0503-03:730070,,CaulophyllumrobustumMaxim.,,305ChineseJournalofPracticalMedicine200776[1]1[1]1.1,,,1.2,,2,2.1:(Magnoflorine)(Taspine)N-(N-methylcytisine)[3],0.45%[2][4],0.34%0.42%,0.39%0.48%2.2ABCDE,ACDE(Hederagenin)[2][6]C,7.46%33.13.1.1[7]:,;,;,,3.1.2[8];3.2[5]-,(HMQ-4),HMQ-44HMQ-42,,;,HMQ-44,[9]H2O2,MTTHMQ-4,HMQ-4H202ECVNONOS,NF-KB,ECVNO,NOS,3.3[10],[11,12],MTTELISA,,,:3.0mg/ml1.5mg/ml,TGF-1EGF;,,4,,,,,,,405ChineseJournalofPracticalMedicine200776,,,1..:,1989,419.2..:,1979,112.3LUCPieters,TessDebruyne,MagdaClaeys,etal.IsolationofadihydrobenzofuranLignanfromsouthAmericandragon’sblood(CrotonSPP.)asaninhibnitorofcellproliferation.JNatProd,1993,56(6):899.4,,,..,2006,26(12):1706.5,,..,2003,38(1):14.6,,..,2005,33(5):14.7,..,1997,17(1):8.8,,,..,1997,17(2):8.9,,..,2003,38(1):14.10PerdueGP,BlomsterRN,BlakeDA,etal.SouthAmercianplants:taspineisolationandanti-inflammatoryactivity.JPharmSci,l979,68(1):124.11,,..,2005,28(7):579.12,,,..,2005,9(3):386.(:),,,,,,DNAP-;;R285A1609-6614(2007)06-0505-05AbstractGarlicisbothawideuseasseasoningandanantiquityasmedicine.Itcontainsmanykindsoforganosufidecompounds(OSCs)includingwater-solubleandoil-soluble.ScientistshavediscoveredthatantimutagenesisandanticarcinogenesiseffectsofOSCsfromgarlicconstituentsreceivedconsiderableattention.OSCscanleadtocellcyclearrest,inductionofapoptosis,inhibitionofDNAadductformationandfree-radicalscavenging,modulationofP-glycoprotein-mediatedmultidrugresistance.Keywordsgarlic;organosuifidecompounds;anticarcinogenicaction(garlic),(AlliumSativumL.)[1]2080,,(OSCs),,:243000,[4,6]1,33,17,(14g/100g),(5090g/100g),(0.020.03g/100g),(2.83.9g/100g),(100120g/100g),(4377g/100g),(0.30.5mg/505ChineseJournalofPracticalMedicine200776